Columns The MS Wire - A Column by Ed Tobias MS News That Caught My Eye Last Week: Evusheld, Immunotherapy, Blood Test, Aubagio MS News That Caught My Eye Last Week: Evusheld, Immunotherapy, Blood Test, Aubagio by Ed Tobias | June 13, 2022 Share this article: Share article via email Copy article link Evusheld Boosts Antibodies Against COVID-19 in Vaccinated Patients Research has shown that the COVID-19 vaccines have been effective for people being treated with disease-modifying therapies, except for those that target B-cells, such as Ocrevus (ocrelizumab), Kesimpta (ofatumumab), and Rituxan (rituximab). If this very small study of 18 people proves true, it will be excellent news for those in the B-cell group. Evusheld seems like something for them to ask their neurologists about. Treatment with Evusheld (tixagevimab co-packaged with cilgavimab) after COVID-19 vaccination significantly boosted the levels of antibodies against the virus among people with multiple sclerosis (MS) who were taking B-cell targeted therapies, a small study showed. āThis is important as it provides a different strategy for protection against COVID-19,ā the scientists wrote. Recommended Reading May 26, 2022 News by Marisa Wexler, MS Lesions in 3 Brain Regions Can Help Distinguish MS From Like Disorders *** Phase 1/2 Trial Is Testing Cutting-edge Immunotherapy in MS Patients Extracorporeal photopheresis is described by these researchers as cell-based immunotherapy used to treat certain T-cell lymphomas ā things such as complications from bone marrow and stem cell transplants and organ transplant rejection. Now it will be tried in a small group of people with MS. This approach doesn’t globally suppress the immune system like several of our disease-modifying therapies, so the body may be better able to fight infections during treatments. A Phase 1/2 clinical trial is evaluating the safety and effectiveness of a cutting-edge immunotherapy called extracorporeal photopheresis in people with multiple sclerosis (MS). The study, dubbed PHOMS (NCT05168384), is enrolling up to 45 adults with relapsing-remitting MSĀ and secondary progressive MS at a single site, the Abu Dhabi Stem Cells Center, in Dubai. *** Blood Test to Monitor MS Activity Supports Optimal Care, Octave Says Is this a tool that can be added to MRIs and physical exams to track MS activity? The blood test’s developers say it monitors immune modulation, neuroinflammation, myelin biology, and neuroaxonal integrity. It then generates scores related to disease pathways and overall disease activity. A blood biomarker test developed by Octave can effectively monitor overall disease activity in people with multiple sclerosis (MS), helping to improve the care being given, the company reported. The assay, dubbed the MS Disease Activity (MSDA) test, can also be used to monitor disease activity across a patient population, meaning an entire group of MS patients treated at a given clinic or healthcare facility, Octave added. *** No Disease Activity for 58% of Those on Aubagio After 2 Years: Study No evidence of disease activity (NEDA) means no relapses, no worsening disability, and no signs of new inflammatory damage on MRI scans. Interestingly, the analysis in this study shows the likelihood of NEDA after two years of Aubagio treatment was highest for those who were younger and had milder disability and fewer relapses before they started Aubagio. That gives support to the belief that it’s best to start treatment with a disease-modifying therapy early following an MS diagnosis. More than half of the people with multiple sclerosis (MS) treated withĀ Aubagio (teriflunomide) showed no evidence of disease activity after two years on treatment, according to a study in Italy. The study, āEvolution of teriflunomide use in multiple sclerosis: A real-world experience,ā was published in theĀ Journal of the Neurological Sciences. Note:Ā Multiple Sclerosis News TodayĀ is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those ofĀ Multiple Sclerosis News TodayĀ or its parent company, BioNews, and are intended to spark discussion about issues pertaining to multiple sclerosis. Print This Page About the Author Ed Tobias People say to write what you know and Ed Tobias knows about MS. He's lived with the illness since 1980, when he was 32 years old. Ed's a retired, award-winning broadcast journalist and his column combines his four decades of MS experiences with news and comments about the latest in the MS community. In addition to writing his column, Ed is one of the patient moderators on the MS News Today Facebook, Twitter, and Instagram sites. Heās also the author of āThe Multiple Sclerosis Toolbox: Hints and Tips for Living with M.S.ā Ed and his wife split their time between the Washington, D.C. suburbs and Floridaās Gulf Coast, trying to follow the sun. Tags Aubagio, clinical trial, COVID-19, immunotherapy, relapsing remitting multiple sclerosis, secondary progressive multiple sclerosis, teriflunomide Comments Leave a comment Fill in the required fields to post. Your email address will not be published. Your Name Your Email Your Comment Post Comment