Non-psychoactive cannabidiol (CBD), one of the active compounds in medical cannabis, significantly reduced clinical signs of multiple sclerosis (MS)-like disease in an experimental autoimmune encephalomyelitis mouse model. Researchers found that CBD promoted the increase of inflammatory-suppressor cells called myeloid-derived suppressor cells.
The findings were reported in the study “Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells,” published in the journal Frontiers in Immunology.
Medical cannabis contains more than 100 pharmacologically active compounds (called cannabinoids), which have been shown to exert potent anti-inflammatory effects and to be potential therapies for a number of autoimmune diseases, including MS.
In MS, evidence supports the potential of CBD, one of the most studied cannabinoids, along with tetrahydrocannabinol (THC), to modulate spasticity, as well seizures, inflammation, pain, anxiety, and other conditions. The fact that CBD does not have the psychoactive properties (the so-called “high”) that accompany THC, makes it a more attractive therapeutic.
Moreover, CBD has been reported to have neuroprotective effects, halting brain inflammation. However, the mechanisms through which CBD suppresses neuroinflammation in MS remain unknown.
Now, researchers at the University of South Carolina School of Medicine used the MS mouse model, called experimental autoimmune encephalomyelitis (EAE) model, to evaluate the effects of treatment with CBD on neuroinflammation.
The team focused on a group of cells called the myeloid-derived suppressor cells. These cells suppress inflammation and are thought to play a critical role in suppressing neuroinflammation in MS.
From the moment EAE mice began developing clinical signs of MS (day nine after EAE’s induction), researchers gave them daily doses of CBD, administered intraperitoneally (into the abdomen) at a dose of 20 mg/kg. Treatment continued until the end of the study (day 25).
We are sorry that this post was not useful for you!
Let us improve this post!
Tell us how we can improve this post?