Losing the sense of smell is associated with a higher likelihood of worse disease outcomes for people with multiple sclerosis (MS), according to a six-year follow-up study. Specifically, patients who are getting worse at identifying and discriminating odors are at higher risk of disability worsening, relapse-independent MS progression, and…
symptoms
Experiencing certain stressors during childhood may predict the future presence and severity of fatigue, pain, and psychiatric conditions associated with multiple sclerosis (MS), according to a new U.S. study. Childhood physical and emotional stressors were each significantly linked to a higher likelihood of MS patients experiencing each of the…
Welcome to “MS News Notes,” a column where I comment on multiple sclerosis (MS) news stories that caught my eye last week. This week, the stories cover research presented at the joint meeting of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and the…
In a surprise discovery, researchers found that deleting a protein called integrin alpha-3 blocked harmful immune cells from accessing the brain — and prevented the onset of symptoms — in a mouse model of multiple sclerosis (MS). Now, the researchers say that targeting this protein might be one way…
Nabiximols, the cannabis-based oral spray sold as Sativex, is available for reimbursement as an add-on therapy for moderate to severe spasticity in adults with multiple sclerosis (MS) in Ireland who failed to respond as intended to other spasticity medications. Marked by muscle stiffness and involuntary spasms or twitches,…
Brain atrophy (shrinkage) in people with multiple sclerosis (MS) begins on average more than five years before disease symptoms appear, according to a new study based on machine learning models. “Although the onset of progressive brain tissue loss measured by MRI is not synonymous with the true biological…
Six months of treatment with foralumab, administered into the nose, led to decreases in microglial activity in five of six people with nonactive secondary progressive multiple sclerosis (SPMS) involved in an expanded access program. Microglia are resident immune cells in the brain believed to play a role in driving…
I try not to let my life revolve around multiple sclerosis (MS), but there’s no escaping the fact that the disease affects every part of it. That’s a bit of a conundrum and often frustrates me to no end. If there’s a bright side to be found, it’s that…
New research by scientists in Austria may shed light on the link between the Epstein-Barr virus (EBV) and multiple sclerosis (MS), and explain why only some people infected with EBV — previously found to raise the risk of MS by 32 times — go on to develop the neurodegenerative disorder. Distinct…
Multiple sclerosis (MS) patients had significantly more sickness-related work absences in the years leading up to their disease onset than people in the general population, a recent Swedish analysis showed. Scientists believe the findings support the growing notion that there is an MS prodrome, during which early signs of…
Blood levels of neurofilament light chain (NfL), a marker of nerve damage, were seen to increase about a year or two prior to disability worsening in people with multiple sclerosis (MS), particularly among patients whose disease progressed without any relapse activity. That’s according to new data presented at the…
Use of high-efficacy therapies can lower the risk of disability progression in people with childhood-onset multiple sclerosis (MS), particularly if given in early disease stages when disabling symptoms are negligible. That’s according to data shared at the 9th joint meeting of the European Committee for Treatment and…
With my kids in school, me being retired, and, of course, the limitations of my multiple sclerosis (MS), I have a lot of free time on my hands. I’d like to say that I always use it productively, but that’s far from the truth. I putter — if you…
Infection with the Epstein-Barr virus (EBV) may prime the immune system to accidentally attack a brain protein called ANO2, new research shows. The findings may explain how EBV infection can lead to developing multiple sclerosis (MS), at least in some patients. Daniel Jons, PhD, a scientist at the…
Welcome to “MS News Notes,” a column where I comment on multiple sclerosis (MS) news stories that caught my eye last week. Here’s a look at what’s been happening: ‘Silent’ MS progression Readers of the MS News Today website and Facebook page sometimes wonder why their MS…
People with multiple sclerosis (MS) who develop progressive multifocal leukoencephalopathy (PML) as a side effect of Tysabri (natalizumab) often see their neurological symptoms worsen severely during the infection and their disability gradually accumulate over time. That’s according to a study in Austria, which also showed that most disability progression…
Anxiety, depression, and other mental health issues are nearly twice as common in people with multiple sclerosis (MS) in the five years preceding disease onset than they are in the general public, a study reports. These findings add to growing evidence that people with MS often go through a…
The original title for this week’s column wasn’t so much of a headline, but more of an essay. I had to shorten it. I’d also better write a bit more here so that my opening paragraph is a tad longer. Ah, being all meta about it has saved my vegan…
Most disability worsening events happen independent of relapse activity across all types of multiple sclerosis (MS), including clinically isolated syndrome (CIS) and early relapsing-remitting MS (RRMS), a new study reports. The findings challenge the idea that relapses are the main driver of disability worsening in early relapsing…
Assessing a person’s daily walking patterns using the Google Maps Timeline tool may help doctors remotely monitor fatigue, walking ability, and disease severity in people with multiple sclerosis (MS), a study suggests. The digital tool is built in the smartphone application Google Maps and records daily walking distance and…
Back in spring, I wrote about the fatigue that accompanies multiple sclerosis (MS) and how difficult it was to describe and for others to understand. That’s true, of course, but really, the entirety of MS is difficult to explain. Factor in the variety of symptoms and the…
Problems with sexual dysfunction are a concern for multiple sclerosis (MS) patients of all ages, but the issues tend to have distinct causes as people age, a new study highlights. The study, “Age-Related Differences in the Severity of Sexual Dysfunction Symptoms and Psychological Distress in Individuals with…
The expression of a viral protein known as W-Env leads to the inflammatory activation of brain cells and impairs myelin repair in mouse models of multiple sclerosis (MS), a study reports. “Our study shows that the presence of W-Env in the brains of MS patients appears to generate a…
I ask a lot of questions. I have to, because I’ve come to realize that I don’t actually know that much. Asking questions (even to myself) is the only solution. Oddly enough, though, learning new things doesn’t completely scratch my itch, as the answers just keep showing me how much…
People with multiple sclerosis (MS) under treatment with Ocrevus (ocrelizumab) commonly experience fluctuations in the severity of their symptoms — but these changes aren’t related to the timing of Ocrevus infusions, a study reports. Although many patients on Ocrevus report a ‘wearing off’ effect between infusions, findings suggest…
Certain COVID-19 vaccines do not appear to worsen the symptoms of multiple sclerosis (MS), and may provide protection for at least six months after a booster dose, according to a study in Spain. The study specifically examined mRNA vaccines, or those that use a piece of RNA to teach…
Researchers have identified nearly two dozen genes that help to control the movement of immune cells into the brain and spinal cord during multiple sclerosis (MS). Findings may form the basis for the further development of MS treatments that aim to reduce disease activity by blocking the infiltration…
Big breath, for my travails below necessitate a catch-up on my story so far. For once, my multiple sclerosis and the myriad joyous comorbidities it’s conferred on me — trigeminal neuralgia, lymphedema, diplopia, spasticity — have given me a break. So have the fellow travelers who’ve…
A question that’s been bothering me lately is this: It seems that more than a few neurologists have a less than optimal understanding of multiple sclerosis (MS). Why is that? In my four decades of living with MS, and during the several years I’ve written this column…
Using disease-modifying therapies (DMTs) doesn’t reduce fatigue levels in people with multiple sclerosis (MS), a study in Norway suggests. Anxiety and depression were both associated with fatigue, suggesting “there are other underlying causes of fatigue than focal inflammation, on which DMTs have an effect,” the study’s researchers wrote…