Mitochondrial abnormalities, or problems in the powerhouses of cells, seem to be a main contributor to the death of important nerve cells in the cerebellum — a brain region involved in motor control — in people with multiple sclerosis (MS), a new study suggests. Researchers found that inflammation and…
motor function
An experimental medicine, 2-D08, boosts motor function in mice and primate models of multiple sclerosis (MS) by repairing the myelin sheath, the protective coating on nerve fibers that’s damaged in people with the neurodegenerative condition, a study showed. 2-D08 also outperformed the approved therapy dalfampridine, sold as Ampyra…
Coupling a noninvasive brain stimulation procedure with an intensive rehabilitation program significantly improved motor function and balance in adults with relapsing-remitting multiple sclerosis (RRMS), a randomized clinical trial finds. High-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive treatment approach that delivers pulses of magnetic fields to modulate nerve…
Delivering an antibody against the Nogo-A protein to a specific region of the nose called the olfactory mucosa improved motor function and preserved myelin in the spinal cord of a mouse model of multiple sclerosis (MS), according to a recent study. This intranasal mode of delivery enabled significant concentrations…
Tecfidera (dimethyl fumarate) appears to have similar benefits to Gilenya (fingolimod) in preventing relapses and the loss of motor function and cognition in people with multiple sclerosis (MS), a study with real-world data found. The two medications also led to similar findings on MRI scans, including in…
Four weeks of robotic exoskeleton-assisted exercise rehabilitation, called REAER, worked better than conventional gait training in improving mobility and cognitive function in multiple sclerosis (MS) patients with substantial walking difficulties, according to a small trial. A robotic exoskeleton consists of an externally worn device that encases a user’s hips, back,…
Oral administration of N-acetylglucosamine (GlcNAc) — a natural simple sugar sold as a dietary supplement — prevents myelin degeneration and loss of motor function in a mouse model of multiple sclerosis (MS). Myelin, the protective sheath around nerve fibers that helps to speed transmission of signals between nerve cells, is damaged…
People whose advanced progressive multiple sclerosis (MS) limits their mobility can strengthen their lower limbs and improve life quality by engaging in regular standing exercises in their homes, a U.K. study into physiotherapy programs for this patient group reports. The study, “Assessment…
Naboso Technology has expanded its product offerings with new insoles and training mats specifically designed to stimulate the nervous system through the skin on the bottom of the feet. The products were developed to help improve balance, posture, movement and restore motor function, as part of a neurorehabilitation strategy…
Difficulties with walking and balance are common among people with multiple sclerosis and strongly affect their quality of life — even when disease progression may not be evident on scans or other measures of MS advance, according to research presented at a meeting last fall and recently reviewed by the National…
A deterioration in multiple sclerosis patients' handwriting aligns with drops in their movement, sensory and cognitive skills, a study reports. MS includes loss of hand dexterity and finger movement control. This affects a patient's capacity to manipulate objects and coordinate hand movement, skills needed in handwriting. Previous studies have shown that MS patients had less handwriting rhythm and control than healthy people. This time researchers decided to compare the handwriting movements of both MS patients and healthy volunteers. The research involved 19 MS patients and 22 healthy age-matched controls. The team asked participants to write a specific sentence on a digitizing tablet. They discovered that the way MS patients wrote was much different than those of the controls. The patients took a lot longer to write each word and to achieve spacing between words. This led to them taking a much longer time overall to write a sentence than healthy people. In addition, analysis of handwriting strokes showed that MS patients' writing wasn't as smooth as that of healthy people. Researchers also found a correlation between patients’ movement abilities and cognitive status on the one hand and their handwriting ability on the other. The team said it believed “these findings might be very useful when planning rehabilitative task-oriented interventions focused on handwriting abilities.” In fact, rehabilitation specialists should consider evaluating “both the motor movement and the cognitive status of PwMS [patients with MS] in order to tailor the intervention."
Kinesiology professor Richard van Emmerik and his colleagues at the University of Massachusetts Amherst recently received a two-year $833,000 grant from the U.S. Department of Defense to create an improved diagnostic test for multiple sclerosis (MS). The scientists expects their research to help an estimated 2.3 million people worldwide who live with…
Riding and other activities with horses can help adults and children with the balance, gait, and psychomotor disorders that are hallmarks of multiple sclerosis, according to review of 16 studies. The review, “Therapeutic Effects of Horseback Riding Interventions: A Systematic Review and Meta-analysis,” was published in the …
A modified Paleolithic diet reduced fatigue and increased the quality of life of patients with relapsing-remitting multiple sclerosis (RRMS), a study shows. The diet may also reduce inflammation by increasing vitamin K levels, the researchers said. The study, “Randomized control trial evaluation of a modified Paleolithic dietary…
Robot-assisted training may be an effective therapy to improve motor function in the lower limbs of patients with multiple sclerosis (MS), and help in rehabilitation, according to the study “Robot-Guided Rehabilitation Improves Sensorimotor Functions in Lower-Limb Impairments of Individuals with Multiple Sclerosis,” presented at the Consortium of Multiple Sclerosis Centers…
Difficulties with cognitive function and fatigue are the main reasons patients with multiple sclerosis (MS) struggle to stay gainfully employed, a new study published in the December edition of the International Journal of MS Care has found. The study is titled “Factors Associated with Employment Status in Individuals with…