Do High Antibody Levels Mean I’m Protected Against COVID-19?

I receive Ocrevus infusions twice a year which target my B-cells. Although I am fully vaccinated with 2 doses of the Pfizer vaccine, I wonder if there is any data yet for efficacy for those of us who are on Ocrevus.

Sure hope T calls are helping! My antibody test after 2 doses of Pfizer, the second with nasty MS side effects, was ZERO antigens. So disappointed!

So in the spirit of understanding the importance of T-cell activation after vaccination has there been any public health interest in using the existing Adapt-T test which is readily available and comparatively inexpensive to better identify patients with suboptimal vaccine response?

Specifically why is it not good to get an antibody test? Would you lose some of the antibodies protecting you?

So when the CDC says to wear a mask if you are unvaxxed, and implies that those who are immunocompromised are considered unvaxxed if they do not have a typical vaccine response, where are people on anti-CD20 therapies to be? Should we still wear a mask, especially if as you say, antibody tests don't mean anything anyway?

Nice to read. With ppms i know my antibody level isn't that good, what with the b b cell suppressants?

You don't indicate whether you take any immunosuppressive medications and I would be very interested in knowing that.
thanks in advance for your response

I received the one-dose Jenssen vaccine about 2and a half months ago. I was tested yesterday with the quantitative antibodies test against SARS Covid 19 and my numbers are 16 for the Spike antibodies. My sons' results, we were vaccinated on the same date, are over 250. Does this mean he has a better inmune response after the vaccine? We've heard about some people who have had similar results as mine and they have received one dose of the Pfizer vaccine and then they are tested again and get in the range of over 250. Should we try to make our antibodies against the virus grow? Thanks.

I read a recent NYT article about having an ELISA antibody test instead of the standard antibody test after COVID-19 vaccines for people who are immune compromised. My husband has his next Ocrevus infusion 5 weeks after his last Moderna vaccine and I want him to have this test. I’m wondering if you have heard of the ELISA blood test to determine if antibodies were present after the vaccine.

Is it recommended for a person over 70 years old who got COVID-19 and recovered to get vaccine?. The anti-bodies test results after the recovery was 1664.

I had Covid diagnosed on March 4th this year, I got really bad and was given the infusion called Bamlanivimab 700mg , after than I began to recover, slowly but surely. I was told not to do anything for at least 3 months as far as vaccinations, and get tested before my decision as to vacs or not. It has been 4 months and got an antibody test, and it showed a positive 150.1 out of the scale of .7 above positive. So is there any ideas on what to do next, should I take the vaccination Maderna, or should I just wait! I am scared of the shot, but i definitely do not want Covid again, I am a 75 year old almost 76 year old woman, with a thyroid half removed and on blood pressure meds, so I just do not want to do the wrong thing. Do you have any recommendations? We live in the panhandle of Florida, and their is just so many pros and cons. Do you feel the 150.1 is a good positive number? My husband same age had the Moderna 2 vac, and did fine after first shot, than experienced a couple weeks of heart flutters but now better, but he has no health issues at all, so I am just concerned about the heart inflammation issues I have heard about from the shot. Please email me with any help you may offer. Thanks you so much for your time. M.Gregg

I had a blood test to tell me if I had antibodies in my system from having been exposed to COVID 19 in the past. The numbers came back as 12.80, no negative or positive designation, can anyone tell me what those numbers mean?

i had transverse myelitis years ago but im 75% better i had covid a year ago the lab corp test came back at 1100.00 s protien does this correlate with anything. i hope a have some protection still. i really dont want to reactivate the TM again.

I had my second Pfizer shot 10 days ago , and did SARS-CoV-2 S antibody (Roche) test today . My results are :
6162.00 BAU/mL
Only thing I'm not sure : is U/mL the same as BAU/mL

I had my last Pfizer vaccine on March 2nd. Just had the semi quantitative antibody test and my number was 568. I think being older I just wanted to know what that I had at least some antibodies formed to covid.

I was vaccinated with my Moderna second shot back in February. I am immune compromised and get an infusion of IGG monthly. I had my antibodies tested last week and my number was only 31. That means I am very low, correct? I plan on getting a booster shot, my question is; should I get my booster before or after my IGG infusion?

Hi! My post vaccination antibody result is result 250 range 0.40 - 250 u/ml. Is it positive or negative?

I had Covid almost 8 months ago and did not get a
vaccination because I figured I had some natural immunity. I had the LabCorp antibody test on Monday 8/16/21 and my score is 233. I have no idea if that’s a good number or not? I’m obese
with no other known health issues I was fearful to get the vaccine because I thought it would ruin my natural immunity or increase the chance of side effects from getting the vaccine. I read that in China people only had to have a 50 in order to not have to quarantine when RE-entering their country. All the information and misinformation makes it hard for me to make a decision on whether to vaccinate or not. Thank you

My take sharing info.
Nicely explained. Few confusion raised:
(1) Too little ? body is a problem well known fact
(2)Too much antibody is a problem as this third/booster increase antibody which may PRE dispose patients to Wldenstrom’s, non Higgins type of cancer. Too much may not always fetch good outcome.
(3) third vac to immunocom: opening the Pandora’s jar.
(4) why? FDA said not to find if vaccinated has enough mature
antibody.It’s done for HepB. Fact not a fallacy though
You are voice herald the facts. Thanks

Hey there! Thanks for the post! I just had my labs drawn yesterday and back today. After having the Moderna shots in Jan and Feb of this year with a possible mild covid infection in July (a positive rapid on Sunday after being very ill but then a negative pcr on Tuesday and Wednesday- dr says shes not convinced it was a false positive but rather the shot working) and my numbers today on the antibody test came back 840 u/ml positive on antibodies. I was pleased with it being that high this far out from my shots, especially since I have been on corticosteroids for the last month and they are an immune suppressor. Without those, I am sure it would have been a little higher. It just made me feel better to know that I had a good and detectable amount of them working. Next month, I will get in line to get the booster.
I am not a medical professional but from what I am reading, levels of positive antibodies are what help you keep from getting serious covid if you do get it. So everybody get those shots and make sure you have them in you! Stay safe all!!

Hi, Claudia - Please check WHICH Covid antibody test you got. It should show TWO results: (1) the spike antibodies to the virus (which should be negative if you've never had Covid) and (2) the antibodies to the vaccine (which should be positive if you've been vaccinated and negative if you haven't). It wasn't until May or so that an actual vaccine antibody test was even developed. Before that, docs were just using the only test available, the one that determines if you had become infected. They couldn't figure out why all these vaccinated people or showing no antibodies until they figured out the font was with the diagnostic test itself.

I can't believe they are making all these vaccines and not know what number antibody levels should be at for full protection. It's the 21st Century come on already.

I had a liver transplant 8 years ago and also without a spleen… with the new liver comes my Prograf medication.
I had taken the Full course of the Pfizer Covid vaccines. A few weeks later….I had a blood test.
And my antibody results from Labcorp were negative.
A couple of months later I received another full treatment of the two Pfizer Covid vaccines… A few weeks later I again went and had another antibody test done by Labcorp.
This time, I’m happy to say that my results were positive >2500… I believe that individuals that are have a immunodeficiency and are in an older age bracket such as myself., should take responsibility and consider a booster shot as has been done in Israel and other countries. We must be proactive in our attention to this Covid plague and consider the consequences if not.

Thank you! My results just came out as 2500 U/mL, after one sinovac jab and two moderna jabs. Did you receive cross-vaccinations as well?

I have RA/Lupus so take daily immune compromising drugs and have Rituxan normally 2x a year but now once a year due to Covid. I had the Pfizer vaccine with no response so decided to try the J&J figuring I had nothing to lose. Went from .5 to 15 which my doctor says is still low but can't get any more explanation than that. So will continue to act like I am not vaccinated which is harder to do as the rest of the county is opening up. Glad I live in CT where people have taken this very seriously.

I have a naturally high igm, am on a blood thinner, my igg is a little low and iga is even lower I gtr moderna in jan-feb had a mild case of covid 9 days after second shot, does the high igm I have protect me from covid?

I did a antigen test and my results were 2.45 no vaccine yet only had covid in January 2021

Hi Jean, my husband and I both had covid last October. Went to Lab Corp and had the antibodies test. My antibodies number is 549! I do not plan on having the vaccine since obviously my natural immune response to covid was able to fight it just fine and I continue to show response to be able to fight it if need be again. I will continue to do what I can to remain healthy, workout, eat right, manage stress as best as possible. My husband elected to get the J&J shot after pressure from our doctor and has had nothing but problems since! Lots of joint pains! All this to say, if you have had covid, be cautious about running out to get the vaccine. If your body fought off the virus, you are part of the 99.8% who have survived because your immune system could handle it.

I've been immunocompromised for the last 30 years due to kidney transplants (3 of them). Other than that, I've been very healthy and not susceptible to sicknesses, and as a result, I don't bother with flu shots, nor did I get the Covid shot. I had a very, VERY mild case in January (4 days with no smell/taste, horrible if you're a coffee drinker). My antibody test came back today at 133. Given Labcorp's focus on the spike proteins only, I personally feel comfortable to assume that the myriad other identifiers within the coronavirus that my immune system recognizes gives an overall better identification of the virus' fingerprint than the vaccine alone. Obviously, each person has to make their own risk assessments and do what the feel is best. Just adding my anecdotal story since more open and transparent information is always good.

After the antibodies test my level is 3500 is that good?

Hi, I am 74 and healthy, no medications at all, 185 cm /80 kg. I got my second Pfizer shot 8,5 months before my testing and result was 557 AU/ml. My collegue is 55 and 3,5 months after second shot his test result was 8300 AU/ml. I gues mine antybodies faded in 8,5 nonths so I took 3rd shot. I found an article on Pfizer testin cca 3000 people with their vaccine and the results were: Antibody responses >21 days post second Pfizer vaccination in those not previously infected, 10 058 (6408-15 582) AU/mL, were similar to those after prior infection followed by one vaccine dose.
Pfizer and the lab where i was tested use the same test: Abbott SARS-CoV-2 IgG II Quant test

Dear Claudia Chamberlain
I work in physical virology. If your test was for antigens and it came back zero, that's normal and you should be happy because it means you haven't been infected. If you were vaccinated a few months before the antigen test, the antigens that the vaccine produces will disappear because the immune system will begin to produce antibodies. You should perform an antibody test instead of an antigen test to check the effectiveness of the vaccine.
Best wishes,
Jaime

Wouldn't it be better to have people get tested to get a baseline of Antibody numbers and then monitor whether patients get covid? How will we ever know if the vaccine/natural immunity is working without quantitative numbers?

I am not an MS patient. But came across this researching vaccine side effects. I will only tell you about my experience. Please contact your doctor to assess your risk vs benefit. I am not a doctor or employed in the medical community - just a person. This is only my experience and my opinion of my experience. You are a different person, so you are different. I am 59. I had a very nasty case of covid in Jan 2021. I had recovered in about 5-6 weeks. My symptoms were severe breathing issues, cough, headaches, muscle aches. My doctor at the time recommended that I get the shots saying - I didn't want to get it again. Failing to recognize that I had natural immunity at the time. I had my first vaccine in March of 2021 with a 3 day recovery - fever headache muscle aches, cough. I received the second vaccine in April with few side effects. By May I had started to develop an asthmatic cough. It is now October and I have severe asthma. This is new to me. Before I had allergies and very mild asthma rarely needed treatment. Meaning not even every year, but some more than others. I have also have acid reflux. I'm receiving medical care from a different doctor who understands this well. He is an immunologist. So there you go. This has been my experience and it has not been resolved. I am still suffering with severe asthma, and I would so love to go back to 2020 (does anyone actually say that?). Who knows what this all means. Do lots of research and talk to your doctor. I know that real scientific information exists - it will be hard to find though. I am of the belief that this shot is not good for everyone, however, some people can definitely benefit, and your being a little older and suffering from MS may be a big factor. I wish you peace and good luck.

i dont understand my test it says
roche anti-sars-cov-2-s Results >2500.0
0.8u/ml positive
i dont understand what this means

What I don't understand is that the vaccine was developed on the earlier strain not the delta. So isn't it the same thing whether you had covid earlier and it may not protect you from delta variant or you get the vaccine which wasn't developed to fight delta, isn't it?? I think you would still have protection either way.

Good Day
I was infected with Covid-19 back in March 2021
Did not get vaccinated yet
Wanted to get vaccinated now so I did the anti SARS - Covid test and results were over 250. U/ml
is it safe to take the vaccine now

Hi Ed, I am currently taking Tysabri as DMT for my MS. I had the 2 shots of Pfizer COVID-19 vaccines and then also the Pfizer booster. Has there been any studies or reports of how Tysabri works (or doesn't) with the Pfizer shots? Any information you may have would be appreciated. Thanks.

If you’ve acquired positive spike protein response from the vaccine. Isnt it safe to say that you’d have positive memory b and T cell response? Even for someone with low antibody numbers, isnt the important part just having the antibodies? Why are we fixated on the number. , as opposed to just having them?

Hi, I just thought I would share. I had my antibodies tested 4 times now since June 2021. June 5th 115.4 July 15th 76.6 Aug 25th 76.2 and Dec 21st 75.3 I have not had the vaccine and I do not have any symptoms. What I don't understand is why no one can tell me what this means. if .08 is the low end of having antibodies and I am one year after having Covid still testing at 75.3, It must mean something. Can some give me an honest answer? BTW, I am not Anti-Vaccine, I just don't think I need it?

Antibody tests must be done on as much of the population as possible. If this is not done, there will never be a baseline to establish immunity at any level. I got the antibody test about 30 days after having Covid and the number was 2047. I am not vaccinated.

I had covid 19 in April 2020 and had no symptoms - did a antibody test October 2021 - levels were 849. Would it be wise top take the vaccine and after taking the vaccine what effect would it have on antibody levels?

My husband and I had Covid in May 2021. Both had the pneumonia as well. We were very sick. Checked antibody levels in August, his was 1620 mine 1367. Sometime around October November we both took ill again (at different times) He had what appeared to be a very mild cold he could t shake for a couple of week and later on I got ear ache one day and the next day I had fever chills headache and extreme tiredness, all of which lasted only about 12 hours. The next day I woke up full of energy again like nothing ever happened. Because neither he nor I felt sick enough to see a dr we never got checked for Covid. It just two weeks ago we decided to check our levels again, his came back at 1746 and mine at 1676. His jumped just over 120 & mine a whopping 303. Dr says we most likely were infected a second time & did t even know it. Fast forward two days ago & my husband went to a clinic because of a funny cough. Came back positive for Covid again! He actually feels great but is just coughing. I’m not sick. How is this possible? I know our numbers are not over 2000 like others here but they’re all vaccinated and we decided to depend on our natural immunity. So far it looks like our immune system is doing what is supposed to do just dont know why we continue to get reinfected so quickly? Looking forward to hat his next antibody level I’ll show!

I'm not vaccinated and I had Covid in July 2021. I took an antibody test August 21 and my antibody level came back as 962.0 (U/mL). I decided to take another test in January 22 and despite still not being vaccinated my antibodies were up to 1518.0 (U/mL). My wife also had an increase from 16.3 to 152.0 (U/mL). I was surprised as we've been told natural immunity decreases over time but in our case it seems to have increased significantly. I'm not anti vaccine but I firmly believe if your of good health and fit that natural immunity is much better.
FQ

So is there a study that shows an estimate of what your antibody level should after being fully vaccinated be to effective, is it 2,500 is that what they want to see to be most affected against covid

I had my first symptoms of covid 12-23-2020 then in December 15, 2021 I had 111 antibodies then on 12-28-21 I had my first symptom of covid for the 2nd time. I tested multiple times with greater than 2500 on the Labcorp test. March 28th 2022 Labcorp now give an antibody number up to 25000. I test 4-7-2022 and my test result was 5670. I have no jabs.