Immune cells, believed to drive autoimmunity, are selectively increased in the gut of patients with multiple sclerosis (MS), along with lower numbers of cells controlling inflammation, suggesting that immune processes in the gut impact MS disease mechanisms. The study, “The role of gut immunity in multiple sclerosis patients,”…

As inflammation and neuronal death progressed in the brains of mice with multiple sclerosis (MS), a molecular signaling pathway with a key player called Wnt was seen to come into action in brain areas crucial for memory production, triggering the formation of new neurons. The findings, presented in the study…

A link indeed appears to exist between multiple sclerosis (MS) and unusual changes in the bacterial composition of the gut, according to researchers at Brigham and Women’s Hospital (BWH). In their study, “Alterations of the human gut microbiome in multiple sclerosis,” published in the journal Nature Communications,…

Inflammation in a brain region called the hippocampus might explain why patients with multiple sclerosis (MS) suffer from depression far more often than patients with other chronic brain diseases. The findings, described in the report “Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis,” published in the…

Researchers at the University of Technology Sydney (UTS) ithree institute are taking a novel approach in an attempt to halt disease progression in multiple sclerosis (MS). The scientists are planning to explore the anti-inflammatory potential of a controlled infection by parasitic worms as a way of preventing the harmful over-inflammation observed in MS and…

Children and adolescents with multiple sclerosis (MS) differ from others in the composition of their gut flora, with higher levels of inflammation-causing bacteria and lower levels of anti-inflammatory bacteria, according to a study from  the University of British Columbia, Canada. The findings, supporting previous hypotheses that the composition of the gut microbial community could influence the development…

Dietary habits and the composition of the gut flora can influence neuroinflammation and affect the outcome of neurodegenerative diseases such as multiple sclerosis (MS), according to a study published in the journal Nature Medicine and titled “Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous…

Researchers at the School of Medicine of the University of California (UC), Riverside, found that TNF-alpha, a factor known for its pro-inflammatory actions, also triggers processes that end inflammation by inducing a type of immune surveillance cell, called M-cells. By advancing our understanding of immune processes, the finding may lead to…

New research from Argentina explores the idea that controlling symptoms of type 2 diabetes (metabolic syndrome) can also beneficially impact multiple sclerosis (MS) disease progression. The study,“Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis,“ appeared March 7 in the journal…

Professor Steve Wilton and Dr. Rakesh Veedu from Murdoch University’s Centre for Comparative Genomics in Western Australia received project grants of $50,000 and $25,000, respectively, to investigate and develop new methods for the treatment of multiple sclerosis (MS). The grants are part of $1.834 million in research funding given by MS…

In a new study, researchers from the University of Toronto, Canada, uncovered the process behind the formation and maintenance of tertiary lymphoid tissues (TLTs), structures found in the meninges in the brains of multiple sclerosis (MS) patients. Their findings, reported in the article “Integration of Th17- and Lymphotoxin-Derived Signals Initiates…

Researchers are proposing for a first time that multiple sclerosis (MS) is triggered by the death of a specific cell population within the central nervous system called oligodendrocytes. The study, titled “Oligodendrocyte death results in immune-mediated CNS demyelination,” was published in the journal Nature Neuroscience. Oligodendrocytes,…

Brickell Biotech, Inc., a pharmaceutical company developing novel therapies in the field of dermatology, recently announced it has exclusive worldwide rights over a series of new, retinoic acid-related orphan nuclear receptor gamma (RORy) inhibitors from the New York University (NYU) and Orca Pharmaceuticals. As part of the agreement, Brickell will be…

RedHill Biopharma, Ltd., recently announced the conclusion of the last dosing and patient follow-up visit for its Phase 2a proof-of-concept study to assess the efficacy and safety of the experimental drug RHB-104 as an add-on therapy to interferon beta-1a in patients with relapsing-remitting multiple sclerosis (RRMS).

The National Multiple Sclerosis Society awarded a $700,000 research grant to Dr. Bonnie Dittel, a senior investigator at the BloodCenter of Wisconsin (BCW) and adjunct professor at the Medical College of Wisconsin. The grant will help Dr. Dittel advance her research into how specific immune cells in the body can…

In a new study entitled “Reduced cortical microvascular oxygenation in multiple sclerosis: a blinded, case-controlled study using a novel quantitative near-infrared spectroscopy method,” a team of researchers at the Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary investigated whether frequency domain near-infrared spectroscopy technology can measure the potential…

A recent study published in the journal Science Translational Medicine provided new insights into the role of B cells in multiple sclerosis (MS), and points to a specific line of possible new therapies. The study is entitled “Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell…

A new study from Sweden indicates that vitamin D could help protect nerve cells (neurons) in multiple sclerosis (MS). The report, titled “Vitamin D and axonal injury in multiple sclerosis,“ was published on October 13, 2015, in the Multiple Sclerosis Journal. Scientists have demonstrated, in…

A recent study of people with relapsing remitting multiple sclerosis (RRMS) found that high-dose oral vitamin D3 supplementation did not influence markers of inflammation. Inflammation is a reaction to bodily injury that may be over-activated in people with multiple sclerosis (MS). The article, titled “Vitamin D supplementation and systemic inflammation in…

Recent attention to the role of mitochondria in the etiology of multiple sclerosis (what causes the disease) suggests that mitochondrial defects and mitochondrial structural and functional changes may contribute to the disease. Researchers studying mitochondria in multiple sclerosis believe abnormalities in mitochondrial dynamics impact cellular pathways such as inflammation and…

Researchers at Monash University and the MIMR-PHI Institute of Medical Research in Australia recently proposed that specific human stem cells with immunomodulatory properties represent a new promising therapeutic strategy for diseases like multiple sclerosis (MS). The study was published in the Journal of Neuroinflammation and…

Researchers in the Department of Immunology at St. Jude Children’s Research Hospital in Memphis were able to identify a faulty “brake” in immune cells which may be involved in the inflammation triggering multiple sclerosis (MS). This brake is believed to be able to control inflammation, offering the potential for the development of new…

Researchers at the Walter and Eliza Hall Institute, the oldest research center in Australia, developed a molecule that may quell inflammation and stop the progression of multiple sclerosis (MS). The molecule could eventually be used as a drug for the disease. MS is an inflammatory autoimmune disease in which the body attacks…

A team of researchers from Italy recently examined if p53 genetic variants influence synaptic and toxic effects of cytokines in the neurodegenerative processes that occurs in Multiple Sclerosis. The study, entitled “Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53,” was recently published…