Mayzent (siponimod) significantly improved cognitive processing speed in people with secondary progressive multiple sclerosis (SPMS) compared with a placebo, according to additional analyses of two-year data from the EXPAND Phase 3 trial.
While no approved therapies in the U.S. currently target cognitive impairment in MS, “our study found that [Mayzent], which is prescribed to slow the progression of physical disability in MS, may also help improve cognitive processing speed in people with advanced MS,” Ralph H. B. Benedict, PhD, the study’s first author, said in a press release.
Benedict is a professor of neurology at the University of Buffalo in New York, and a member of the American Academy of Neurology.
Since significant improvements were seen in only one of the three cognitive function tests included in the trial, “more research should further examine how [Mayzent] affects scores on a broader array of thinking and memory tests,” Benedict added.
These findings were reported in the study, “Siponimod and cognition in secondary progressive multiple sclerosis: EXPAND secondary analyses,” published in the journal Neurology.
Cognitive difficulties are estimated to affect a vast majority of MS patients, and are usually more severe in progressive than in relapsing forms of the disease. Impairment is associated with a considerable negative impact on patients’ quality of life, with processing speed as the most commonly affected cognitive domain.
Cognitive processing speed is the amount of time it takes a person to take in information, process it, and then react to solve a problem or complete a task.
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