February 27, 2024 News by Margarida Maia, PhD Black MS patients in US score poorly on walking, physical ability tests Black people with multiple sclerosis (MS) scored lower on tests of walking and physical function than did white patients, regardless of social determinants of health such as education or income, a U.S. study reported. These findings add to a growing understanding of how MS manifests in Black people, and…
February 26, 2024 News by Marisa Wexler, MS Dark rim on MS lesions seen with standard MRI may mark activity An imaging feature called the T1-dark rim, which is visible on standard MRI scans of people with multiple sclerosis (MS), could help to identify paramagnetic rim lesions (PRLs), a study suggests. PRLs are regions of chronic active inflammation that cause ongoing nerve damage. They’re associated with disease activity and…
February 26, 2024 News by Andrea Lobo, PhD High incidence, prevalence of pediatric-onset MS in Sweden Sweden has a consistently high incidence and prevalence of pediatric-onset multiple sclerosis (PoMS), according to a recently published study. Incidence measures the number of new cases identified during a certain period, while prevalence measures the proportion of people in the population with the condition. Data show the disease is…
February 23, 2024 News by Margarida Maia, PhD Most MS patients stay relapse-free 6 years after stem cell transplant About 4 in 5 people with relapsing-remitting multiple sclerosis (RRMS) who receive a stem cell transplant remain free of relapses for at least six years, and this may translate into being able to get back to work, a small study from Norway suggests. The study, āAutologous hematopoietic…
February 23, 2024 News by Steve Bryson, PhD Magnetic brain stimulation aids motor function, balance in MS trial Coupling a noninvasive brain stimulation procedure with an intensive rehabilitation program significantly improved motor function and balance in adults with relapsing-remitting multiple sclerosis (RRMS), a randomized clinical trial finds. High-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment approach that delivers pulses of magnetic fields to modulate nerve…
February 22, 2024 News by Margarida Maia, PhD Complement protein activation is linked to more severe MS Complement proteins, especially when activated in the brain and spinal cord, may contribute to nerve cell damage and more severe multiple sclerosis (MS) symptoms, a study that offers insights into a possible therapeutic target suggests. The study, āComplement Activation Is Associated With Disease Severity in Multiple Sclerosis,ā was…
February 22, 2024 News by Marisa Wexler, MS Prioritize high-efficacy DMTs for children with MS, study suggests Children with multiple sclerosis (MS) who start on high-efficacy therapies experience fewer relapses and reduced MRI disease activity in the following years, compared with those who are treated first with moderate-efficacy therapies, according to a new study. Rates of severe side effects are similar for both groups, but the…
February 21, 2024 News by Margarida Maia, PhD Melatonin at night may help with morning balance, strength in MS Taking melatonin before bedtime may help balance and muscle strength in people living with multiple sclerosis (MS), according to a study from Tunisia. Those benefits are in addition toĀ making for more restful sleep. While the findings come from a small number of patients, they suggest melatonin supplements may…
February 21, 2024 News by Andrea Lobo, PhD Use of DMTs in pregnancy on big upswing recently: Study in France More women with multiple sclerosis (MS) got pregnant in recent years, probably linked to a significantly higher use of disease-modifying therapies (DMTs) during pregnancy, according to a nationwide study in France. DMTs are a type of treatment that can alter MS course, by reducing the risk of relapses,…
February 21, 2024 News by Marisa Wexler, MS Treatment of progressive MS hits milestones in recent years: Review Treatment options for progressive types of multiple sclerosis (MS) have expanded dramatically over the past decade, and several promising experimental therapies are in late stages of clinical development, a new review paper highlights. The study, “Clinical trials for progressive multiple sclerosis: progress, new lessons learned, and…
February 20, 2024 News by Lindsey Shapiro, PhD Chronic inflammatory lesions linked to more aggressive MS in US study The presence in the brain of chronic inflammatory lesions ā called paramagnetic rim lesions (PRLs) ā in people with multiple sclerosis (MS) is associated with a greater relapse burden and faster disability progression in the long term, according to a new U.S. study. Among more than 150 patients who…
February 20, 2024 News by Margarida Maia, PhD Nabiximols, cannabis-based spray, eases spasticity in real-world use Nabiximols, a cannabis-based oral spray sold as Sativex, was reported to considerably ease spasticity ā unusual muscle tightness or stiffness ā in about two-thirds of the multiple sclerosis (MS) patients using it for three months in a real-world study in Germany. For most patients, the treatment also…
February 19, 2024 News by Lindsey Shapiro, PhD Sanofi launches Phase 3 frexalimab trials after positive Phase 2 data Bolstered by Phase 2 trial data showing that frexalimab safely reduces the number of brain lesions in people with relapsing forms of multiple sclerosis (MS), developer Sanofi has launched a pair of Phase 3 studies that will test the investigational therapy in relapsing and progressive MS. One of…
February 19, 2024 News by Margarida Maia, PhD Caffeine tablets may help MS patients’ balance, mobility Taking caffeine tablets ā the equivalent to about two cups of coffee a day ā may help people with multiple sclerosis (MS) keep their balance and move more easily, which could aid their quality of life, a small study suggests. While the tablets may…
February 16, 2024 News by Marisa Wexler, MS Online therapy platform found to boost mental health of patients COMPASS, a digital tool that provides support for managing the daily challenges of living with a long-term health condition such as multiple sclerosis (MS), significantly reduces psychological distress and improves mental health in these patients, data from a randomized clinical trial show. The intervention consists of multiple online modules…
February 16, 2024 News by Lindsey Shapiro, PhD Larger trials needed to evaluate intermittent fasting for MS: Review An intermittent fasting (IF) diet may lead to immune and metabolic alterations that ease multiple sclerosis (MS) symptoms and improve quality of life, a recent review of published studies suggests. While evidence from these few small clinical trials indicates an IF diet…
February 15, 2024 News by Steve Bryson, PhD MS trial to test magnetic brain stimulation for overactive bladder A small clinical trial in Texas is testing whether a noninvasive magnetic brain stimulation procedure can ease the symptoms of overactive bladder in adults with multiple sclerosis (MS). The randomized Phase 2 study (NCT06072703) is ongoing at Houston Methodist Hospital, and is recruiting about 29 women with stable…
February 15, 2024 News by Andrea Lobo, PhD Sudo raises $30M more to advance TYK2 inhibitor therapies to trials Sudo Biosciences has secured an additional $30 million in funding to support the development of two TYK2 inhibitor therapies for multiple sclerosis (MS) and other neurological and skin conditions ā and now is aiming to launch clinical trials later this year. With a second close of its Series…
February 14, 2024 News by Marisa Wexler, MS Researchers call for more pragmatic clinical trials in MS Few multiple sclerosis (MS) clinical trials have used a so-called pragmatic design, which evaluates the effectiveness of interventions in real-life routine practice, a study has found. Because such trials are better able to emulate conditions in real-world clinical practice and provide solid and more actionable evidence to inform treatment…
February 14, 2024 News by Mary Chapman Aptar to operate, develop Biogen’s lifestyle support apps for MS Under a new agreement, Biogen is transferring ownership of certain digital health solutions ā including two existing mobile applications, or apps, offering lifestyle support to people with multiple sclerosis (MS) ā to Aptar Digital Health. The collaboration calls for Aptar, part of AptarGroup, to handle product design…
February 13, 2024 News by Lindsey Shapiro, PhD Nitric oxide metabolites in blood could aid diagnosis of MS: Study Measuring levels of nitric oxide metabolites in the blood could be a diagnostic biomarker for multiple sclerosis (MS), recent research suggests. The molecules, collectively called NOx, were elevated in the blood of people with relapsing-remitting MS (RRMS) and primary-progressive MS…
February 13, 2024 News by Marisa Wexler, MS Computational model captures multiple sclerosis, genes to organism An international team of scientists has created a computational model that seeks to give a picture of multiple sclerosis (MS) at multiple biological scales, from tiny molecules to whole cells to organs and its effects on the body overall. āIn this study we have…
February 12, 2024 News by Marisa Wexler, MS Immune cells in MS may enter brain via newly found ‘sewer system’ In neurological inflammatory conditions like multiple sclerosis (MS), inflammatory immune cells may enter the brain through arachnoid cuff exit (ACE) points ā newly discovered structures that normally seem to serve as a type of sewer system in the brain, helping to move out waste. Figuring out exactly how immune…
February 12, 2024 News by Andrea Lobo, PhD Sharp lymphocyte drop seen quickly in SPMS patients on Mayzent Some people with secondary progressive multiple sclerosis (SPMS) using Mayzent (siponimod) show a severe drop in their number of lymphocytes, a condition known as lymphopenia, shortly after starting treatment, a report on its real-world use in the U.K. found. Lymphocytes are white blood cells that help the immune…
February 9, 2024 News by Mary Chapman Helius to showcase PoNS device at physical therapy meeting Feb. 15-17 Helius Medical Technologies will be showcasing its now-accredited PoNS device ā designed to improve walking ability in people with multiple sclerosis (MS) ā at this year’s American Physical Therapy Association (APTA) Combined Sections Meeting (CMS), slated for Feb. 15-17. The annual meeting, which will feature educational sessions, exhibits,…
February 9, 2024 News by Margarida Maia, PhD Crocin supplement seen to reduce signs of inflammation in MS Taking a two-month supplement of crocin, an antioxidant found in the cooking spice saffron, helped to reduce signs of inflammation in people with multiple sclerosis (MS) who took part in a small study in Iran. However, crocin had no effect on symptoms of depression or anxiety compared with a…
February 8, 2024 News by Steve Bryson, PhD Non-invasive MEG scan can predict cognitive therapy outcomes in MS A non-invasive scan that measures network activity across the brain was able to predict the outcomes of behavioral therapies designed to improve cognitive function in people with multiple sclerosis (MS), a study demonstrates. Brain network function, as assessed by the test, called magnetoencephalography (MEG), “could play an important role…
February 8, 2024 News by Marisa Wexler, MS Non-opioid compound has potential to ease chronic nerve pain Scientists at The University of Texas at Austin (UT Austin) have developed a novel non-opioid compound, called FEM-1689, that is able to reduce pain related to nerve damage in animal models. Neuropathic pain, or pain caused by damage to nerves, is a common symptom of multiple sclerosis (MS)…
February 7, 2024 News by Margarida Maia, PhD Pelvic floor exercises can help make sex more enjoyable, study finds Pelvic floor exercises, which strengthen the muscles around the bladder, bowel, and vagina, can help with sexual health and lessen sex-related distress in women with multiple sclerosis (MS), a small study found. Women reported increased sexual desire, arousal, and better overall satisfaction after engaging in a 12-week training program,…
February 7, 2024 News by Marisa Wexler, MS New MRI technique allows for more precise imaging of myelin sheath Scientists have developed a technique to more precisely map the myelin sheath, the fatty covering around nerve fibers that is damaged in multiple sclerosis (MS), in people undergoing an imaging scan. While further work is needed, its use “produced promising initial results,” the scientists wrote, noting that this…