December 12, 2016 News by Patricia Silva, PhD Discovery of Calcium Channel Crucial to Myelin Formation May Provide New MS-treatment Leads A specific type of channel that facilitates calcium flow is needed for normal development of cells that produce a shield, called myelin, around nerve fibers ā a finding that could open up new approaches to regenerating the myelin-producing cells (called oligodendrocytes) lost in multiple sclerosis (MS). Researchers now hope to…
December 12, 2016 News by Wendy Henderson Walking Aids for Multiple Sclerosis Patients This video from Dulci Hill addresses the topic of walking aids. Many multiple sclerosis patients may feel unstable or fatigued when walking and using a cane, wheeled walker or mobility scooter may help to provide stability, aid balance and help you to get around and keep your independence.
December 12, 2016 News by Patricia Inacio, PhD 3-D Structure of CCR2 Receptor, While Bound to Its Inhibitors, Captured for 1st Time Scientists unraveled the 3-D structure of a key receptor linked to inflammation in multiple sclerosis (MS) ā the CC chemokine receptor 2 (CCR2) receptor ā when it is bound to two inhibitor molecules simultaneously. This potentially important finding, which allowsĀ scientists to see how these molecules fit together, couldĀ aid inĀ developingĀ betterĀ therapeutics that…
December 9, 2016 News by Patricia Silva, PhD Key Myelin Protein, MBP, Seen to Break Down Differently in Brains of MS Patients ResearchersĀ monitoring the decomposition of an abundant brain protein, called myelin basic protein (MBP), discovered that this protein breaks down differently in people withĀ multiple sclerosis (MS) than it does in those without the disease, particularly in two surface regions, and that difference may be the trigger for immune reactions and myelin…
December 9, 2016 News by Malika Ammam, PhD Study Confirms Link Between Mutations in IL-23A Gene and MS Risk A new study confirmed the involvement of three genetic variants, or mutations, of theĀ interleukin-23A (IL-23A) gene, and one variant of its receptor IL-23R, Ā in the risk of developing multiple sclerosis (MS) and other related inflammatory nervous disorders, together known as inflammatory demyelinating diseases (IDD). Details of this study, āCharacterization of…
December 8, 2016 News by Alice MelĆ£o, MSc Imbalances in Brain Microbiota May Be Behind Demyelination in MS, Study Says Alterations in microorganisms in the brains of multiple sclerosis (MS) patients could contribute to underlying disease mechanisms, including demyelination, according to researchers. The study, āBrain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis,ā was published in the journalĀ Scientific Reports. It is widely recognized that the…
December 8, 2016 News by Joana Fernandes, PhD MS Patients in Clinical Trial of GNbAC1 May Continue with Therapy in Extension Study Multiple sclerosis (MS) patients now taking part in a Phase 2b clinical trial testingĀ the efficacy and safety of theĀ antibody GNbAC1Ā will be invited to continue withĀ treatment for two more years under a planned extension study, the biopharmaceutical companiesĀ GeNeuroĀ andĀ ServierĀ recently announced. Several MS therapies rely on the capacity of antibodies to…
December 7, 2016 News by Patricia Inacio, PhD Lower Oxygen in Brain’s Gray Matter Linked to More Impairment in Mouse Study The less oxygen that a mouse withĀ multiple sclerosis (MS) has in the gray matter of itsĀ brain, the more mental and physical deterioration it isĀ likely to have, a new study suggests. The study confirms previous research indicating a connection between low oxygen levels in a mouse’s gray matter and the development…
December 7, 2016 News by Patricia Silva, PhD Copaxone Use During Pregnancy by RMS Patients Now Possible in EU European users ofĀ Copaxone (glatiramer acetate injection, Teva Pharmaceutical) to treatĀ relapsing forms of multiple sclerosis (RMS) will no longer see a warning that the drug should not be used during pregnancy. A report assessing this change in the drug’sĀ marketing authorization within the European Union ā a process known as…
December 6, 2016 News by Patricia Silva, PhD Consortium of Multiple Sclerosis Centers Calls for Abstracts for 2017 Annual Meeting The Consortium of Multiple Sclerosis Centers (CMSC) is inviting researchers and healthcare professionals to submit abstractsĀ to be presented at its 31st Annual Meeting, focusing onĀ developments inĀ multiple sclerosis (MS) research, patient care and treatment outcomes. The 2017 CMSC meeting, organized by the groupās Continuing Professional Education Committee, will take…
December 6, 2016 News by Patricia Silva, PhD Study Detailing New Way T-cells Attack Myelin May Explain Why Some MS Therapies Fail In a new and possibly important insight into the workings of the immune system, researchers discovered what it takes for T-cells to start targeting myelin sheets in multiple sclerosis (MS). The findings may also explain why some drugs fail to prevent autoimmunity in MS. The study, āTrans-presentation…
December 5, 2016 News by Joana Fernandes, PhD Low Vitamin D Levels at Birth May Influence MS Risk in Adults, Study Suggests The risk of developing multiple sclerosis (MS) later in life may be higher for babies born with low levels of vitamin D, according to a new study in the journal Neurology. The study, āNeonatal Vitamin D Status And Risk Of Multiple Sclerosis – A Population-Based Case-Control Study,ā was…
December 5, 2016 News by Patricia Silva, PhD Hormonal Pathway That Controls Blood Pressure Shows Anti-inflammatory Potential A hormonal system that controls blood pressure was also seenĀ to counter inflammatory processes in a mouse model of multiple sclerosis (MS) by influencing immune cells to take on a more anti-inflammatory profile. Researchers believe that it might be possible to manipulate the system with drugs, so as to boost anti-inflammatory…
December 2, 2016 News by Joana Fernandes, PhD Fat Bubbles and Ultrasound May Offer Way of Getting MS Therapies Directly to Brain A new ways ofĀ delivering drug therapies directly to the brain, overcoming the limitation imposed by the blood-brain barrier (a permeable barrier that protects the brain), has been discovered. The technique ā which makes use of lipid bubbles and ultrasound ā may pave the way for new treatments against neurological disorders,…
December 2, 2016 News by Patricia Inacio, PhD Lemtrada Lessens MS Disability in People Who Respond Poorly to Other Therapies, Study Says Data from the CARE-MS II clinical trialĀ showed that Lemtrada (alemtuzumab) canĀ lessen pre-existing disabilities in patients with relapsing-remitting multiple sclerosis (RRMS) who failed to respond adequately to previous disease-modifying therapies, according to a study of the trial’s data. The treatment was evaluated againstĀ Rebif (interferon beta-1a)Ā therapy. The study, āAlemtuzumab…
December 1, 2016 News by Patricia Silva, PhD ICER Releases Draft Report on Disease-modifying Therapies for MS, Welcomes Comment The Institute for Clinical and Economic Review (ICER) has released aĀ Draft Evidence ReportĀ evaluating the comparative clinical effectiveness and value of disease-modifying therapies (DMTs) for patients with relapsing-remitting and primary-progressive forms of multiple sclerosis (MS). Through Dec. 21, patients, the public, and other stakeholders can accessĀ the 82-page report and…
December 1, 2016 News by Patricia Silva, PhD Protein from Parasite Lowers Relapse Rates, Evidence of Demyelination in Mice with MS A moleculeĀ secreted by a parasite was seen to prevent autoimmune reactionsĀ in a mouse model of multiple sclerosis (MS). As this molecule, a protein factor or peptide, also worked to preventĀ diabetes, researchers suggestĀ it might be developed intoĀ aĀ potential treatment for autoimmune diseases. The study, “A parasite-derived 68-mer peptide ameliorates…
November 30, 2016 News by Joana Fernandes, PhD New Pool of Neural Stem Cells Found in Brain Meninges Could Lead to New Therapies for MS, Other Diseases Researchers have found neural stem cells (immature cells that can become neurons) in the meninges of the brain, a three-layer structure that protects the nervous system, according to results of a new study. The discovery of this pool of stem cells in the adult brain opens new possibilities for the…
November 30, 2016 News by Charles Moore Philips Unveils In-Progress Radiology Portal for Diagnosing, Treating Neurological Diseases Royal Philips recently announced the introduction of the IntelliSpace Portal 9.0, the latest edition of itsĀ advanced comprehensive visual analysis and quantification platform for neurological disorders. The platform was presentedĀ at the 2016 Radiological Society of North America Annual Meeting (RSNA), taking placeĀ through Dec. 2 in Chicago. Currently a work in…
November 29, 2016 News by Patricia Silva, PhD UV Light May Lead Way to New Treatment for MS and Inflammation Researchers have foundĀ a way to harness inflammation with the help of ultraviolet (UV) light, making it possible to design an anti-inflammatory treatment that is more specific and causes fewer side effects. If this approach canĀ be developed forĀ clinical treatment, itĀ likely will have a large impact on the lives of people with…
November 29, 2016 News by Joana Fernandes, PhD NIH Grant to Support Research into Role of Copper in Demyelination The National Institutes of Health (NIH) awarded a $45,000 grant to a team of investigators, led by Tia Walker, PhD, atĀ Indiana University Northwest, to supportĀ aĀ research project into the role of copper in multiple sclerosis (MS). The award is a first for IU Northwest, and will allow the team to…
November 28, 2016 News by Charles Moore Partnership Receives $1.2M from California Initiative to Advance Precision Medicine for MS Sutter Health, a not-for-profit healthcare network serving more than 100 northern California communities, has been awarded $1.2 million by theĀ California Initiative to Advance Precision MedicineĀ (CIAPM) to support patients living with multiple sclerosis (MS) and help improve how health matters are targeted and treated across the entire state.
November 28, 2016 News by Joana Fernandes, PhD Palliative Care Helps Improve Life Quality, Ease Pain of Anyone with Serious Illness Palliative care helps to ease the symptoms ofĀ serious illnesses, providing peopleĀ with cancer and thoseĀ withĀ otherĀ life-altering diseases, likeĀ multiple sclerosis (MS) or cystic fibrosis,Ā a better quality of life, according to a study published in the Journal of the American Medical Association (JAMA). In the study, āAssociation Between Palliative Care And Patient…
November 23, 2016 News by Alice MelĆ£o, MSc New Research into T-cells May Lead to Immune-based Therapies for MS, Other Diseases A recent study published in Nature CommunicationsĀ showed, for the first time, that a protein complex called LUBAC is responsible for controlling the late-stage development of immune T-cells before they are released into the bloodstream. Several types of cells compose the immune system, working together to fight infections or cancer.
November 22, 2016 News by Patricia Silva, PhD RSNA 2016: Philips to Debut Advanced Software Applications to Evaluate Neurological Disorders Royal PhilipsĀ willĀ introduce a new suite of magnetic resonance (MR)-based software applications at the upcomingĀ Radiological Society of North Americaās 102ndĀ Scientific Meeting and Annual Assembly (RSNA 2016;Ā #RSNA16) Nov. 27 to Dec. 2 in Chicago. Philipsā Ingenia family of digital MRI systemsĀ provides radiologists with a unique set…
November 22, 2016 News by Patricia Silva, PhD Australian Researcher Honored for Discovery That May Lead to Anti-Inflammatory Therapy Dr. Rebecca Coll, a young researcher at theĀ University of Queensland Institute of Molecular Bioscience, won theĀ 2016 Research Australia Discovery AwardĀ for her work in identifying promising anti-inflammatory compoundsĀ that are able to block the NLRP3 inflammasome ā a key driver of inflammation.Ā The discovery could greatly benefit patients with inflammatory diseases,…
November 21, 2016 News by Patricia Silva, PhD MS Foundation Launches New Website and Redesigns Focus Magazine The Multiple Sclerosis Foundation, whichĀ is celebrating its 30thĀ anniversary this year, has launched a new website to make access to information and services easier, and a newly designed MS Focus magazine. MS Focus magazine is the foundationās publication dedicated to common challenges, solutions, and stories of the…
November 21, 2016 News by Patricia Silva, PhD New Company Specializing in Stem Cell Platform for MS and Other Ills Raises $48.5M Magenta TherapeuticsĀ has completed itsĀ first round of financing, raisingĀ $48.5 million to develop ways of bringing bone marrow stem cell transplants to more patients with autoimmune diseases, such as multiple sclerosis (MS), among other illnesses. The new companyĀ aimsĀ to develop the first complete platform that can overcomeĀ the challenges in stem cell transplants,…
November 18, 2016 News by Patricia Silva, PhD Discovery MS Launches in North Carolina with Series of Research Efforts Discovery MS, a nonprofit research initiative based at the David H. Murdock Research Institute (DHMRI)Ā in North Carolina,Ā had its official launch recently, and announcedĀ a series of research projects intoĀ multiple sclerosis (MS). The initiative uses private funding to advance research aiming to develop new prognostic and diagnostic tools for MS.
November 18, 2016 News by Patricia Silva, PhD AXIM Biotech to Get U.S. Patent Covering All Cannabinoids in Its Chewing Gums AXIM BiotechnologiesĀ announced that theĀ United States Patent and Trademark Office (USPTO) will be issuing a patent coveringĀ all cannabinoids ā both natural and synthetic ā Ā used in a chewing gum delivery system that may be included in itsĀ cannabinoid-containing, controlled-release chewing gum products. The USPTO has given the company aĀ Notice of…