MS News That Caught My Eye Last Week: Cure Connections, PIPE-307, Temelimab, EHP-101

NeurologyLive, CMSC Launch Expert Video Series ‘Cure Connections’

This series of 13 videos, designed for healthcare professionals, focuses on diagnosing MS, its psychological impact, managing symptoms, and treatments. Quality-of-life issues, fatigue, and patient support networks also will be discussed. I hope general neurologists will watch it, not just MS specialists, as many general neurologists seem out of touch with the ins and outs of diagnosing and treating multiple sclerosis. Just ask their patients.

NeurologyLive and the Consortium of Multiple Sclerosis Centers (CMSC) have launched a new video series called Cure Connections, designed to provide healthcare professionals with expert news and insights about multiple sclerosis (MS).

“These past several months our partnership with the CMSC has escalated to producing and disseminating extremely important education for neurology professionals everywhere,” Mike Hennessy Jr., president and CEO of MJH Life Sciences, NeurologyLive‘s parent company, said in a press release.

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Pipeline Testing PIPE-307 Remyelinating Compound in Healthy Volunteers

Here’s a remyelination study being done on real people, not just mice. It’s only in Phase 1, meaning only safety is being tested, but it’s great news that this investigative treatment has moved out of the lab and into the clinic. Hopefully, Phase 2 won’t be too far down the road.

Pipeline Therapeutics has initiated a Phase 1 clinical trial to investigate PIPE-307, its lead treatment candidate for multiple sclerosis (MS), in healthy volunteers.

The trial (NCT04725175) will assess the compound’s safety, tolerability, and pharmacokinetics, or how the drug moves through the body. Up to 72 people, ages 18 to 55, will be enrolled at the trial’s single testing center in Western Australia. Recruitment is ongoing; more information can be found here.

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Safety Board Says Phase 2 Temelimab Trial Should Move Forward

Getting the Phase 2 go-ahead from the Drug Safety Monitoring Board is temelimab, a monoclonal antibody that targets the viral protein pHERV-W. The hope is that temelimab will prevent that protein from activating the rogue immune response that damages myelin.

A Phase 2a clinical trial evaluating GeNeuro‘s investigational antibody temelimab as a treatment for relapsing multiple sclerosis (MS) should continue as planned, without modifications.

That’s the recommendation of a Drug Safety Monitoring Board, an independent committee of clinical research experts, which was evaluating the trial of the relapsing MS therapy candidate, the company announced in a press release.

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Emerald Health Preparing for Phase 2 Trial of EHP-101 for Relapsing MS

EHP-101 is an oral medication whose goal is to reduce MS inflammation and promote remyelination. Its active ingredient is CBD, the non-hallucinogenic part of the cannabis plant.

Emerald Health Pharmaceuticals (EHP) is preparing for an international Phase 2 clinical trial testing EHP-101 for the treatment of multiple sclerosis (MS).

The study will take place in about 20 locations in the U.S. and Australia, and is expected to include approximately 50 patients with relapsing forms of MS — relapsing-remitting and relapsing secondary progressive MS. Enrollment is expected to begin later this year.

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