August 22, 2022 News by Marta Figueiredo, PhD MS Spasticity Therapy Baclofen Helps to Repair Myelin: Early Study Baclofen, an approved therapy for spasticity in multiple sclerosis (MS) patients, promoted the repair of myelin ā the protective sheath around nerve fibers that’s progressively lost in MS ā in a mouse model of the disease, a study showed. These findings suggest baclofen ā sold as oral tablets,…
June 14, 2021 News by Steve Bryson, PhD Scientists Discover Enzyme Needed for Activating Myelin Repair The enzyme TET1, which is progressively lost with age, is essential to activate genes needed to repair myelin ā the sheath around nerve cells that is damaged in people with multiple sclerosis (MS) ā a study in mice has found. The…
February 23, 2021 News by Diana Campelo Delgado Johns Hopkins Neuroscientist Wins 2020 Barancik Prize for Innovation The 2020 Barancik Prize for Innovation in MS Research has been awarded to neuroscientistĀ Dwight E. Bergles, PhD, a Johns Hopkins University professor,Ā for his work in understanding the function of brain cells in multiple sclerosis (MS). This international prize awards $100,000 to the recipient. Administered by the National MS…
February 28, 2020 News by Ana Pena PhD #ACTRIMS2020 – Remyelination in Adult Animal Brains Possible via Cell Transplant, Study Says Transplanting humanĀ glial progenitor cells (GPCs) ā brain cells able to generate myelin-producing cells ā effectively led to remyelination in the brains of adult mice with myelin disorders, a study found. These results were presented atĀ the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2020, running…
October 14, 2019 News by Marisa Wexler, MS Metformin Works to Promote Remyelination in Ways Similar to Fasting, Study Says Metformin, a common diabetes treatment that works to mimic dietary fasting, was seen to promote remyelination in the stem cells of elderly rats, suggesting it may be useful in treating multiple sclerosis. “Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells” was published in…
December 4, 2018 News by Patricia Inacio, PhD Small Molecule Linked to Cells That Control Myelin Production and Repair in Study The formation of new myelin sheaths by oligodendrocytes is impaired in the absence of a small molecule, called Vav3, that oversees pathways regulating the shape of oligodendrocytes, new study reports. Its researchers pinpoint Vav3 as a potential therapeutic target to improve and speed myelin repair in diseases like multiple sclerosis…
November 29, 2018 News by Patricia Inacio, PhD Adult Oligodendrocytes May Replenish Myelin Production in MS, Study Suggests Mature, adult oligodendrocytes can reacquire their ability to produce myelin to replace the ones lost in diseases like multiple sclerosis (MS) without undergoing a stem cell-like state, a new study shows. Myelin is the fat-rich substance that wraps around nerve fiber projections (axons) protecting them and increasing the speed of…
September 24, 2018 News by Jose Marques Lopes, PhD Oligodendrocytes, Cells That Produce Myelin, Can Be Generated from Astrocytes, Study Reports A molecule known as Sox10 enables brain cells called astrocytes to convert into myelin-forming oligodendrocytes, a new study in mice reports. The findings suggest an approach for myelin repair in patients with multiple sclerosis (MS) and similar disorders, its researchers said. The study, āIn vivoĀ conversion of…
July 19, 2018 News by Jose Marques Lopes, PhD Blocking Protein Receptor Called M3R Seen to Promote Remyelination in Mice Model, Study Reports Blocking a protein receptor called muscarinic type 3 (M3R) could be an effective way to promote remyelination in multiple sclerosis (MS) patients, according to aĀ State University of New York at Buffalo (UB) study in mice. The research, āMuscarinic receptor M3R signaling prevents efficient remyelination by…
July 13, 2017 News by Alice MelĆ£o, MSc Dormant Herpes Virus Can Impede Repair of Myelin Sheath Whose Deterioration Causes MS, Study Reports A herpes virus that lies dormant in many people can hinder the repair of the neuron-protecting myelin sheath whose deterioration causes multiple sclerosis, a study reports. The finding about the HHV-6 virus may help explain differences in the symptoms and progression of the disease from person to person, researchers said.
February 4, 2016 News by Margarida Azevedo, MSc Experimental MS Therapy Seen to Promote Myelin Regeneration in Preclinical Study RegeneRx Biopharmaceuticals, Inc.,Ā announced the publication of a research article detailing the process by whichĀ Thymosin beta 4 (TĪ²4), the company’s novel therapeutic peptide, effectively promoted the remyelination process in two separate animal models commonly used for multiple sclerosis (MS) research. The article, āThymosin beta4 promotes oligodendrogenesis in the demyelinating…
January 28, 2016 News by Patricia Silva, PhD MS Researchers ID Protein That Works to Block Nervous System Remyelination A study from the University of Cambridge showed that the membrane-bound signaling protein EphrinB3, which acts by inhibiting the maturation of oligodendrocytes, also blocks the remyelination of damaged neurons in multiple sclerosis (MS). The study,Ā “Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS re-myelination,“Ā uncovered a new target toĀ explore…