Work Showing Potential of EHP-101 in MS Earns Research Award

Jose Marques Lopes, PhD avatar

by Jose Marques Lopes, PhD |

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Carmen Navarrete, PhD, has been granted a Scientific Innovation Award for her post-doctoral presentation suggesting that theĀ multiple sclerosisĀ (MS) treatment candidateĀ EHP-101Ā is anti-inflammatory and may boost remyelination,Ā Emerald Health PharmaceuticalsĀ announced.

Navarrete, a senior scientist at Vivacell Biotechnology Espana, a company owned by Emerald Health Research, received the award at the 28th Annual International Cannabinoid Research Society (ICRS) Symposium, held in Leiden, The Netherlands.

Her presentation, ā€œEffect of Oral VCE-004.8, a Cannabidiol Quinol Derivative, on Experimental Autoimmune Encephalomyelitis,ā€Ā demonstrated that, in a mouse model of MS, EHP-101 has anti-inflammatory activity and could increase remyelination ā€” the production of the protective myelin cover wrapped around neurons ā€” a key treatment goal in MS.

ā€œWe are very proud of Dr. Navarreteā€™s receipt of this prestigious award for her work on EHP-101,” Jim DeMesa, MD, Emeraldā€™s CEO, said in a press release.

ICRS is a prestigious global organization focused on research on cannabis and cannabinoids, while also acting as a source for impartial information.Ā The award recognizes extraordinary scientific achievements from all fields of cannabinoid research.

ā€œThe recognition of this distinguished award underscores the vision and dedication of the teams behind EHP-101, and further strengthens our pursuit to help patients with these serious, incurable diseases,” DeMesa added.

EHP-101 (previously known as VCE-004.8) is Emeraldā€™s lead product candidate. It is a small molecule based on a new, synthetic cannabidiol (CBD). According to the company, it was designed to have increased therapeutic effectiveness over other CBD products, as it has superior agonist (activating)Ā anti-inflammatory activity via the cannabinoid receptors CB2 and PPAR-gamma. It does so while also playing a role in the HIF signaling pathway, which responds to variations in the amount of oxygen and is involved in remyelination.

Emerald plans to start a Phase 1 clinical trial of orally administered EHP-101 later this year.

Prior research in mice indicated that, besides promoting remyelination, EHP-101 may prevent nerve cell damage, and lower neuroinflammation and the reactivity of immune cells of the brain and spinal cord.

EHP-101 also has shown ability to prevent skin and lung fibrosis (scarring)Ā in a mouse model of scleroderma.

Besides EHP-101, Emerald is developing EHP-102, a derivative of cannabigerol ā€” also a natural cannabinoid ā€” for Parkinsonā€™s and Huntingtonā€™sĀ diseases.

“We believe that EHP-101ā€™s demonstrated potential as a disease-modifying treatment for multiple sclerosis and scleroderma showcases the beginnings of what our industry can achieve,ā€ DeMesa said.