March 6, 2024 News by Margarida Maia, PhD ACTRIMS 2024: Tolebrutinib fails to eliminate iron rim lesions in Phase 2 trial Nearly one year of treatment with tolebrutinib, an oral small molecule being developed by Sanofi, failed to eliminate iron rim lesions in adults with multiple sclerosis (MS), according to data from a small Phase 2 clinical trial. Researchers are continuing to examine study results to determine…
February 26, 2024 News by Marisa Wexler, MS Dark rim on MS lesions seen with standard MRI may mark activity An imaging feature called the T1-dark rim, which is visible on standard MRI scans of people with multiple sclerosis (MS), could help to identify paramagnetic rim lesions (PRLs), a study suggests. PRLs are regions of chronic active inflammation that cause ongoing nerve damage. They’re associated with disease activity and…
May 16, 2023 by Lori Lebson Guest Voice: My journey from MS caregiving to healthcare science Guest columnist Lori Lebson completed her PhD in neuroimmunology at the University of South Florida. After completing her doctorate, she continued her education as a National Multiple Sclerosis Society Neuroimmunology Postdoctoral Fellow at Johns Hopkins. Lebson has more than 10 years of pharmaceutical experience and serves as the head of…
July 18, 2022 News by Marisa Wexler, MS Certain MS Lesions Linked to Worse Disability, but Location Not a Factor The presence ofĀ iron rim lesions (IRLs), which are regions of chronic nervous system damage with ongoing inflammation, visible on MRI scans, is linked with more substantial disability in people with multiple sclerosis (MS),Ā according to a new study. However, the connection between these lesions and worse disability does not…
June 25, 2021 News by Somi Igbene, PhD Raised Serum NfL Levels May Indicate Chronic Active Lesions Raised serum neurofilament light chain (sNfL) levels may indicate the presence of brain lesions with chronically active inflammation that are linked with more aggressive forms of multiple sclerosis (MS), a new study suggests. People with high sNfL levels, the study revealed, had greater numbers of chronic inflammation lesions and…
December 12, 2019 Columns by Tamara Sellman Need to Know: MS and Smoldering Lesions Editor’s note: “Need to Knowā is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum. This week’s question is inspired by two forum topics about silent inflammation from August 2019. Have an experience you want…
August 16, 2019 News by Ana Pena PhD Dark Rimmed Brain Lesions May Be Signal of Aggressive Disease, NIH Study Says Brain lesions appearing as dark rimmed, “smoldering” spots on imaging scans, representing active inflammation, may be a hallmark of more aggressive and disabling forms of multiple sclerosis (MS), researchers at theĀ National Institutes of Health (NIH) report. Using a powerful MRI brain scanner and a 3D printer, the…