Interleukin-17A Plays Key Role in Inflammation in MS, Mouse Study Finds

Patricia Inacio, PhD avatar

by Patricia Inacio, PhD |

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IL-17

The immune signaling molecule interleukin-17A (IL-17A) promotes the recruiting of inflammatory cells to the central nervous system (brain and spinal cord) in a multiple sclerosis (MS) mouse model, a study found.

The findings support the potential of therapies that target IL-17 in MS. IL-17A is part of the IL-17 family of proteins.

The study ā€œInterleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1b-Producing Myeloid Cells that Promote Pathogenic T Cellsā€ was published in the journal Immunity.

Immune cells that produce the signaling IL-17 molecule, called Th17 T-cells, have been identified as key mediators of the inflammatory process in several autoimmune diseases, including psoriasis, rheumatoid arthritis, and MS.

In psoriasis, treatment with antibodies that block IL-17 is highly effective. In an early clinical trial with relapsing-remitting MS (RRMS), treatment with an antibody targeting IL-17 ā€” Cosentyx (secukinumab) ā€” yielded promising results.

However, the exact role of IL-17 in MS is still not clear.

Researchers at Trinity College Dublin investigated the role of IL-17 using a mouse model ā€” experimental autoimmune encephalomyelitis (EAE) ā€” that mimics human MS.

Results showed that EAE mice lacking IL-17 were resistant to MS. While all EAE mice developed severe symptoms 20 days after the triggering of inflammation in the brain and spinal cord (encephalomyelitis), only 35% of EAE mice without IL-17 showed clinical signs of the disease, and these were mild in severity.

Researchers found that EAE mice without IL-17 also had significantly fewer immune cells ā€” namely CD4+ and gamma delta T-cells ā€” in the spinal cord. When IL-17 was absent, the levels of IL-1-beta (another immune molecule) were lower.

Researchers looked for cells that could be producing IL-1-beta in response to IL-17. They found that IL-17A mobilized IL-1-beta-secreting immune cells (called neutrophils and inflammatory monocytes) to lymph nodes. In turn, these cells promoted the disease-promoting activity of T-cells in the CNS.

“Our team found that IL-17 plays a critical ‘priming’ role in kick-starting the disease-causing immune response that mediates the damage in EAE and MS,” Kingston Mills, a professor at Trinity’s School of Biochemistry and Immunology, and the studyā€™s lead author, said in a press release.

ā€œThe new research shows that, instead of playing a direct part in CNS pathology, a key role of IL-17 is to mobilize and activate an army of disease-causing immune cells in the lymph nodes that then migrate to the CNS to cause the nerve damage,” Mills said.

The findings support the potential of anti-IL-17 therapies in easing MS symptoms. The study also suggests that anti-IL-17 therapies do not need to cross the blood-brain-barrier ā€” a highly selective membrane that shields the CNS from the general blood circulation, and a roadblock in the efficacy of several MS therapies.

ā€œCrucially, our findings suggest that drugs that block IL-17 may not need to get across the blood-brain barrier to be effective in treating MS,” said Aoife McGinley, the studyā€™s first author.

“As well as shedding new light on the importance of IL-17 as a drugs target in RRMS, our research highlights the huge potential of drugs that block IL-17 in the treatment of other autoimmune diseases, such as psoriasis and rheumatoid arthritis” McGinley said.