MS News that Caught My Eye Last Week: Cannabis and Inflammation, Exercise and MS, a New MS Subtype

MS News that Caught My Eye Last Week: Cannabis and Inflammation, Exercise and MS, a New MS Subtype

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Cannabidiol Increases Inflammatory Suppressor Cells, New MS Mouse Study Shows

There’s quite a bit of anecdotal evidence that the use of marijuana can help reduce the symptoms of multiple sclerosis (MS). Here’s a report about a study that suggests a reason that could be happening.

Non-psychoactive cannabidiol (CBD), one of the active compounds in medical cannabis, significantly reduced clinical signs of MS-like disease in an experimental autoimmune encephalomyelitis mouse model. Researchers found that CBD promoted the increase of inflammatory-suppressor cells called myeloid-derived suppressor cells.

The findings were reported in the study “Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells,” published in the journal Frontiers in Immunology.

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MS Patients Speak of Importance of Exercise and Activity to Overall Sense of Well-Being in UK Study

I swam 15 laps today and also did some walking in the pool. I felt good the rest of the day. The same is true in cold weather, after I  do some upper-body exercise in the gym. Sometimes, I have to force myself to exercise, but I’m glad that I do. So, I’m not surprised by the comments made by people with MS who were interviewed for this study, but it makes for interesting reading anyway.

People with MS value exercise and physical activity far beyond the concept of “staying fit,” and consider exercise essential to maintaining a reasonable level of independence and being able to engage in social activities, a small U.K. study based on interviews reports. 

The study, “The meaning of exercise and physical activity in community dwelling people with multiple sclerosis,” was published in the journal Disability and Rehabilitation.

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Myelocortical MS, New Disease Subtype Marked by Nerve Cell But Not Myelin Loss, Identified in Study

The results of this Cleveland Clinic research show that contrary to conventional MS wisdom, nerve cells in the brain can die without evidence that myelin has been damaged. Because of this, these doctors are proposing a new MS subtype that may point to a different approach to some treatments.

Researchers have identified a new subtype of MS, one marked by nerve cell degeneration that occurs independently of immune system attacks against myelin, a process known as demyelination and considered a hallmark of MS.

Join the MS forums: an online community for especially for patients with MS.

The new subtype — called myelocortical MS — is indistinguishable from others in the MS spectrum using conventional magnetic resonance imaging (MRI), highlighting the need for more sensitive MRI imaging techniques.

This finding unmasks a previously unknown heterogeneity within MS, and may make possible more personalized therapies for patients.

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Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Multiple Sclerosis News Today, or its parent company, BioNews Services, and are intended to spark discussion about issues pertaining to multiple sclerosis.

4 comments

  1. RE: The most recent cannabis report. So what the hell are they all waiting for? The passing of each inactivated day is demonstration of our legislators’ immoral torpitude. Meanwhile, we, millions of us, MILLIONS of Americans agonize from chronic neuropathies daily. That ain’t Christian compassion, nor is it Hebraic, or Muslim, or Buddhist, or Hindi, or Zen. Capital Hill and the Pharmas are full of dollar-sign crap. What’s the cost of a joint on the street? And, immediate availability. PLEASE, give us all a benevolent, compassionate and empathic break. The side-effects of the Lyricas, et al, are ruining anything left of our lives. Does anyone ever recall anything remotely resembling side-effects such as somnalence, edema, vertigo, water-retention, short-term forgetfulness, destruction of desire or initiative the last time they blew a joint? Somebody’s gotta stop the extortion. Sorry, relocating to Vegas to cease my neuropathic agony is just not do-able. So, I wait in agony exacurbated with demoralizing side-effects.

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