News

STAT5 Protein Complex Implicated in MS Autoimmunity in Mice

A four-protein complex, or tetramer, of the protein STAT5 is involved in the development of multiple sclerosis (MS)-like autoimmune disease in mice, a new study shows. The findings point to this protein complex and its signaling pathway as a potential treatment in MS and other autoimmune conditions, scientists noted.

Scientists Review State of Cannabis Research in MS

Treatment with cannabis-based medications may ease muscle spasms, decrease pain, and aid in sleep for people with multiple sclerosis (MS), but more research is needed to evaluate the potential benefits of cannabis use. That is the finding of a team of U.S. researchers who published a review paper, “…

Stem Cell Transplant Gaining Ground as MS Therapy Option

Nothing was working for Jennifer Stansbury Koenig, who was diagnosed with relapsing-remitting multiple sclerosis (RRMS) in 2010 the day before she learned she was pregnant. The first disease-modifying therapy (DMT) Koenig started in 2013, Tecfidera (dimethyl fumarate), an oral capsule developed and marketed by Biogen, made her…

3D Showing of Mayzent Binding to Receptor Could Advance Treatments

For the first time, researchers have brought to light the precise three-dimensional structure of Mayzent (siponimod) as it binds to its molecular target, the sphingosine 1-phosphate receptor 1 (S1P1). These findings are expected to aid in developing next-generation MS therapeutics with better selectivity for S1P1, enhancing their potency while reducing…

MS Doctors, Nurses in UK Struggle With Marking Transition to SPMS

Among healthcare providers in the U.K., considerable variation exists in marking the transition from relapsing-remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS), a study based on interview responses reports. Neurologists and nurses with MS specialties also expressed a reluctance to label patients as having progressed to…

MS Focus of Paralyzed Veterans of America’s Newest Committee

Paralyzed Veterans of America (PVA) has formed a committee to better address the needs and interests of veterans with multiple sclerosis (MS), including help with obtaining care and disability benefits. The nonprofit PVA is the only congressionally chartered veterans organization working to assist and represent veterans with spinal…

NervGen Cleared to Enroll 2nd MAD Group in NVG-291 Trial

NervGen Pharma has been cleared to enroll a second group of healthy volunteers into the multiple ascending dose portion of its Phase 1 clinical trial of NVG-291, a therapeutic candidate for multiple sclerosis (MS). The trial’s Safety Review Committee approved the second group after seeing promising safety data…

BCG Vaccine for TB Not Linked to MS Risk: Large Canadian Study

Getting the Bacillus Calmette-Guerin (BCG) vaccine to protect against tuberculosis (TB) — an immunization often given to infants and small children in countries where TB is common — does not decrease a person’s risk of developing multiple sclerosis (MS), according to a new study. “Within a large birth cohort…

Novantrone Lowers Relapses, Eases Disability in Highly Active RRMS

Initial treatment with Novantrone (mitoxantrone) can reduce the risk of relapses and worsening disability in people with highly active relapsing-remitting multiple sclerosis (RRMS), according to a 10-year study from France. “Our results support the short-term use of [Novantrone], followed by a maintenance therapy for patients with early highly…

MS Read-a-Thon in Canada Extended to Meet Goal

The MS Society of Canada‘s virtual MS Read-a-Thon event has been extended to March 20, giving children and families throughout Canada extra time to enjoy reading while raising funds for the multiple sclerosis (MS) community. The event, which began Jan. 27, seeks to generate $110,000 to…

FDA Clears Leg-worn ‘Neural Sleeve’ to Aid Walking

Cionic has received authorization from the U.S. Food and Drug Administration (FDA) to market its lightweight, leg-worn Neural Sleeve to improve walking in people with multiple sclerosis (MS) and other conditions that affect mobility. The decision comes four months after the company submitted the device — the first to…

Worsening Disability in Absence of Relapses ‘Underestimated’ in MS

A substantial amount of disability worsening happens independently of relapses in people with multiple sclerosis (MS), including those in earlier stages of relapsing-remitting disease, a study in a large patient database reported. While its findings “confirm relapses contribute to the accumulation of disability, primarily early in multiple sclerosis,” data…

Ketogenic Diet Eases Symptoms, Aids Life Quality in Small RRMS Study

A short-term ketogenic diet, which dramatically cuts carbohydrate consumption, is safe and results in significant improvements in people with relapsing-remitting multiple sclerosis (RRMS), a small study in patients reported. “Our study provides evidence that a ketogenic diet is safe and beneficial, reducing some symptoms for people with MS, when…

Stem Cell Therapy NG-01 Shows Neuroprotective Effects in Trial

Administering the stem cell therapy NG-01 — designed to have neuroprotective and neuro-regenerative properties — directly into the spinal canal can significantly reduce the levels of neurofilament light chain (NfL), a neuronal damage biomarker, in people with active, progressive forms of multiple sclerosis (MS). These are the new…

Using Trait Mindfulness Techniques May Help Reduce Depression in MS

Multiple sclerosis (MS) patients reported fewer difficulties regulating their emotions, and reduced depressive symptoms when they applied trait mindfulness techniques, a study showed. Trait mindfulness refers to an innate ability to pay and maintain attention to moments in the present with an open, non-judgmental attitude. Notably, the use of…

Masitinib Slows Disability Progression in PPMS, Non-active SPMS

Masitinib, AB Science’s experimental oral therapy, significantly slows disability progression in adults with primary progressive multiple sclerosis (PPMS) and non-active secondary progressive MS (SPMS), according to final data from the AB07002 Phase 2b/3 clinical trial. These findings, indicating that the trial met its main goal, support…

#ACTRIMS2022 – Blood NfL Levels May Help Quantify Relapse Severity

Measuring levels of the neurofilament light chain (NfL) protein in blood may be a way to “quantify” relapse severity and predict future disability in people with relapsing-remitting multiple sclerosis (RRMS). “Higher [blood] NfL levels during periods of active inflammation predicted more [brain] atrophy,” researchers wrote in an abstract titled…

Questions to Ask Your Doctor If You’re Newly Diagnosed

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We consulted some of our community contributors at MS News Today and came up with 12 questions people should consider asking their doctors after an MS diagnosis.

Check it out by clicking here.

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