September 14, 2023 News by Marisa Wexler, MS ‘Inverse vaccine’ approach lowers disease in MS mouse model Note: This story was updated Sept. 15, 2023, to clarify ANK-700 was developed based on the preclinical work described in the study. An “inverse vaccine” that’s designed to teach the immune system not to attack a specific target, effectively reduced disease activity in mouse models of multiple sclerosis (MS),…
August 17, 2023 News by Lindsey Shapiro, PhD Benefits of intranasal Nogo-A antibody observed in mouse model Delivering an antibody against the Nogo-A protein to a specific region of the nose called the olfactory mucosa improved motor function and preserved myelin in the spinal cord of a mouse model of multiple sclerosis (MS), according to a recent study. This intranasal mode of delivery enabled significant concentrations…
August 16, 2023 News by Lindsey Shapiro, PhD Engineered probiotic found to ease symptoms in mouse model of MS A lab-engineered probiotic, composed of live bacteria that colonize the gut, was able to ease signs of disease in a mouse model of multiple sclerosis (MS), according to recent research. After discovering that a metabolite called lactate could activate immune signaling pathways that help to curb autoimmunity, scientists specifically…
July 13, 2023 News by Marisa Wexler, MS Inflammation in brain membranes may act as trigger in MS: Study Inflammation in the membranes around the brain may trigger an inflammatory response that can spread into nearby brain tissue, a new study in a mouse model of multiple sclerosis (MS) shows. Researchers say these findings may help to advance scientists’ understanding of the mechanisms that underlie brain damage in…
July 13, 2023 News by Lindsey Shapiro, PhD XPro1595 may promote myelin restoration, new mouse study finds INmune Bio‘s experimental therapy XPro1595 may promote myelin restoration through the activation of two types of nervous system support cells, according to new data that may lead to novel treatment strategies for multiple sclerosis (MS) and other neurodegenerative disorders. The findings highlight the activation of microglia, key…
June 6, 2023 News by Marisa Wexler, MS Novel immune cell strategy found to reverse disease in MS mice Microparticles that activate regulatory T-cells, or Tregs, an immune cell type with anti-inflammatory properties, reversed the accumulation of physical disability due to multiple sclerosis (MS) in a mouse model of the neurodegenerative disorder, a new study shows. Use of the novel strategy even cured some of the animals. “We…
May 22, 2023 News by Steve Bryson, PhD Periods of oxygen deprivation improve symptoms of MS in mice A non-invasive treatment called acute intermittent hypoxia, or AIH, involving periods of oxygen deprivation, was found to ease signs and symptoms of progressive multiple sclerosis (MS) in a mouse model of the disease. Given during the peak of disease activity, AIH treatment ā basically, periods of reduced oxygen exposure…
February 16, 2023 News by Marisa Wexler, MS Omega-3 fatty acid reduced disease severity in MS mouse model Treatment with docosahexaenoyl ethanolamide (DHEA), an omega-3 fatty acid found in fish oil, reduced inflammation and disease severity in a mouse model of multiple sclerosis (MS). These findings suggest that “an increase of omega-3 consumption may be beneficial to patients diagnosed with MS,” researchers said. “We believe our findings…
January 27, 2023 News by Steve Bryson, PhD Fractalkine Found to Promote Remyelination in MS Mouse Model The signaling protein fractalkine was found to promote the repair of myelin ā the protecting coating around nerve fibers ā that is damaged by the mistaken immune attack that leads to multiple sclerosis (MS), a mouse study demonstrated. In an animal model of the disease, the molecule…
January 13, 2023 News by Marisa Wexler, MS Exosome-based Therapy Eases Disease in MS Mouse Model A new therapy that delivers an anti-inflammatory compound to nervous system immune cells via cellular “shipping containers” called exosomes showed promise in a mouse model of multiple sclerosis (MS), a study reports. The study,Ā “Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia,” was published in the…
December 22, 2022 News by Marisa Wexler, MS Cutting Brain-gut Vagus Nerve Lessens Loss of Myelin in MS Mice Severing the lower part of the vagus nerve ā one of the main neurological pathways that connects the brain to the gut ā led to less myelin loss in a mouse model that’s commonly used to study multiple sclerosis (MS). The findings suggest that the vagus nerve plays…
December 16, 2022 News by Marisa Wexler, MS Foralumab Nasal Spray for MS Well-tolerated in Mice for 3 Months Foralumab, a nasal spray therapy that Tiziana Life Sciences is developing for multiple sclerosis (MS) and other disorders, was well-tolerated in mice for more than three months, according to data from a preclinical study. Tiziana is planning to share that data in a meeting with the U.S. Food…
November 29, 2022 News by Marisa Wexler, MS Removing Transporter Protein Spns2 Protects Against MS in Mice Blocking the activity of Spns2, a transporter of the sphingosine 1-phosphate (S1P) protein, reduced the severity of multiple sclerosis (MS) in a mouse model, a new study shows. The findings point to Spns2 as a new molecular target for MS treatments that could reduce the side effects associated…
August 22, 2022 News by Marta Figueiredo, PhD MS Spasticity Therapy Baclofen Helps to Repair Myelin: Early Study Baclofen, an approved therapy for spasticity in multiple sclerosis (MS) patients, promoted the repair of myelin ā the protective sheath around nerve fibers that’s progressively lost in MS ā in a mouse model of the disease, a study showed. These findings suggest baclofen ā sold as oral tablets,…
July 21, 2022 News by Marisa Wexler, MS Semi-synthetic Compound Promotes Myelin Repair in MS Mice A man-made molecule derived from a naturally occurring amino acid was able to promote the repair of the myelin sheathĀ ā a fatty coating around nerve fibers that is damaged in multiple sclerosisĀ ā in a mouse model of the disease, a new study reports. “These findings suggest that ……
June 1, 2022 News by Marisa Wexler, MS New Scale May Better Assess MS Changes, Therapy Response in Mice A new scoring system might more precisely evaluate disease development, severity, and treatment response in a commonly used mouse model of multiple sclerosis (MS) known as the experimental autoimmune encephalomyelitis or EAE model, scientists report. This scoring system, called “I AM D EAE,”Ā was described in the study, “…
May 11, 2022 News by Marisa Wexler, MS Treatment With XPro1595 Promotes Remyelination in Mouse Model The experimental therapy XPro1595 was found to promote remyelination ā the repair of the myelin sheath ā in a mouse model of myelin loss, new data show. Myelin, the fatty covering that helps nerve fibers send electrical signals, is damaged by the immune system inĀ …
May 4, 2022 News by Lindsey Shapiro, PhD Maresin-1 Molecule Eases Inflammation, Symptoms in Mouse Model Administering the maresin-1 molecule ā a natural anti-inflammatory in the body ā in a mouse model of multiple sclerosis (MS) led to lower levels of inflammation and improved neurological function, a recent study showed. Maresin-1 and other molecules in its family are called specialized pro-resolving mediators (SPMs) and are…
February 28, 2022 News by Marisa Wexler, MS #ACTRIMS2022 ā In New Mouse Model, Evobrutinib Shows Efficacy Researchers developed a new mouse model that more closely captures a specific type of inflammation characteristic of progressive multiple sclerosis (MS) ā and found, in experiments, that treatment with an oral medicationĀ called evobrutinibĀ can lessen disease activity. This new mouse model may help scientists in MS to better study…
December 22, 2021 News by Marta Figueiredo, PhD New Subset of Regulatory B-cells May Help MS, Mouse Study Shows Treatment with a newly discovered subset of regulatory B-cells (Bregs) ā a type of immune cell that dampens immune responses ā significantly reduced symptoms in a mouse model of multiple sclerosisĀ (MS), a study shows. Similar effects were observed in a mouse model of uveitis, an inflammatory eye disease triggered…
December 10, 2021 News by Marta Figueiredo, PhD Researchers Identify Subset of Immune Cells Driving MS A new subset of type 3 innate lymphoid cells (ILC3s) ā a type of immune cell known mostly for its anti-inflammatory and immunosuppressive effects in the gut ā infiltrates the brain and promotes the abnormal immune attacks that drive multiple sclerosisĀ (MS), according to a study in a mouse model…
December 6, 2021 News by Patricia Inacio, PhD Lucid-MS Restores Motor Function in Mouse Model, Company Says Lucid-MS, a new chemical molecule being developed by FSD Pharma for the treatment of multiple sclerosis (MS), has shown the ability to restore motor function in an animal model of the disease, the company announced. After about 50 days of treatment, animals receiving Lucid-MS showed a marked decrease…
September 13, 2021 News by Marta Figueiredo, PhD Pro-inflammatory Th17 Immune Cells Harm Myelin-producing Cells Pro-inflammatory T helper 17 cells, known as Th17 cells ā a type of immune cell known to play a role in multiple sclerosis (MS) ā directly interact with myelin-producing cells, promoting their damage and death, according to a study in a mouse model of MS and in samples from…
March 11, 2021 News by Margarida Maia, PhD Vitamin D Supplements at Preclinical Stage Prevented MS in Mice Vitamin D, but not paricalcitol (a vitamin D analog), can be used as a preventive measure to control the severity of multiple sclerosis (MS), according to a new study of mice. The study, āPreclinical therapy with vitamin D3 in experimental encephalomyelitis: Efficacy and comparison with paricalcitol,ā was…
March 3, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Reduced Methionine in Diet Eased Symptoms in MS Mice Editorās note: TheĀ Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25ā27. GoĀ hereĀ to see the latest stories from the conference. Reducing the essential amino acid methionine in the diet lessenedĀ multiple sclerosis (MS)-like symptoms in a mouse model of…
February 19, 2021 News by Marta Figueiredo, PhD MS-linked Molecule IL-17 Impaired Immune Cells in Mice’s Brains Sustained, excessive levels of interleukin 17A (IL-17A) ā a pro-inflammatory molecule linked to multiple sclerosisĀ (MS) and other autoimmune diseases ā reduce the number and activity of the brainās immune cells in the dentate gyrus, according to a study in mice. The dentate gyrus is part of the hippocampus, a…
February 12, 2021 News by Diana Campelo Delgado Early-life Trauma Affects MS Development, Treatment in Mice Childhood trauma can affect disease progression of multiple sclerosis (MS) and treatment in adulthood, a study in mice suggests. The study shows that mice that experienced early-life trauma were more likely to develop an autoimmune condition and less likely to respond to common treatment with interferon beta. The study,…
January 27, 2021 News by Marta Figueiredo, PhD Mouse Study Links Cortical Inflammation to Immune Cell Destruction Multiple sclerosis (MS)-associated inflammation in the cerebral cortex ā the outermost layer of the brain that is involved in cognitive function ā prompts the destruction of neural connections by specific immune cells, according to a study in a mouse model of MS. These immune cells targeted dendritic spines (nerve…
December 17, 2020 News by Patricia Inacio, PhD Restoring Neuregulin-1 beta 1 Protein Levels May Help Halt MS Progression The levels of a protein called Neuregulin-1 beta 1 (Nrg-1beta1) decline with the onset and progression of multiple sclerosis (MS), a new study suggests. The findings support the potential of Nrg-1beta1 as a predictor of MS risk and progression and suggest that restoring its levels may help halt disease…
October 23, 2020 News by Forest Ray PhD VX-765 Therapy, Given Through Nose, Limits MS Progression in Early Study The anti-inflammatory medication VX-765, which is delivered through the nose (intranasal), was found to limit disease progression in a preclinical model of multiple sclerosis (MS) by blocking a protein called caspase-1. The medication helped prevent damage to brain cells in mice. Researchers from the University of…