August 1, 2022 News by Vanda Pinto, PhD Higher, Possibly Damaging, Zinc Levels Seen in Blood of MS Patients People with multiple sclerosis (MS) have significantly higher and potentially damaging blood levels of zinc and a greater activity of the superoxide dismutase (SOD) enzyme than is evident in people without MS or similar diseases, a study reported. SOD is an enzyme that requires zinc to function properly, including…
April 6, 2021 News by Marisa Wexler, MS N-acetyl Cysteine Safe, But Failed to Lessen MS Fatigue Treatment with the antioxidant Nāacetyl cysteine is well-tolerated, but failed to outperform a placebo at easing fatigue in people with progressive multiple sclerosis (MS), a small clinical trial found. More studies now are needed to determine if oxidative stress contributes to fatigue or clinical progression in MS patients, and…
September 2, 2020 News by Steve Bryson, PhD Altered Gut Microbiome, Metabolism Found in Japanese RRMS, SPMS Patients, Study Reveals Alterations in gut bacteria and bacterial metabolism were found in Japanese people at different stages of multiple sclerosis (MS) compared to healthy controls, a study reports. Reduced fatty acid synthesis in gut bacteria found in those with relapsing-remitting MS (RRMS)…
April 16, 2020 News by Joana Carvalho, PhD Scientists Build Map of Toxic Immune Cells Contributing to Neurodegeneration in MS Scientists have built a map of the toxic immune cells that contribute to neurodegeneration in multiple sclerosis (MS).Ā Their findings may open the door to the development of new medications that protect the brain from the effects brought on by these harmful immune cells. Results were reported in the study,…
March 4, 2020 News by Patricia Inacio, PhD Natural Molecule NAC May Help Improve MS Brain Function, Study Reports Treatment for two months with N-acetylcysteine, or NAC ā a natural molecule that enhances the levels of antioxidants ā significantly improved metabolic activity in certain brain regions among people with multiple sclerosis (MS), a small clinical study reports. This increase in metabolic activity was accompanied by improvements…
May 31, 2019 News by Jose Marques Lopes, PhD Abnormal Activation of Neutrophils a Potential Therapeutic Target in MS, Mouse Study Suggests Targeting the excessive activation of immune cells called neutrophils, and the associated oxidative stress, may be a therapeutic strategy in patients with multiple sclerosis (MS), according to a mouse study. TheĀ study, āDeficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production,ā was…
December 11, 2018 News by Alice MelĆ£o, MSc WUSTL Team Receives $6.3 Million Grant to Develop PET Scan Tracers The Washington University School of Medicine in St. LouisĀ (WUSTL) will create a new research center to investigate and advance the development of tracers for positron emission tomography (PET) scans. The center, which will be established at WUSTLās Mallinckrodt Institute of Radiology (MIR), is going to focus on the…
June 6, 2018 News by Patricia Inacio, PhD #CMSC2018 ā Inhibiting Oxidative Stress Enzyme Promotes Resealing of Blood-Brain Barrier in MS Mouse Model Inhibiting an oxidative stress enzyme called myeloperoxidase protects the blood-brain barrier in a mouse model of multiple sclerosis (MS), limiting the migration of immune cells and halting their attack on nerve cells, researchers have found. Disruption of the blood-brain barrier is a hallmark of various disorders, including MS, and when…
February 28, 2018 News by Patricia Inacio, PhD Inhibiting Oxidative Stress Enzyme Reduces Nerve Cell Damage in Mice with MS, Study Shows Inhibiting an oxidative stress enzyme reduced nerve cell damage and promoted the formation of new nerve cells,Ā a multiple sclerosis study in mice showed. It also helped regenerate cells that produce the nerve cell-protecting myelin sheath, researchers said. The team used a mouse model of the progressive form of MS in…
August 18, 2017 News by Patricia Silva, PhD GeneFo and MitoQ Plan Webinar on How Mitochondrial Antioxidants May Impact MS The online multiple sclerosis community GeneFoĀ will hold a webinar next week to discuss the latest research findings on how mitochondrial antioxidants may affect MS. The webinar, which will be open to patients who register, will start at 1 p.m. U.S. Eastern Standard Time on Thursday, Aug. 24. GeneFo…
January 17, 2017 News by Ćzge Ćzkaya, PhD Tecfidera Seen to Potentially Limit Vision Problems in MS Genetically silencing the transcription factor Nrf2 in a mouse model of multiple sclerosis (MS) results in visual deficits, inflammation of the optic nerve, and degeneration of the retinal ganglion cells (RGC), according to a study published in the scientific journal Molecular Vision.
July 13, 2016 News by Patricia Inacio, PhD Steroid Use Lowers Oxidative Stress in Cerebrospinal Fluid of Progressive MS Patients in Pilot Study AĀ pilot study inĀ patients with progressive multiple sclerosis (MS) found a steroid treatmentĀ of benefit by decreasingĀ oxidative stressĀ in theĀ cerebrospinal fluid. The study, āOne-time intrathecal triamcinolone acetonide application alters the redox potential in cerebrospinal fluid of progressive multiple sclerosis patients: a pilot study,ā was published in the journalĀ …
November 30, 2015 News by Patricia Inacio, PhD Pomegranate Seed Oil May Be Therapy for MS Disease and Its Progression In a recent study,Ā researchers show how a natural antioxidant within pomegranate seeds is capable of inhibiting demyelination in a mouse model for multiple sclerosis (MS), supporting novel formulations of natural antioxidants as therapeutics for demyelinating diseases. The study,Ā āTreatment of a multiple sclerosis animal model by a novelĀ nano dropĀ formulation of…