News

Switching to Ocrevus or Kesimpta doesn’t alter either’s effectiveness

Switching between CD20-targeting antibodies Ocrevus (ocrelizumab) and Kesimpta (ofatumumab) doesn’t affect either’s effectiveness at lowering disease activity and slowing disability progression in people with multiple sclerosis (MS), a real-world study in Germany shows. Researchers did see a link between switching and a faster, continuous decrease of immunoglobulin…

Sex-related gap found for use of DMTs in MS patients ages 18-40

Despite evidence supporting the safety of disease-modifying therapies (DMTs) during pregnancy, women with multiple sclerosis (MS) in their childbearing years are significantly less likely than men in the same age range to receive these typically most effective treatments, according to a study from France. The researchers found what they…

Fatigue, cognition in MS patients aren’t barriers to healthy habits

Three self-reported prevalent symptoms among people with multiple sclerosis (MS) – fatigue, mobility issues, and cognitive impairment – are generally not associated with lower engagement in healthy lifestyle factors, a study in Australia shows. However, in the long term, mobility difficulties may significantly reduce adherence to physical activity, a…

Stem cell transplant may slow RRMS disease progression: Study

Autologous hematopoietic stem cell transplant (aHSCT) could slow disease progression in people with relapsing-remitting multiple sclerosis (RRMS), according to a study tracking MS patients in Sweden. The procedure was associated with sustained reductions in biomarkers linked to progressive MS. The results also showed that a significant portion of patients…

DMTs before, during MS pregnancy generally safe: Registry data

About 62% of multiple sclerosis (MS) patients use disease-modifying therapies (DMTs) before and during pregnancy, and the medications don’t appear to harm their health or their babies’ health, recently reported data from an international registry show. Most pregnancies resulted in live, full-term births, and these births generally occurred…

Fumarate-based MS therapies have equal benefit for different races

Fumarate-based therapies like Tecfidera (dimethyl fumarate) and Vumerity (diroximel fumarate) are equally effective among Black, Hispanic, Asian, and white adults with relapsing forms of multiple sclerosis (MS) in the U.S., the largest real-world study of its kind shows. “The findings of this study suggest that fumarate medicines…

Fenebrutinib curbs brain lesions in MS, Phase 2 study finds

Fenebrutinib significantly reduced the occurrence of new brain lesions with active inflammation in people with relapsing multiple sclerosis (MS), a Phase 2 clinical trial found. In the open-label extension portion of the FENopta trial (NCT05119569), disease activity “remained very low” for nearly one year, researchers wrote, with 98%…

Cold sore virus may play role in MS, mouse study finds

A common virus that causes cold sores, herpes simplex virus type 1 (HSV-1), may contribute to multiple sclerosis (MS). That’s according to a study by researchers at the University of Illinois Chicago (UIC). In mice lacking a protein that helps control HSV-1, infection led to the degradation of the…

PAG-MS-guided exercise offers path to easing MS depression

Regular exercise that follows established guidelines for physical activity in multiple sclerosis (MS) leads to clinically meaningful gains in depression and supports its use as a nonpharmacological treatment for people with MS, a meta-analysis of 12 studies suggests. The meta-analysis, “Effects of meeting exercise guidelines on depression and…

Music therapy for MS may help with motivation, heat sensitivity

A six-week music therapy intervention significantly reduced psychosocial fatigue — or fatigue that interferes with a person’s motivation and ability to engage in social and daily activities — and heat sensitivity in people with multiple sclerosis (MS), according to data from a clinical trial. Participants who received music therapy…

Mesenchymal stem cell therapy shows potential: Study review

Mesenchymal stem cell (MSC) therapy is safe and well tolerated, and leads to improvements in disability and a reduction in lesion burden in people with multiple sclerosis (MS), according to a review of published studies. MSC treatments also reduced levels of biomarkers associated with nerve damage and inflammation,…