MS News That Caught My Eye Last Week: EBV, Stem Cell Transplant, NurOwn, Progression Without Relapse

T-cells Targeting Epstein-Barr Virus at High Levels in MS Patients

The evidence of a link between the Epstein-Barr virus (EBV) and multiple sclerosis (MS) continues to mount. The current thinking is that the immune responses that fight EBV may drive the attacks against the myelin nerve coating, which is characteristic of MS. Interestingly, these researchers report that people with MS being treated with Tysabri (natalizumab), which traps T-cells in the lymph nodes, had particularly strong T-cell behavior against EBV, but not other viruses.

People with multiple sclerosis (MS) have significantly more T-cells equipped with receptors that specifically recognize the Epstein-Barr virus (EBV) than do healthy individuals, a study revealed.

Notably, no such differences were detected for T-cells with receptors specifically against other viruses.

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August 31, 2022 News by Lindsey Shapiro, PhD

Stem Cell Transplant in MS: Patients Support, but Neurologists Hesitant

Stem Cell Transplant for MS Eases Fatigue, Improves Life Quality

This is a very small study, but it adds to the growing mountain of evidence that stem cell transplants (aHSCT) can be useful for people with MS. There is no doubt in my mind, based on the interactions I’ve had with people with MS, that many would like to see this treatment more readily available. It isn’t approved for MS in the U.S., except experimentally; it’s hard to get in the U.K., and it’s very expensive in private clinics in Mexico and Russia.

As I’ve said in the past, let’s get moving on this. The National Multiple Sclerosis Society supports aHSCT for patients with very aggressive relapsing-remitting MS who have responded poorly to other disease-modifying therapies. 

Autologous hematopoietic stem cell transplant (aHSCT) — commonly called stem cell therapy — lessens fatigue and improves quality of life in people with highly active relapsing multiple sclerosis (MS), according to a small study in Lithuania.

These gains in the physical and social domains of quality of life were linked to a reduction in disability levels for up to two years after transplant in this study. That suggests that clinical improvements from aHSCT may drive boosts in life quality for MS patients.

NurOwn Found Safe, Shows Promise in Phase 2 Trial for Progressive MS

This experimental treatment removes mesenchymal stem cells (MSC) from the bone marrow of someone with MS. Those cells are then expanded and matured into cells that produce high levels of molecules that promote nerve cell growth and survival, called neurotrophic factors or NTFs. The MSC-NTFs are then injected into the patient’s spinal canal. Researchers hope the procedure will repair myelin, reduce the likelihood of further nerve cell damage, reduce neuroinflammation, and potentially slow MS progression. It sounds almost too good to be true, but let’s hope it is true.

NurOwn, a stem cell therapy being developed by BrainStorm Cell Therapeutics, showed a good safety profile among people with progressive forms of multiple sclerosis (MS) in an open-label Phase 2 clinical trial, according to new data.

The data show the experimental therapy also was associated with promising effects on patients’ walking ability, finger dexterity, cognition, and vision.

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