mouse model

XPro1595 may promote myelin restoration, new mouse study finds

INmune Bio‘s experimental therapy XPro1595 may promote myelin restoration through the activation of two types of nervous system support cells, according to new data that may lead to novel treatment strategies for multiple sclerosis (MS) and other neurodegenerative disorders. The findings highlight the activation of microglia, key…

Novel immune cell strategy found to reverse disease in MS mice

Microparticles that activate regulatory T-cells, or Tregs, an immune cell type with anti-inflammatory properties, reversed the accumulation of physical disability due to multiple sclerosis (MS) in a mouse model of the neurodegenerative disorder, a new study shows. Use of the novel strategy even cured some of the animals. “We…

Periods of oxygen deprivation improve symptoms of MS in mice

A non-invasive treatment called acute intermittent hypoxia, or AIH, involving periods of oxygen deprivation, was found to ease signs and symptoms of progressive multiple sclerosis (MS) in a mouse model of the disease. Given during the peak of disease activity, AIH treatment ā€” basically, periods of reduced oxygen exposure…

Omega-3 fatty acid reduced disease severity in MS mouse model

Treatment with docosahexaenoyl ethanolamide (DHEA), an omega-3 fatty acid found in fish oil, reduced inflammation and disease severity in a mouse model of multiple sclerosis (MS). These findings suggest that “an increase of omega-3 consumption may be beneficial to patients diagnosed with MS,” researchers said. “We believe our findings…

Exosome-based Therapy Eases Disease in MS Mouse Model

A new therapy that delivers an anti-inflammatory compound to nervous system immune cells via cellular “shipping containers” called exosomes showed promise in a mouse model of multiple sclerosis (MS), a study reports. The study,Ā “Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia,” was published in the…

Semi-synthetic Compound Promotes Myelin Repair in MS Mice

A man-made molecule derived from a naturally occurring amino acid was able to promote the repair of the myelin sheathĀ ā€” a fatty coating around nerve fibers that is damaged in multiple sclerosisĀ ā€” in a mouse model of the disease, a new study reports. “These findings suggest that ……

New Scale May Better Assess MS Changes, Therapy Response in Mice

A new scoring system might more precisely evaluate disease development, severity, and treatment response in a commonly used mouse model of multiple sclerosis (MS) known as the experimental autoimmune encephalomyelitis or EAE model, scientists report. This scoring system, called “I AM D EAE,”Ā was described in the study, “…

Maresin-1 Molecule Eases Inflammation, Symptoms in Mouse Model

Administering the maresin-1 molecule ā€” a natural anti-inflammatory in the body ā€” in a mouse model of multiple sclerosis (MS) led to lower levels of inflammation and improved neurological function, a recent study showed. Maresin-1 and other molecules in its family are called specialized pro-resolving mediators (SPMs) and are…

#ACTRIMS2022 ā€“ In New Mouse Model, Evobrutinib Shows Efficacy

Researchers developed a new mouse model that more closely captures a specific type of inflammation characteristic of progressive multiple sclerosis (MS) ā€” and found, in experiments, that treatment with an oral medicationĀ called evobrutinibĀ can lessen disease activity. This new mouse model may help scientists in MS to better study…

Researchers Identify Subset of Immune Cells Driving MS

A new subset of type 3 innate lymphoid cells (ILC3s) ā€” a type of immune cell known mostly for its anti-inflammatory and immunosuppressive effects in the gut ā€” infiltrates the brain and promotes the abnormal immune attacks that drive multiple sclerosisĀ (MS), according to a study in a mouse model…

#ACTRIMS2021 – Reduced Methionine in Diet Eased Symptoms in MS Mice

Editorā€™s note: TheĀ Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25ā€“27. GoĀ hereĀ to see the latest stories from the conference. Reducing the essential amino acid methionine in the diet lessenedĀ multiple sclerosis (MS)-like symptoms in a mouse model of…

Early-life Trauma Affects MS Development, Treatment in Mice

Childhood trauma can affect disease progression of multiple sclerosis (MS) and treatment in adulthood, a study in mice suggests. The study shows that mice that experienced early-life trauma were more likely to develop an autoimmune condition and less likely to respond to common treatment with interferon beta. The study,…