February 18, 2022 News by Steve Bryson, PhD ‘Cellular Big Bang’ Reveals Immune Driver in Study of Twins An increased production of CD25 ā an immune receptor that regulates T-cell proliferation and activation ā is the most noticeable blood cell immune alteration in people with multiple sclerosis (MS) compared with their unaffected identical twins, a study discovered. The increased CD25 levels, which correlated with disease severity, were…
January 18, 2021 News by Marta Figueiredo, PhD Tonix Files for Patent for TNX-1500 to Treat Autoimmune Diseases Tonix Pharmaceuticals has filed a patent application with the World Intellectual Property Organization covering the use of TNX-1500 ā its third-generation anti-CD154 antibody ā for the prevention and treatment of autoimmune diseases, such asĀ multiple sclerosisĀ (MS), and organ transplant rejection. āThere remains a significant need for new treatments with improved…
October 27, 2020 News by Marta Figueiredo, PhD Metabolic Enzyme PKM2 a Potential Therapeutic Target for MS, Preclinical Study Suggests SuppressingĀ pyruvate kinase M2 (PKM2) ā an enzyme involved in cellular metabolismĀ ā in T-helper (Th) immune cells lessenedĀ myelin loss and disease severity in a mouse model of multiple sclerosisĀ (MS). Myelin,Ā the protective sheath around nerve fibers that helps speed transmission of signals between nerve cells, isĀ damaged and lost…
August 31, 2020 News by Steve Bryson, PhD Immune T-cells Trigger Early MS Inflammation, Twin Study RevealsĀ A comparison of immune cells isolated from identical twins ā in which only one of each pair was diagnosed with multiple sclerosis (MS) ā identified a population of immune-regulating T-cells present in those with asymptomatic brain inflammation, a study has found.Ā …
October 8, 2019 News by Patricia Inacio, PhD Targeting Toxic T Helper Cells – Those with CXCR6 Receptor – Seen to Prevent MS in Mouse Model Targeting the chemokine receptor CXCR6, a protein at the surface of a certain group of T helper cells, preventedĀ the development of multiple sclerosis (MS) in a mouse model of the disease, a study reports. Its findings suggest that antibodies targeting T helper cells ā known drivers of MS ā…
June 15, 2016 News by Patricia Inacio, PhD ‘Master Switch’ for Autoimmune Diseases Like MS Potentially Seen in DNA of Immune Cells Regions of DNA calledĀ super-enhancersĀ regulate immune cell activity, including the body’s response to threats like inflammation or pathogens, and now scientists have found that they also harborĀ genetic variantsĀ associated with autoimmune diseases ā gene variants that may be the “master switches” for these conditions. The findings were described in the study ā…
December 1, 2014 News by Patricia Inacio, PhD New Insights Into “T Helper Cells” Could Guide Future Multiple Sclerosis Therapies A recent study entitled āSTAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammationā describes a new subset of T helper immune cells ā TH-GM ā thatĀ express a particular cytokine profile with implications inĀ therapeutics for multiple sclerosis. The study was…