News

Using a new approach, researchers have identified new signaling molecules that regulate the activation of certain subsets of astrocytes thought to drive inflammation in multiple sclerosis (MS). The new methodology, called FIND-seq, enables the selection of single cells from a sample based on the expression of specific genes and…

Pheno Therapeutics has entered into an agreement with UCB to develop new therapies aimed at remyelination to treat multiple sclerosis (MS) and other neurological disorders that are characterized by the loss of myelin, the companies announced. “This license allows us to accelerate a promising drug target towards…

A new therapy that delivers an anti-inflammatory compound to nervous system immune cells via cellular “shipping containers” called exosomes showed promise in a mouse model of multiple sclerosis (MS), a study reports. The study, “Resveratrol-loaded macrophage exosomes alleviate multiple sclerosis through targeting microglia,” was published in the…

Aerobic training for up to three months significantly outperformed less-strenuous exercise at improving walking capacity among people with multiple sclerosis (MS), a new study reports. However, the benefits of aerobic exercise seem to be greater among patients without MS-related damage in the insula — a brain region involved in…

Quanterix Corporation‘s laboratory test designed to measure blood levels of neurofilament light chain (NfL) has been validated by the Clinical Laboratory Improvement Amendments (CLIA), an arm of the U.S. Food and Drug Administration (FDA) that regulates laboratory testing. The company now is planning to launch its laboratory developed test,…

A treatment containing neural stem cells derived from a human fetus was shown to be well tolerated in a small clinical trial of people with progressive forms of multiple sclerosis (MS). Results showed some promising effects on markers of inflammation and brain atrophy. Researchers said these preliminary findings “warrant…

The wing of the small aircraft dipped below the horizon, revealing a strip of sand in the middle of the Bering Sea. On one side, miles of ocean. On the other, a lagoon. It was 1995, and Melissa Cook, her husband Elgin, and their three small children were beginning an…

A protein in the virus that causes COVID-19 is structurally similar to several proteins targeted by the immune system in multiple sclerosis (MS), a new study shows. The results provide a potential mechanism for how COVID-19 could trigger MS-like disease in susceptible individuals, researchers said. The study, “…

A behavioral intervention that teaches people with multiple sclerosis (MS) strategies for becoming physically active significantly improved patient-reported measures of fatigue over a year, but had no effect on other self-reported disease measures, according to new data from a Phase 3 trial. Earlier results had shown that the approach,…

Helius Medical Technologies has extended by six months a program that allows multiple sclerosis (MS) patients in the U.S. to access its Portable Neuromodulation Stimulator (PoNS) device at a reduced cost. The Patient Therapy Access Program (PTAP) partly subsidizes the cost of using PoNS — an…

The amounts of more than 60 species of bacteria are altered in the gut in people with multiple sclerosis (MS) compared with those without the disease, a new study reports. Researchers also identified differences in the makeup of viruses that infect gut bacteria in patients, which they said may…

Multiple tiny injections of myelin-related small proteins alongside suppressors of the activity of dendritic cells, done using a device akin to a tattoo gun, powerfully reduced the severity of multiple sclerosis (MS) in a mouse model of the disease. That’s according to new findings announced by Therapeutic Solutions…

TeraImmune is extending its collaboration with the National Institute of Allergy and Infectious Diseases (NIAID) to continue developing regulatory T-cell-based therapies for multiple sclerosis (MS) and other autoimmune diseases. The extension will let the company continue optimize the manufacturing process for its lead regulatory T-cell (Treg) product in…

Women with chronic health conditions like multiple sclerosis (MS) often experience disbelief and disenfranchisement from healthcare providers when they seek care, a new study highlights. The study, “Women’s Experiences of Health-Related Communicative Disenfranchisement,” was published in Health Communication. There is a long history of discrimination and…

People with multiple sclerosis (MS) in the U.S. now may order a Portable Neuromodulation Stimulator (PoNS) device online through a new e-commerce site launched by the device’s developer, Helius Medical Technologies. The website, built in partnership with the telehealth company UpScript, marks the first time…

Researchers in Iran are conducting a clinical trial to test the effects of taking ginger supplements for people with relapsing-remitting multiple sclerosis (RRMS). Ginger extracts have shown some promise in animal models of multiple sclerosis (MS), but no trial has yet determined the impact that ginger supplements may…

A second person with non-active secondary progressive multiple sclerosis (SPMS) treated with foralumab nasal spray in a single-patient access program is continuing to show improvements 11 months after starting the therapy, according to an update from foralumab’s developer, Tiziana Life Sciences. The patient, dubbed EA2, experienced a…

The risk of developing multiple sclerosis (MS) doesn’t seem to be influenced by consuming alcohol, according to a large-scale analysis in the U.K. After adjusting for known MS risk factors, including smoking, childhood obesity, socioeconomic status, or genetics, the findings remained the same. The analysis was published in Nature…

The U.S. Food and Drug Administration (FDA) has cleared AB Science to initiate a Phase 3 clinical trial of its investigational treatment masitinib in people with progressive forms of multiple sclerosis (MS). The decision follows approvals in several European countries that will also host trial sites, including…

Multiple Sclerosis News Today brought consistent coverage of the latest scientific research, developments in treatment, and clinical trials for multiple sclerosis (MS) throughout 2022. This is a list of the top 10 most-read articles we published this past year, with a brief description of each. We look forward…

The U.S. Food and Drug Administration has approved TG Therapeutics‘ B-cell-depleting therapy ublituximab under the brand name Briumvi for the treatment of adults with relapsing forms of multiple sclerosis (MS), the company announced. The approval covers clinically isolated syndrome, relapsing-remitting MS (RRMS), and active secondary progressive…

Daily use of MS14, a natural product derived from Persian medicine, safely led to gains in physical activity and walking for people with multiple sclerosis (MS) with walking difficulties, according to data from a small placebo-controlled trial. MS14, which contains both herbal and marine ingredients, “could be used as…

About half of all individuals diagnosed with multiple sclerosis (MS) have at least one other co-occurring medical disorder, and such comorbidities add a significant economic burden for MS patients in managing their condition, according to an Italian study. These added costs result from an increase in the use of…

The European Investment Bank has entered a financial agreement with Numares Health to support further development of a fully automated platform to improve the diagnosis of chronic diseases such as multiple sclerosis (MS). The loan of up to €20 million (about $21 million) is expected to advance the…

A stem cell transplant more effectively slowed disability worsening in people with active secondary progressive multiple sclerosis (SPMS) than anti-inflammatory treatments and disease-modifying therapies (DMTs), a study has found. More transplant recipients also experienced clinical improvements that were sustained after three and five years. After 10 years,…

Severing the lower part of the vagus nerve — one of the main neurological pathways that connects the brain to the gut — led to less myelin loss in a mouse model that’s commonly used to study multiple sclerosis (MS). The findings suggest that the vagus nerve plays…

About one in five people with multiple sclerosis (MS) may be unfit to drive a vehicle due to disease-related difficulties, according to a review of published studies. Cognitive and visual difficulties were most frequently associated with impaired driving ability, both on the road and in a simulation. However, the…

Ocrevus (ocrelizumab) was equally effective in reducing disease activity after two years in people with primary progressive multiple sclerosis (PPMS) and relapsing-remitting multiple sclerosis (RRMS), a new study reports. The therapy also slowed disease progression in both groups, although a stronger effect was seen with RRMS patients…

Myelin, the fatty-rich material surrounding nerve fibers that’s progressively damaged in multiple sclerosis (MS), provides metabolic support to a type of nerve cell in the brain that controls the activity of other nerve cells, a study discovered. Researchers showed mitochondria, the cell’s energy producers, are specifically clustered in…

Frequency Therapeutics has established a clinical advisory board, with experts across neuroscience fields, to help guide its small molecule treatment candidate for remyelination in multiple sclerosis (MS) into clinical testing. The company is planning to initiate a first trial of the molecule, designed to boost remyelination — the…