Clene Nanomedicine‘s remyelination therapy candidate, CNM-Au8, showed a “robust” ability to stimulate the production of new myelin and increase the number of myelin-wrapped nerve fibers in the brain and spinal cord of animals in models of demyelinating disease, allowing mice to recover motor skills, a study reports.
Such preclinical data support the efficacy of this potential treatment, now being tested in clinical trials with multiple sclerosis (MS) patients.
These early findings were reported in the study “Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis,” published in the journal Nature Scientific Reports.
In MS, the immune system attacks myelin, the protective sheath around nerve fibers or axons. Myelin is essential for the fast transmission of electrical signals between neurons, and its loss (demyelination) damages the integrity of nerve cells and their ability to communicate with each other.
Finding therapies that promote remyelination — the recovery of myelin — is a “high priority” for MS, the researchers noted. Such treatments could potentially repair demyelinating lesions in the central nervous system (the brain and spinal cord), restoring function to nerve cells affected by the disease.
Most approved MS therapies dampen the immune system’s activity to prevent further myelin damage. However, they cannot undo existing damage or replace the myelin sheaths that have been lost.
CNM-Au8 is a solution of gold (Au) nanoparticles with a patented crystal structure, named a clean-surfaced nanocrystal (CSN). According to the company, these nanocrystals have properties that make them “highly biologically active,” allowing them to facilitate certain energy-related reactions within cells.
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?