Lemtrada Might Outperform Ocrevus in Preventing MS Relapses, Italian Researchers Say

Patricia Silva, PhD avatar

by Patricia Silva, PhD |

Share this article:

Share article via email
Lemtrada Ocrevus

Lemtrada (alemtuzumab) may be more effective in preventing relapses in multiple sclerosis patients than the newly approved Ocrevus (ocrelizumab), according to a study presented April 28Ā atĀ the American Academy of Neurology (AAN) 2017 Annual MeetingĀ in Boston.

TheĀ study, supported by Sanofi Genzyme and Bayer HealthCare Pharmaceuticals, compared the two drugs using an analysis ofĀ how many patients are neededĀ to treat to prevent one additional bad outcome.Ā This type of analysis, called ā€œnumber needed to treat” (NNT), allows comparisons of drugs in the absence of trials that compareĀ different drugs side by side.

Although Lemtrada is more efficient, researchers from Italy’s Vita-Salute San Raffaele University concluded, only real-life dataĀ couldĀ confirm their findings.Ā The study is based on severalĀ previous clinical trials, including patients treated for two years with 12 mg of Lemtrada in the Phase 2 CAMMS223 trial (NCT00050778), Phase 3 CARE-MS I (NCT00530348), and Phase 3 CARE-MS II (NCT00548405). Those in the second CARE-MS study were 628 patients who had not responded to an earlier treatment.

Researchers extracted Ocrevus data from the two OPERA trials (NCT01247324 and NCT01412333), with a total of 835 patients in the analysis.

The groups differed in how long they had been ill and how disabled they were. Expanded Disability Status Scale (EDSS) scores were somewhat lower among Lemtrada patients. The duration of disease was also longer in the Ocrevus-treated groups ā€” 6.7 years compared to 1.9 years in CAMMS223 and CARE-MS I and 4.5 years in CARE-MS II.

Both Lemtrada and Ocrevus had been compared to interferon-beta 1a in the trials, and researchers used information of how the drugs differed in absolute risk for relapses and disability to interferon to computeĀ NNT. In fact, they found NNT to be lower in Lemtrada patients than among those treated with Ocrevus.

For relapses, NNT wasĀ 5 in the combined CAMMS223 and CARE-MS I trials, 4 in the CARE-MS II study, and 8 in both OPERA studies. In addition, NNTĀ to prevent disability progression waslower with Lemtrada.Ā This indicates that Lemtrada more effectively prevented relapses and disability progression than Ocrevus, but researchers stressedĀ that real-life experience is needed to confirm the findings.