Editor’s note: To learn more about the link between the Epstein-Barr virus and MS, read Ed’s May 2020 column titled “More Evidence Links Epstein-Barr Virus to MS.”
Now, the National Institutes of Health (NIH) are reporting another possible connection. Researchers at the Center for Autoimmune Genomics and Etiology at Cincinnati Children’s Hospital Medical Center have found a viral protein in EBV-infected cells. They think that the protein may turn on a “switch” that activates genes that are associated with an increased risk of autoimmune diseases. MS, of course, is an autoimmune disease.
Most people are infected with EBV. According to the Centers for Disease Control, it’s one of the most common human viruses. It usually appears in early childhood and its symptoms are generally very mild or don’t appear at all. But the EBV infection remains with people.
Scientists know that the EBV infection can produce a protein called EBNA2. In this new research, they found that EBNA2 activates some of the human genes associated with the risk of lupus and several other autoimmune diseases, including multiple sclerosis. Simply put, it flips that autoimmune disease “switch.”
“These findings suggest that EBV infection in cells can actually drive the activation of these genes and contribute to an individual’s risk of developing the disease,” said lead researcher John B. Harley, MD, PhD, in an NIH news release.
And that means more hope for new MS treatments and maybe even a cure.
Daniel Rotrosen, MD, director of the Division of Allergy, Immunology, and Transplantation at the National Institute of Allergy and Infectious Diseases, added that “now that we understand how EBV infection may contribute to autoimmune diseases in some people, researchers may be able to develop therapies that interrupt or reverse this process.”
Wouldn’t that be nice?
The journal Nature Genetics published the detailed research findings.
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Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Multiple Sclerosis News Today or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to multiple sclerosis.
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