December 1, 2023 News by Lindsey Shapiro, PhD Presence of damaged myelin may be more harmful than its loss: Study The presence of damaged myelin ā the fatty, protective substance surrounding nerve cells that’s lost in multiple sclerosis (MS) ā may be more harmful to nerve cells than its removal altogether, according to new preclinical research. In mouse models of myelin-associated disease, a failure of microglia ā the…
July 6, 2023 News by Lindsey Shapiro, PhD Myelin may promote nerve cell damage in early immune attacks Nerve cells coated with myelin ā the fatty substance that’s lost in multiple sclerosis (MS) ā may be more vulnerable to degeneration in an inflammatory environment than cells lacking myelin, researchers working in MS patient tissues and mouse models report. The scientists believe the phenomenon arises when certain…
April 25, 2023 News by Marisa Wexler, MS Possible treatment target in myelin damage, inflammation pathway Damage to the myelin sheath, a hallmark feature of multiple sclerosis (MS), leads to increased levels of fatty molecules called VLCFAs, which are converted by brain cells into an inflammation-driving signaling molecule called S1P, a study suggests. The discovery of this novel molecular pathway may open up new avenues…
March 17, 2022 News by Patricia Inacio, PhD NervGen Cleared to Enroll 2nd MAD Group in NVG-291 Trial NervGen Pharma has been cleared to enroll a second group of healthy volunteers into the multiple ascending dose portion of its Phase 1 clinical trial of NVG-291, a therapeutic candidate for multiple sclerosis (MS). The trial’s Safety Review Committee approved the second group after seeing promising safety data…
November 18, 2021 News by Marisa Wexler, MS Cholesterol Made by Nerve Cells Repairs Myelin Damage in Mice Cholesterol made by neurons is crucial for repairing long-term damage to the myelin sheath, the fatty coating around nerve fibers that is damaged in multiple sclerosis (MS), according to a new report based on experiments done on mice. The finding suggests that increasing neuronal cholesterol synthesis may be helpful…
February 21, 2020 Columns by Ed Tobias Myeliviz Brings Hope for Faster MS Diagnosis Myeliviz is the name of a new compound approved for a clinical trial in the U.S. that has the potential to make the process of diagnosing multiple sclerosis faster and tracking the disease progression easier. It does this by providing doctors with a better picture of damaged myelin ā…
June 27, 2018 News by Patricia Inacio, PhD New Fluorescent Imaging Tool Allows Researchers to Track Immune Cell Dynamics in MS Mouse Model A new fluorescent imaging strategy allows researchers to track T-cells and further understand their dynamics in vivo, giving them insight into what happens when these immune cells attack myelin in a mouse model of multiple sclerosis (MS). The new technology was reported in the study, āA timer for…