MS News that Caught My Eye Last Week: Bafiertam, Stem Cell Transplant Damage, Gilenya Study, NurOwn Benefits
***autologous hematopoietic stem cell transplant (aHSCT) can cause “transient” damage to neurons and supporting cells of the central nervous system in people with aggressive multiple sclerosis (MS), a Canadian study reports. Nonetheless, its researchers believe that the risk of such neuronal toxicity is offset by the benefits of the aHSCT procedure in aggressive MS cases. Click here to read the full story.
***Gilenya (fingolimod) for eight or more years show smaller increases in disability over 10 years than those using this treatment for a shorter time, a long-term follow-up study reports. Longer use of Gilenya also resulted in lesser disability progression, a reduced reliance on walking aids or wheelchairs, and fewer people transitioning to secondary progressive multiple sclerosis (SPMS) over the 10 years of follow-up. Click here to read the full story.
***mesenchymal stem cells (MSC), expanding them, and maturing them into cells that produce high levels of compounds that promote nerve-tissue growth and survival. The cells are then injected back into the spinal canal. Researchers think this process can help repair nerve cells and prevent further damage. It may also have an effect on B- and T-cells, both of which are believed to have a role in the MS disease process. A small Phase 2 trial is under way at the Cleveland Clinic. NurOwn, believed to have neuroprotective and repairing effects, may also be able to curb the damaging immune responses that contribute to multiple sclerosis (MS) progression, a recent study found. This newly identified potential may extend the benefits of this cell-based therapy, its researchers believe. Click here to read the full story.
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