Columns The MS Wire - A Column by Ed Tobias Researchers Lower the Temperature to Try to Reduce MS Inflammation Researchers Lower the Temperature to Try to Reduce MS Inflammation by Ed Tobias | October 29, 2021 Share this article: Share article via email Copy article link I hate the cold. It triggers my bladder and stiffens my legs. When the leaves start to turn in Maryland, I start thinking about the warm weather in Florida. So, I was interested to read research from the University of Geneva that indicates that exposure to cold may stop, and even reverse, nerve demyelination that occurs in multiple sclerosis (MS). These scientists applied the concept of life history theory to the overactivation of the immune system in autoimmune diseases such as MS. This theory suggests that an organism normally uses its resources for growth and reproduction, but when its environment becomes hostile, those resources are diverted to saving energy and repelling the external threat. The external threat in this study was cold. MS symptoms improve in chilly mice In the study, researchers infected mice with a type of brain inflammation that mimics how MS affects the immune system. Then they put the mice into a colder than normal living environment to see how their bodies redirected resources to fight the cold. Mice generally like temperatures between 30 and 32 C (86-90 F). These mice had their environment lowered to 10 C (50 F). The researchers found that not only did the mice divert resources to help maintain their overall body heat, the heat was taken from the immune system. Once that happened, the immune system decreased its attack on the nervous system, and the MS symptoms improved. Recommended Reading October 22, 2021 Columns by Ed Tobias It’s Flu Vaccine Time Again, So Here’s What You Need to Know āThe animals did not have any difficulty in maintaining their body temperature at a normal level, but, singularly, the symptoms of locomotor impairments dramatically decreased, from not being able to walk on their hind paws to only a slight paralysis of the tail,ā study co-author Doron Merkler, a professor at the university’s pathology and immunology department, noted in a press release. The researchers believe the symptoms in the mice decreased because the cold modulated the activity of monocytes, which are white blood cells that regulate inflammation. By forcing the body to increase its metabolism to maintain body heat, the cold diverted resources away from the immune system. This led to a decrease in harmful immune cells and, therefore, a decrease in symptoms. To me, a nonscientist, this seems like the way my legs weaken in the summer heat but quickly improve when I jump into a cool swimming pool. It’s just a mouse model I’m always reluctant to put too much stock into what mice have to say. Yet this is an interesting concept, and the University of Geneva scientists hope to expand their cold research so that it can be applied in the clinic. Meanwhile, I’m getting ready to head to Florida soon, where I know I can always find a nearby swimming pool for relief of my heat-related MS symptoms. You’re invited to visit my personal blog at www.themswire.com. *** Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Multiple Sclerosis News Today or its parent company, BioNews, and are intended to spark discussion about issues pertaining to multiple sclerosis. Print This Page About the Author Ed Tobias People say to write what you know and Ed Tobias knows about MS. He's lived with the illness since 1980, when he was 32 years old. Ed's a retired, award-winning broadcast journalist and his column combines his four decades of MS experiences with news and comments about the latest in the MS community. In addition to writing his column, Ed is one of the patient moderators on the MS News Today Facebook, Twitter, and Instagram sites. Heās also the author of āThe Multiple Sclerosis Toolbox: Hints and Tips for Living with M.S.ā Ed and his wife split their time between the Washington, D.C. suburbs and Floridaās Gulf Coast, trying to follow the sun. Tags demyelination Comments Reg Bavis I have ms digonised in 95 with secondary progressive I find that the cold weather now has more of an effect than it used too my feet are cold all the time and I cannot do anything to warm them is there any way I can help this situation . Reply Ed Tobias Hi Reg, I see that others have made some suggestions and I can't do better than what they've written. I hope others will jump in with their thoughts. Ed Reply GEORGE BENTZ I was dxd with MS over 25 years ago. I have a progressive type with no relapses and can not walk with out poles. This past summer I would sit in cold water (while kayaking on the Klickitat river) for 30-45 minutes. This is very cold water that is glacier melt. I would get border line hypothermic. After I was done, the heat felt great as I need to warm up. Once I was back home, my MS symptoms seemed to lessen and these "ice bath" type of therapy was the best I have come up with. I plan to continue swimming this winter which also really helps. Reply Ed Tobias Hi George, I love swimming and using a pool to cool off but sitting in glacier melt??? No thanks. But if it works for you, go for it! Ed Reply Penny-Marie Wright I've never tried them but there are socks that use batteries to keep your feet warm. I would try ski or hunting stores as the best place to find them, I think. I can't handle either heat or cold but dressing for the cold is easier than stripping down for the heat. It'd be quite a sight if I did that, eh? Penny-Marie Reply Ed Tobias Hi Penny-Marie, I'm just the opposite. I'd rather strip down in the heat than bundle up in the cold. Ed Reply Carolyn Meehan In summer Iāve has to crawl up steps. Anything below 70F I come alive. UNM was doing a study several years ago. I have not heard the results. Maybe if there is no money, no one cares. Reply Dori Rocco Those mice must not have had spasticity! LOL! Reply Ed Tobias Hi Dori, The research reported the spasticity improved in the mice, but I do hear what you're saying. Ed Reply Melaine Compression socks make a huge difference for me. Reply Leave a comment Fill in the required fields to post. Your email address will not be published. Your Name Your Email Your Comment Post Comment
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