July 24, 2023 News by Marisa Wexler, MS Boosting energy production in nerve fibers may help treat MS In multiple sclerosis (MS), inflammation leads to less energy production in nerve fibers by reducing the levels of enzymes in a key molecular pathway, called the TCA cycle, that cells use to generate energy, a new study shows. These findings imply that boosting activity of the TCA cycle might…
January 27, 2021 News by Marta Figueiredo, PhD Mouse Study Links Cortical Inflammation to Immune Cell Destruction Multiple sclerosis (MS)-associated inflammation in the cerebral cortex ā the outermost layer of the brain that is involved in cognitive function ā prompts the destruction of neural connections by specific immune cells, according to a study in a mouse model of MS. These immune cells targeted dendritic spines (nerve…
August 12, 2020 News by Steve Bryson, PhD Inflammation Drives Nerve Damage in Early MS, Imaging Study Shows Inflammation drives the loss of brain volume and thinning of the eye’s retina in the first five years of aĀ multiple sclerosis (MS) diagnosis, an imaging study demonstrates.Ā The findings support a therapeutic strategy of halting inflammatory activity during this initial period.Ā …
June 30, 2020 News by Patricia Inacio, PhD Boosting Cellular Energy at Sites of Myelin Loss May Stop MS Progression Loss of myelin in nerve cell fibers ā the hallmark of multiple sclerosis (MS) ā leads to a shortage ofĀ mitochondria, a cell’s powerhouse, denying these damaged fibers the energy they need to work as intended, a new study shows. Boosting the migration of mitochondria to affected nerve…
September 13, 2019 News by Joana Carvalho, PhD #ECTRIMS2019 ā Eliminating SARM1 Protects Neurons in Mouse Model of MS Eliminating SARM1, an enzyme that plays a key role in nerve cell degeneration, protects neurons in mice with experimental autoimmune encephalomyelitis (EAE), a condition that mimics the key pathological features of multiple sclerosis (MS) in humans. The preclinical findings were presented by researchers atĀ Disarm Therapeutics in a…
February 6, 2019 News by Patricia Inacio, PhD New Research About RhoE Protein Sheds Light on Two Problematic Processes in MS The RhoE protein has been identified as being important for axons’ Ā myelination and extension in the central nervous system, two processes that go awry in diseases like multiple sclerosis (MS). The findings stem from Pilar Madrigalās doctoral thesis, āRole of the small GTPase RhoE in myelination and axonal tracts development.ā…
January 28, 2019 News by Jose Marques Lopes, PhD Tiny Cell Membrane Disruptions Lead to Nerve Fiber Degeneration in MS, Mouse Study Suggests Tiny ruptures in the cell membrane of nerve fibers enable the entry of calcium and ultimately lead to their degeneration, a study in a mouse model of multiple sclerosis (MS) suggests. The study, āCalcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple…
November 8, 2018 News by Patricia Inacio, PhD Blocking Protein Called SARM1 Seen to Protect Nerve Cells from Damage Linked to MS Blocking SARM1, a protein identified as a central mediator of nerve cell degeneration, works to prevent damage to axons ā nerve cell fibers essential in cell-to-cell communication ā and may be a way of treating neurodegenerative diseases like multiple sclerosisĀ (MS), data from Disarm Therapeutics shows. Specially, genetically deleting…
September 17, 2018 Columns by Debi Wilson This Is What Excites Me About Remyelination Therapy Research RemyelinationĀ therapies are on the horizon as an innovative multiple sclerosis (MS) treatment, according to my neurologist. These therapies have been on my radar the last few years, but to hear my neurologist say they could soon be a reality makes me hopeful of the possibilities. To offer a…
November 6, 2017 News by Iqra Mumal, MSc Thin But Persistent Regrowth of Myelin Layers Sign of Health in CNS, Study Says The generation of a thin myelin sheath during remyelination ā one that continues to protect nerve cells over time ā is indicative of the long-term health and activity of the central nervous system (CNS) in demyelinating diseases such as multiple sclerosis (MS), a new study shows. These findings, which aim…
October 24, 2016 News by Patricia Inacio, PhD Study of Myelin-producing Cells a Step Forward for MS, Other Neurological Disorders A study found that the cells responsible for the production of myelinĀ selectively introduce a myelin-insulating layer in a particular set of neuronal axons in the brainās white matter. This represents a step forward in the basic mechanisms that may underlie neurological disorders, including multiple sclerosis (MS). Also, aĀ newly developed method…
December 15, 2015 News by Patricia Silva, PhD MS Nerve Degeneration Triggered by Chain Reaction in Cells Researchers in theĀ United Kingdom recently discoveredĀ that a small molecule triggers the destruction of axons, a phenomenon observed in neurodegenerative diseases likeĀ multiple sclerosis (MS). The study is titled āWallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca2+ Influx but Only Modestly Influenced by Mitochondriaā and appears inĀ the journal…
October 26, 2015 News by admin Neurons in Multiple Sclerosis Patients May be Protected by Vitamin D A new study from Sweden indicates that vitamin D could help protect nerve cellsĀ (neurons) in multiple sclerosis (MS). The report, titled “Vitamin D and axonal injury in multiple sclerosis,“ was published on October 13, 2015, in the Multiple Sclerosis Journal. Scientists have demonstrated, in…