Marisa Wexler, MS,  senior science writer—

People with multiple sclerosis (MS) who responded to cognitive rehabilitation showed healthier connections between certain brain regions on functional MRI scans than did MS patients who did not respond to the rehab program, a new study reports. These results indicate that certain brain regions need to be working…

In its inaugural issue, a publication from The Gerontological Society of America provides information about recognizing and managing pseudobulbar affect — uncontrolled outbursts of crying or laughing that the authors say are one of the most “underrecognized and undertreated” symptoms of multiple sclerosis (MS) and other neurological conditions. The…

Men with multiple sclerosis (MS) show differences in health-related behaviors based on how much they value certain masculine ideals, according to a new study that suggests possible negative effects of masculinity in terms of seeking medical care. Results from the study — which specifically focused on white males in…

People with multiple sclerosis (MS) who are on therapies that deplete antibody-producing B-cells can mount an effective T-cell immune response to COVID-19 vaccination, a new study shows. The findings suggest that the vaccines strongly activate other parts of the immune system that are helpful in fighting the virus,…

Transcutaneous tibial nerve stimulation (TTNS), a procedure sending an electric current through the skin to nerves in the legs, is generally safe and feasible in people with overactive bladder due to multiple sclerosis (MS), according to a proof-of-concept study. Though the study was not designed to test the efficacy…

People with multiple sclerosis (MS) are absent from their places of employment nearly twice as often as individuals without the neurodegenerative disease, according to a new study based on U.S. data. The results also showed missing work is significantly more common for MS patients who are unmarried, experience…

By engaging a variety of stakeholders from across the multiple sclerosis (MS) community, researchers in the U.S. Deep South were able to enroll more than 800 patients to a clinical trial in just over two years in what’s considered the largest study of an exercise intervention in MS patients…

A team of researchers has created a three-dimensional (3D) map of the lymphatic vessels that drain the brain, and demonstrated that these vessels are organized similarly in mice and in humans. The researchers propose measuring these vessels using MRI scans could “allow longitudinal imaging of disease progression that may be…

Variations in more than a dozen genes on the sex-determining X chromosome are more common among those with multiple sclerosis (MS) than in the general population, according to an analysis of nearly 500,000 people in the U.K. Many of these genes are known to play roles in biological processes…

Autologous hematopoietic stem cell transplant (aHSCT), a procedure that aims to “reset” the immune system, generally reduces disability and relapse rates in people with multiple sclerosis (MS), according to a new meta-analysis. “Current data encourage a broader application of AHSCT for treating patients with MS while still considering…

Two years of treatment with Ocrevus (ocrelizumab) outperformed Rebif (interferon beta-1a) at preventing myelin loss in people with relapsing multiple sclerosis (MS), according to a new analysis of data from the OPERA II clinical trial. Ocrevus’ protection against demyelination was observed both in MS lesions,…

An international team of scientists is calling for more rigorous studies to test whether exercise can help protect the nervous system from damage in people with multiple sclerosis (MS). The scientists argue clinical trials that have evaluated exercise in MS have marked flaws in their design, making…

Providing electrical stimulation to the vagus nerve, a large nerve that plays important roles in modulating nonconscious bodily processes like digestion and heart rate, can improve motor learning in mice, a new study shows. The approach specifically helped the animals learn motor tasks faster and achieve better performance levels in…

A number of genetic variations related to vitamin D metabolism were not significantly associated with the severity of multiple sclerosis (MS), according to a recent study. The study, “Role of Multiple Vitamin D-Related Polymorphisms in Multiple Sclerosis Severity: Preliminary Findings,” was published in Genes. In MS, the body’s immune…

A new machine learning strategy was able to differentiate tremor specific to multiple sclerosis (MS) from tremor related to other diseases, with more than 90% accuracy, according to a new study. “The proposed method, with high classification accuracy and strong correlations of [tremor] features to clinical outcomes, has clearly…

Most available studies suggest a connection between childhood trauma and multiple sclerosis (MS), from earlier symptom onset to potentially poorer outcomes, but more research is needed to understand this association, a review paper highlights. While several high-quality studies have been published, the scientists noted “considerable heterogeneity [variability] in methodology, including inconsistencies…

Digoxin, an approved medication for certain heart conditions, promoted the repair of myelin — the protective sheath around nerve fibers that is progressively lost in multiple sclerosis — in mouse models of the disease, a study reports. Combining digoxin with an experimental immune-modulating therapy was more effective at promoting myelin…

A man-made molecule derived from a naturally occurring amino acid was able to promote the repair of the myelin sheath — a fatty coating around nerve fibers that is damaged in multiple sclerosis — in a mouse model of the disease, a new study reports. “These findings suggest that ……

Note: This story was updated on July 25, 2022, for the headline to reflect researchers gave this information in a perspective paper, not a study.  Bans on abortion and other reproductive care limitations are likely to have a profound impact on the care of people with multiple sclerosis (MS)…

The European Medicines Agency (EMA) has agreed to review a request to approve Polpharma Biologics‘ biosimilar natalizumab for the treatment of multiple sclerosis (MS). This marks the first time the regulatory agency accepted a marketing authorization application for a biosimilar of Tysabri, an approved MS treatment. “The acceptance…

The presence of iron rim lesions (IRLs), which are regions of chronic nervous system damage with ongoing inflammation, visible on MRI scans, is linked with more substantial disability in people with multiple sclerosis (MS), according to a new study. However, the connection between these lesions and worse disability does not…

Multiple sclerosis (MS) patients treated with rituximab were more than five times less likely to experience a relapse compared with patients given Tecfidera (dimethyl fumarate), according to data from a Phase 3 clinical trial. Patients on the experimental therapy also were 32% more likely to have no evidence…

An independent committee of experts has recommended that the Phase 2 portion of the EMBOLD clinical trial continue as planned without a sample size adjustment, following an analysis of safety and effectiveness data. The trial is testing Atara Biotherapeutics‘ experimental medication ATA188 in progressive forms of multiple…

Rates of sexual and emotional abuse are higher in women with multiple sclerosis (MS) compared with women in the general population, according to a new study from Norway. These women are also at more than two times higher risk of being revictimized, which occurs when a person who has…

Treatment with Aubagio (teriflunomide) may significantly reduce the risk of relapse in children with multiple sclerosis (MS), according to a new analysis of the TERIKIDS clinical trial that took into account data from adult trials. Results were in the paper “Reinterpreting Clinical Trials in Children With…

Some prodromal symptoms of multiple sclerosis (MS) — symptoms that are evident before the disease begins in earnest — could help to predict the course of MS, a new study proposes. In particular, its researchers suggest that MS patients with prodromal depression are more likely to be diagnosed…

Levels of certain inflammatory proteins in the cerebrospinal fluid, the liquid around the brain and spinal cord, may help predict the risk of relapse activity for individuals with early multiple sclerosis (MS), a new study found. High levels of three such proteins were predictive of a greater risk of…

An MRI technique called quantitative susceptibility mapping (QSM) can be used to accurately identify remyelinated brain lesions in people with multiple sclerosis (MS), a research team has discovered. Remyelinated lesions are those in which the myelin sheath — the protective coating around nerve fibers that is progressively lost…

The safety and efficacy of the approved multiple sclerosis (MS) therapy Mavenclad (cladribine) in a real-world group of patients were similar to what had been demonstrated in clinical trials, a new study reports. Among 243 people with relapsing-remitting multiple sclerosis (RRMS), more than 60% showed no…

Long-term treatment with Zeposia (ozanimod) stabilizes or even improves cognitive function in adults with relapsing forms of multiple sclerosis (MS), particularly among those with greater brain volumes. That’s according to five years of data from the completed SUNBEAM Phase 3 clinical trial (NCT02294058) and the ongoing…