October 10, 2018 News by Jose Marques Lopes, PhD #ECTRIMS2018 – Researcher Presents Data About Myelocortical MS, a New Disease Subtype A new subtype of multiple sclerosis (MS) ā called myelocortical MS (MCMS) ā is characterized by cortical neuronal loss, but not by loss of myelin in the brain’s white matter, according to a study. Research on this new type of MS was presented today at the 34thĀ congress of…
September 12, 2018 News by Ana Pena PhD Fat Carrier Protein May Protect Nerve Cells, Help Myelin Regrow During MS, Research Suggests Apolipoprotein D (Apo D), a brain-produced carrier of fat molecules, seems to have a neuroprotective role and helps in the regrowth of myelin during multiple sclerosis (MS), a finding that may help develop new therapeutic approaches to fight the disease, new research shows.
August 22, 2018 News by Patricia Inacio, PhD Myelocortical MS, New Disease Subtype Marked by Nerve Cell But Not Myelin Loss, Identified in Study Researchers have identified a new subtype of multiple sclerosis (MS), one marked by nerve cell degeneration that occurs independently of immune system attacks against myelin, a process known as demyelination and considered a hallmark of MS. The new subtype ā called myelocortical MS ā is indistinguishable from others in the…
May 9, 2018 News by Jose Marques Lopes, PhD Subtle Myelin Damage May Occur Before Inflammatory Reactions in MS, Study Suggests Subtle changes in myelin, the protective layer of nerve fibers, may be an early event in multiple sclerosis (MS) prior to the inflammatory reaction, a new University of CalgaryĀ study shows. The study, āBiochemically altered myelin triggers autoimmune demyelination,ā was published in the journal Proceedings…
February 28, 2018 News by Patricia Inacio, PhD Inhibiting Oxidative Stress Enzyme Reduces Nerve Cell Damage in Mice with MS, Study Shows Inhibiting an oxidative stress enzyme reduced nerve cell damage and promoted the formation of new nerve cells,Ā a multiple sclerosis study in mice showed. It also helped regenerate cells that produce the nerve cell-protecting myelin sheath, researchers said. The team used a mouse model of the progressive form of MS in…
February 7, 2018 News by Iqra Mumal, MSc #ACTRIMS2018 – Clene Nanomedicine Presents Positive Results for MS Remyelinating Therapy Clene Nanomedicine says its pre-clinical studies demonstrate the remyelination effects of CNM-Au8, supporting its potential to treat multiple sclerosis (MS) and other demyelinating disorders. Clene presented its data in a session,Ā “Nanocrystalline Gold As a Novel Remyelination Therapeutic for Multiple Sclerosis,”Ā thatĀ took place at the third annual Americas…
October 27, 2017 News by Alice MelĆ£o, MSc #MSParis2017 ā Inhibiting Protein in Brain Cells Can Rejuvenate Protective Nerve Cell Coating, Study Shows Inhibiting a protein found at high levels in immune cells located in the brain can rejuvenate myelin, the protective coating around nerve cells, according to a multiple sclerosis study in mice. Blocking the protein, known as the colony-stimulating factor 1 receptor, or CSF1R, can also prevent the immune cells from…
October 25, 2017 News by Patricia Silva, PhD #MSParis2017 – MOG-associated Demyelination Can Be Treated with Steroids, but Maintenance Is Required People with aĀ demyelinating disease associated withĀ antibodies against a myelin oligodendrocyte glycoprotein (MOG), most often develop episodes of optic neuritis (inflammation of the optic nerve) that can be treated with corticosteroids, according to data presented today at theĀ 7th Joint ECTRIMS-ACTRIMS MeetingĀ from Oct. 25-28 in Paris. MOG antibody-associated demyelination is a…
October 2, 2017 Columns by Debi Wilson Combating Muscle Weakness Associated with MS Sometimes walking, even with an assistance device, can be very challenging because of the extreme muscle weakness that I experience. The slow, off-balanced gait that has been my constant companion for many years prior to my 2010 multiple sclerosis (MS) diagnosis is definitely on the decline. Accepting the…
August 29, 2017 News by Patricia Inacio, PhD Pancreas Secretes Factor That Can Rejuvenate Damaged Neuron Coating, Mouse Study Reports A substance that the pancreas secretes can promote the regeneration of the protective nerve-cell coating that is damaged in multiple sclerosis, a mouse study shows. The substance isĀ fibroblast growth factor 21, or FGF21. It promotes remyelination, the renewal of the myelin sheath protecting the central nervous system, according to the…
July 13, 2017 News by Alice MelĆ£o, MSc Dormant Herpes Virus Can Impede Repair of Myelin Sheath Whose Deterioration Causes MS, Study Reports A herpes virus that lies dormant in many people can hinder the repair of the neuron-protecting myelin sheath whose deterioration causes multiple sclerosis, a study reports. The finding about the HHV-6 virus may help explain differences in the symptoms and progression of the disease from person to person, researchers said.
May 11, 2016 News by Patricia Silva, PhD Fluorosamine Seen to Boost Remyelination in MS Mouse Model by Blocking Scarring Molecules AĀ substance called fluorosamine was seen to boost remyelination in mice by preventing the synthesis of chondroitin sulfate proteoglycans and by promoting oligodendrocyte function. The findings showed that targeting molecules that block remyelination may be a promising therapeutic approach in multiple sclerosis (MS). Upregulation of chondroitin sulfate proteoglycans ā large molecules…
April 21, 2016 News by Margarida Azevedo, MSc Mayo Clinic Neurologist, Creator of MS Lesion Tissue Bank, Receives 2016 John Dystel Prize for MS Research Dr. Claudia Lucchinetti, chair of the Department of Neurology at the Mayo Clinic and the Eugene and Marcia Applebaum Professor of Neurosciences, hasĀ received the 2016 John Dystel Prize for Multiple Sclerosis Research, an honor jointly awarded by the National Multiple Sclerosis Society and the American Academy of Neurology…
February 11, 2016 News by Patricia Silva, PhD Severe Demyelination in Non-MS Patient After TNF-Ī± Blocker Treatment Detailed in Study TNF-Ī± blocking drugs, such as infliximab, surprised investigators when their use in people with multiple sclerosis (MS) actuallyĀ triggered demyelination. In a case report published in the journalĀ Neuroimmunology & Neuroinflammation,Ā Vanderbilt University Medical CenterĀ researchers reviewedĀ an aggressive demyelinating event in a non-MS patient treated with TNF-Ī± blockers. TNF-Ī± blockers…
December 30, 2015 News by Patricia Silva, PhD NIH Grant to Advance Multiple Sclerosis Therapy Targeting Remyelination Novoron Bioscience, Inc., a biotech company focused on developing therapies for disorders of the central nervous system, recently announced that it has received a $680,000 National Institutes of Health (NIH) grant to assess the potential of a new therapeutic approach to induce remyelination in multiple sclerosis (MS). MS is…
September 22, 2015 News by Patricia Inacio, PhD Inhibiting LINGO-1 Protein is a Potential Future Treatment for Cognitive Impairment in MS Patients In a new study entitled āLINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis miceā, a team of scientists report that the loss of myelin in multiple sclerosis (MS) patients’ brains contributes to their cognitive impairment. They showed that inhibiting protein LINGO-1 can…