Risk of Kidney Deterioration Low in MS Patients, Study Suggests
The rate of kidney deterioration as a result of bladder dysfunction due to multiple sclerosis (MS) is low, affecting only…
Articles by Patricia Inacio, PhD
Lymphatic Vessels of Brain Carry Messages That Appear to Promote MS, Study Reports
Lymphatic vessels, the “roads” that work to clear waste material from the brain, can also carry messages that direct immune…
GeNeuro to Develop the MS Clinical Program of GNbAC1 Without Servier
GeNeuro announced it has reacquired from Servier the worldwide rights to commercialize and develop the investigational humanized antibody GNbAC1 for the…
Gilenya More Effective Than Avonex in Lowering Relapse Rates, New Lesions in Children with Relapsing MS, Phase 3 Trial Shows
Two years of treatment with oral Gilenya (fingolimod) significantly reduced the rate of relapses when compared to Avonex (interferon beta-1a) intramuscular injections…
Higher Levels of Neurofilament Light Chain in Blood and Cerebrospinal Fluid Found in MS Patients, Supporting its Prognostic Potential
A meta-analysis of 13 case-control studies shows that the levels of the protein neurofilament light chain (NFL) are significantly higher…
Cell-free Mitochondrial DNA in Cerebrospinal Fluid of Progressive MS Patients May Point to Neurodegeneration
Cerebrospinal fluid of progressive multiple sclerosis (MS) patients may carry lower levels of cell-free mitochondrial DNA, according to a team…
Small Molecule TDP6 Activates Myelin Regeneration in Mice with MS, Other Diseases, Study Finds
A small synthetic molecule called TDP6 mimics a natural growth factor and promotes myelin regeneration in a mouse model of…
Cannabidiol Increases Inflammatory Suppressor Cells, New MS Mouse Study Shows
Non-psychoactive cannabidiol (CBD), one of the active compounds in medical cannabis, significantly reduced clinical signs of multiple sclerosis (MS)-like disease in an…
Myelocortical MS, New Disease Subtype Marked by Nerve Cell But Not Myelin Loss, Identified in Study
Researchers have identified a new subtype of multiple sclerosis (MS), one marked by nerve cell degeneration that occurs independently of…
Deregulated RNA Molecules May Contribute to RRMS, Study Finds
The levels of three small, regulatory RNA molecules — long non-coding RNAs — are deregulated in blood samples of patients…
Long-term DMT Use Seen to Lower Likelihood of RRMS Progressing to SPMS in Study
Long-term treatment with disease-modifying therapies (DMTs) appears to lessen the risk of disease worsening in relapsing-remitting multiple sclerosis (RRMS) patients,…
Single Gene Variant May Identify MS Patients at Risk of Liver Damage Linked to Interferon-Beta Use, Study Says
A genetic variant close to a gene called interferon regulatory factor 6 (IRF6) may help to predict those multiple sclerosis (MS)…
Brain Iron Levels Correlate with MS Progression, Disability Risk, Study Shows
Evaluating the local differences in iron accumulation in the deep gray matter of the brain using a special magnetic resonance imaging (MRI)…
Nicotine and Beta-amyloid Work on Immune System in Ways That Ease MS Symptoms, Study Reports
Nicotine, the active agent in tobacco, and amyloid proteins, which underlie Alzheimer’s disease, bind to a receptor present in certain…
Overreactive T-cells Can Transition into T-cells That Control the Immune Response, Study Shows
New research shows that overreactive and tissue-damaging T-cells can transition into regulatory T-cells that help to control the immune system’s…
Winter Months Spent in Sunny Climes Can Lower MS Risk, Study Suggests
Greater exposure to sunlight during the winter months — part of a person’s lifetime exposure to ultraviolet radiation — can…
After Ocrevus Approval, New Therapies May Become Available for MS, Report Suggests
Genentech‘s Ocrevus (ocrelizumab), approved in March 2017, has fueled a sea change in the treatment of multiple sclerosis…
New Fluorescent Imaging Tool Allows Researchers to Track Immune Cell Dynamics in MS Mouse Model
A new fluorescent imaging strategy allows researchers to track T-cells and further understand their dynamics in vivo, giving them insight…
Online Aid for MS Patients with Cognitive Difficulties Now Part of MyMSTeam
MyHealthTeams together with Biogen launched a new online tool center, called MS and Cognition Resource Center, to…
#EAN2018 – Mavenclad Greatly Reduces Risk of RRMS Relapse, Analysis Finds
New retrospective analysis of the Phase 3 CLARITY study (NCT00213135) shows that treatment with Mavenclad (cladribine tablets) improved annualized…
#EAN2018 – Both Brain and Spinal MRIs Needed to Monitor MS Inflammation, Study Says
Magnetic resonance imaging (MRI) used to assess inflammation in multiple sclerosis (MS) patients should include scans of the spinal cord…
#EAN2018 – Levels of Neurofilament Light Chain Can Predict Disease Progression in RRMS, Study Shows
Levels of neurofilament light chain are a reliable predictor of disease worsening and progression in relapsing-remitting MS (RRMS) patients, a new…
Atara Biotherapeutics Study Links Epstein-Barr Virus Infection with MS
Analysis of post-mortem brain samples from multiple sclerosis (MS) patients and healthy individuals (without neurologic disease) showed that while signs…
Discovery of ‘Fiery’ Cell Death Mechanism May Be MS ‘Game-Changer’
Researchers have unveiled a new cell death mechanism called pyroptosis — also known as “fiery death” — as a main…
#CMSC2018 — Inhibiting Oxidative Stress Enzyme Promotes Resealing of Blood-Brain Barrier in MS Mouse Model
Inhibiting an oxidative stress enzyme called myeloperoxidase protects the blood-brain barrier in a mouse model of multiple sclerosis (MS), limiting…
#CMSC2018 – Gains in Functional Abilities Seen in Lemtrada-treated MS Patients Over Six Years, CARE-MS II Extension Study Shows
Patients with active relapsing-remitting multiple sclerosis (MS) continue to show improvement — lesser functional disability across a variety of measures…
#CMSC2018 – New Phase 2 Data Supports Ublituximab in Effectively Lowering Relapses, Depleting B-cells in MS Patients
New results from a Phase 2 trial evaluating TG Therapeutics’ ublituximab continue to support the therapy’s efficacy in treating…
Oryzon Genomics Readies Updates on ORY-2001, Being Tested in MS Patients in Phase 2 Trial
Oryzon Genomics will give updates on its leading investigational product ORY-2001, a brain-targeting epigenetic therapy now in a Phase…
Gut Microbiome May Offer Way to Ease or Halt Brain Inflammation, Study Suggests
Metabolites produced by microbes in the gut can ease inflammation in the central nervous system by limiting the damage done by…
Viral Infection Promotes Factor in T-cells Leading to Brain Tissue Destruction
Infection with lymphocytic choriomeningitis virus triggers expression of a factor called TOX in immune cells strengthening their migration into…