October 7, 2021 News by Steve Bryson, PhD 1 Year of Ocrevus Not Linked to Higher Risk of Brain Infection PML One year of Ocrevus (ocrelizumab) treatment does not increase the risk for a rare brain infection ā called progressive multifocal leukoencephalopathy (PML) ā in people with multiple sclerosis (MS), a study suggests. The study, āRisk Assessment of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patients during…
April 15, 2021 News by Steve Bryson, PhD Ocrevus Use Linked to PML in Man, 78, With PPMS, Case Report Says A 78-year-old man withĀ multiple sclerosis (MS) developed the brain infection progressive multifocal leukoencephalopathy (PML) after two years of treatment with Ocrevus (ocrelizumab), a recent case report detailed. Treatment was discontinued and, as the patient’s symptoms worsened, he was moved to off-label…
January 16, 2020 Columns by Tamara Sellman Need to Know: Blood Tests and Multiple Sclerosis Editor’s note: “Need to Knowā is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum. This week’s question is inspired by the post “Is It a Multiple Sclerosis Diagnosis or Something Else?” from July 20, 2018.
September 19, 2019 Columns by Tamara Sellman Need to Know: What Is the JC Virus? Editor’s note: “Need to Knowā is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum. This week’s question is inspired by the forum topicĀ “Does PML worry you?” from April 18. The world of multiple sclerosis (MS)…
May 16, 2018 News by Janet Stewart, MSc Complications from Gilenya Treatment Managed Successfully, Case Report Says A case study reported the successful management of a multiple sclerosis (MS) patient who developed a rare condition in the brain ā progressive multifocal leukoencephalopathyĀ (PML) ā due to treatment with Novartis Pharmaceuticalās Gilenya (fingolimod). The study, titled āFingolimod-associated PML with mild IRIS in MS: A…
April 27, 2018 News by Patricia Inacio, PhD #AAN2018 – Extending Time Between Tysabri Doses Linked to Lower PML Risk, Analysis Suggests Extending the time between standard doses ofĀ TysabriĀ (natalizumab)Ā from four weeks to up to 12 weeks is linked to a significant decrease in the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients infected with what’s known as the JC virus, according to a recent analysis of data from…
February 5, 2018 News by Patricia Inacio, PhD #ACTRIMS2018 ā Extending Tysabri Treatment Intervals May Reduce PML Risk, TOUCH Registry Data Suggest Extending the dosing periods of Tysabri (natalizumab) treatment may help reduce the risk of progressive multifocal leukoencephalopathy, or PML, in multiple sclerosis (MS) patients infected with the JC virus, a study suggests. The study, āNatalizumab Extended Interval Dosing Is Associated with a Reduction in Progressive Multifocal Leukoencephalopathy…
November 16, 2017 Columns by Laura Kolaczkowski A JC Virus Primer There is often alarm and confusion about the JC virus, how we get it, and what it means to people with multiple sclerosis. This is my quick primer to help address these questions in a very basic way. What is the JC virus? The first person identified with this…
August 31, 2017 News by Alice MelĆ£o, MSc Tecfidera Shows Promise as Replacement MS Therapy for Tysabri, Study Shows Tecfidera (dimethyl fumarate) can be a suitable replacement therapy whenĀ Tysabri (natalizumab) is discontinued, keeping low levels of disease activity in patients with relapsing-remitting multiple sclerosis (RRMS), according to a report published in theĀ Journal of Neurology, Neurosurgery & Psychiatry. Several studies have demonstrated the effectiveness and…
May 25, 2017 News by Patricia Silva, PhD PML Found in Ocrevus-Treated Patient Who Had Used Tysabri for 3 Previous Years A multiple sclerosis (MS) patient treated in Germany withĀ Ocrevus (ocrelizumab)Ā has developed the dreaded brain infection progressive multifocal leukoencephalopathy (PML).Ā But it is not clear whether the recently approvedĀ Genentech/Roche-developed treatmentĀ is the cause. The patient took the last dose of a three-year course of Tysabri (natalizumab)Ā in February. Tysabri is…
January 29, 2016 News by Patricia Silva, PhD Guidelines Issued for Monitoring of MS Patients on Natalizumab Treatment A panel of neurologists from the U.K. and Ireland recently developed practical consensus guidelines for monitoring multiple sclerosis (MS) patients on natalizumab (Tysabri)Ā therapy for the risk of developing progressive multifocal leukoencephalopathy (PML), a life-threatening viral infection caused by the John Cunningham (JC) virus. The panel was summoned by…
September 25, 2015 News by Patricia Silva, PhD Possible JC Virus Vaccination Offers Important Implications for MS Treatment Two studies recently published in the journal Science Translational Medicine, revealed a possible new vaccine treatment for JC virus with important implications for multiple sclerosis (MS) treatment. The studies are entitled āJC polyomavirus mutants escape antibody-mediated neutralizationā and āBroadly neutralizing human…