demyelination

#ACTRIMS2018 – Clene Nanomedicine Presents Positive Results for MS Remyelinating Therapy

Clene Nanomedicine says its pre-clinical studies demonstrate the remyelination effects of CNM-Au8, supporting its potential to treat multiple sclerosis (MS) and other demyelinating disorders. Clene presented its data in a session,Ā “Nanocrystalline Gold As a Novel Remyelination Therapeutic for Multiple Sclerosis,”Ā thatĀ took place at the third annual Americas…

#MSParis2017 – MOG-associated Demyelination Can Be Treated with Steroids, but Maintenance Is Required

People with aĀ demyelinating disease associated withĀ antibodies against a myelin oligodendrocyte glycoprotein (MOG), most often develop episodes of optic neuritis (inflammation of the optic nerve) that can be treated with corticosteroids, according to data presented today at theĀ 7th Joint ECTRIMS-ACTRIMS MeetingĀ from Oct. 25-28 in Paris. MOG antibody-associated demyelination is a…

Combating Muscle Weakness Associated with MS

Sometimes walking, even with an assistance device, can be very challenging because of the extreme muscle weakness that I experience. The slow, off-balanced gait that has been my constant companion for many years prior to my 2010 multiple sclerosis (MS) diagnosis is definitely on the decline. Accepting the…

Fluorosamine Seen to Boost Remyelination in MS Mouse Model by Blocking Scarring Molecules

AĀ substance called fluorosamine was seen to boost remyelination in mice by preventing the synthesis of chondroitin sulfate proteoglycans and by promoting oligodendrocyte function. The findings showed that targeting molecules that block remyelination may be a promising therapeutic approach in multiple sclerosis (MS). Upregulation of chondroitin sulfate proteoglycans ā€” large molecules…

Severe Demyelination in Non-MS Patient After TNF-Ī± Blocker Treatment Detailed in Study

TNF-Ī± blocking drugs, such as infliximab, surprised investigators when their use in people with multiple sclerosis (MS) actuallyĀ triggered demyelination. In a case report published in the journalĀ Neuroimmunology & Neuroinflammation,Ā Vanderbilt University Medical CenterĀ researchers reviewedĀ an aggressive demyelinating event in a non-MS patient treated with TNF-Ī± blockers. TNF-Ī± blockers…

Inhibiting LINGO-1 Protein is a Potential Future Treatment for Cognitive Impairment in MS Patients

In a new study entitled ā€œLINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis miceā€, a team of scientists report that the loss of myelin in multiple sclerosis (MS) patients’ brains contributes to their cognitive impairment. They showed that inhibiting protein LINGO-1 can…