March 31, 2021 News by Marisa Wexler, MS Machine Learning of Walking Patterns Could Help Predict MS Progression A machine learning-based method that examines walking abnormalities in people with multiple sclerosis (MS) could help identify patients who are at high risk of worsening symptoms, a study suggests. The study, “Predicting Multiple Sclerosis from Gait Dynamics Using an Instrumented Treadmill – A Machine Learning Approach,”…
March 29, 2021 News by Marisa Wexler, MS PoNS Device to Help Adults in Rehab for Walking Problems Gets FDA Approval The U.S. Food and Drug Administration (FDA) has authorized the use of a medical device called Portable Neuromodulation Stimulator or PoNS as a short-term treatment for walking difficulties in people with multiple sclerosis (MS). PoNS, developed by Helius Medical Technologies, is a non-invasive medical device…
March 26, 2021 News by Marisa Wexler, MS Rituximab Fails to Lessen Brain Inflammation in Progressive MS Trial Injecting rituximab — a cancer therapy sometimes used in multiple sclerosis — into the spinal canal of people with progressive forms of MS did not demonstrably lower inflammation or improve clinical conditions, according to the results of a small trial. “Contrary to the initial high expectations, no clear-cut effect on…
March 23, 2021 News by Marisa Wexler, MS Certain Factors Worsen Outcomes in MS Patients With COVID-19 People with multiple sclerosis (MS) who have more extensive mobility issues are more likely to have worse outcomes from COVID-19, a new study indicates. The study findings also indicate that COVID-19-associated outcomes are worse among MS patients who are Black, older, have heart-related diseases, and who were treated with…
March 19, 2021 News by Marisa Wexler, MS Ponvory (ponesimod) Approved for Adults With Relapsing Forms of MS The U.S. Food and Drug Administration (FDA) has approved Ponvory (ponesimod) as an oral treatment for adults with relapsing forms of multiple sclerosis (MS). The approval covers clinically isolated syndrome, relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS). The treatment is taken as a…
March 9, 2021 News by Marisa Wexler, MS Novartis, iHeartRadio Team Up for ‘A Night for MS Awareness’ on March 11 In recognition of National Multiple Sclerosis (MS) Awareness Month — celebrated throughout March — Novartis and iHeartRadio are teaming up on a virtual event to celebrate the resilient spirit of people affected by MS. Called “A Night for MS Awareness,” the event will be streamed on…
March 5, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Taking Medication During Pregnancy Reduces Healthcare Costs Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25–27. Go here to see the latest stories from the conference. Women with multiple sclerosis (MS) who continue taking disease-modifying therapies (DMTs) throughout pregnancy accrue lower non-maternity healthcare…
March 3, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Reduced Methionine in Diet Eased Symptoms in MS Mice Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25–27. Go here to see the latest stories from the conference. Reducing the essential amino acid methionine in the diet lessened multiple sclerosis (MS)-like symptoms in a mouse model of…
March 3, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Dietary Restriction May Limit Severity of MS Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25–27. Go here to see the latest stories from the conference. Dietary restriction can lessen the severity of multiple sclerosis (MS) by modulating levels of fat-related hormones, new research…
March 3, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Research Finds Race- and Ethnicity-based Differences in MS Therapies Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25–27. Go here to see the latest stories from the conference. Clinical characteristics of multiple sclerosis (MS) patients, including their response to therapies, vary based on race and ethnicity,…
March 2, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Leptin’s Pro-inflammatory Effects May Link Obesity to MS Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25–27. Go here to see all the latest stories from the conference. The fat-related hormone leptin has pro-inflammatory effects on immune cells, new data show, findings that help in better…
March 1, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Neurologist Calls for Trial Testing Estrogen Therapy at Menopause Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25–27. Go here to see all the latest stories from the conference. At the ACTRIMS Forum 2021, Rhonda Voskuhl, MD, a neurology professor at the University…
February 26, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Young Brain Fluid (CSF) Rejuvenates Memory in Mice Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25-27. Go here to see all the latest stories from the conference. Factors in the cerebrospinal fluid (CSF) surrounding the brain and spinal cord change with age and can affect…
February 25, 2021 News by Marisa Wexler, MS #ACTRIMS2021 – Better Strategies Needed to Help Socioeconomically Disadvantaged Patients Editor’s note: The Multiple Sclerosis News Today news team is providing in-depth and unparalleled coverage of the virtual ACTRIMS Forum 2021, Feb. 25-27. Go here to see all the latest stories from the conference. People with multiple sclerosis (MS) who are less socioeconomically advantaged tend to have faster rates…
February 24, 2021 News by Marisa Wexler, MS Physical Inactivity, Smoking Linked to Patient Fatigue People with multiple sclerosis (MS) who smoke tobacco or are not physically active are more likely to experience fatigue that interferes with their daily life, a new study indicates. The findings suggest that physical exercise and quitting smoking could help ease fatigue in people with MS. The study, “…
February 18, 2021 News by Marisa Wexler, MS EVOLUTION Trials Testing Evobrutinib Now Recruiting Two global Phase 3 clinical trials testing the investigational oral medication evobrutinib are recruiting participants with relapsing forms of multiple sclerosis (MS). The two identically-designed trials — EVOLUTION RMS 1 (NCT04338022) and EVOLUTION RMS 2 (…
February 17, 2021 News by Marisa Wexler, MS Survey: Patients, Nurses Prefer Sensoready Autoinjector Pen People with multiple sclerosis (MS) and their nurses prefer the Sensoready autoinjector pen for subcutaneous self-administration of Kesimpta (ofatumumab) over other methods for injecting treatments, according to a survey. The survey was conducted by Novartis, which markets Kesimpta. Full findings from the survey will be presented at…
February 9, 2021 News by Marisa Wexler, MS Zeposia Tablets Approved in Scotland to Treat Active RRMS The Scottish Medicines Consortium (SMC) has approved Zeposia (ozanimod) for the treatment of active relapsing-remitting multiple sclerosis (RRMS). Zeposia is sold as a tablet, to be taken by mouth once daily. The SMC has recommended that Zeposia be prescribed for people with RRMS who experience relapses or have evidence of…
February 3, 2021 News by Marisa Wexler, MS Protein-targeting Therapy Found to Lessen Inflammation in Preclinical Study A novel medication targeting the protein folate receptor-beta (FR-beta) decreased inflammation and brain damage in a rat model of multiple sclerosis (MS). The findings were published in the Journal of Neuroinflammation, in the study “Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of…
February 2, 2021 News by Marisa Wexler, MS FDA Approves Plegridy as Intramuscular Injection for Relapsing MS The U.S. Food and Drug Administration (FDA) has approved an intramuscular injection formulation of Plegridy (peginterferon beta-1a) to treat people with relapsing forms of multiple sclerosis (MS). This formulation, for injection directly into muscle, is what is typically used to deliver the flu shot. According to Biogen, Plegridy’s…
February 1, 2021 News by Marisa Wexler, MS CHMP Favors Kesimpta for Adults With Relapsing MS in Europe A branch of the European Medicines Agency (EMA) has recommended that Kesimpta (ofatumumab) be approved and made available to treat relapsing forms of multiple sclerosis (MS) in adults with active disease. A final decision from the European Commission (EC) is expected in about two months. Typically, the EC follows…
January 28, 2021 News by Marisa Wexler, MS NfL Mirrors Some Life Quality Aspects Felt by Patients, More Work Needed Levels of neurofilament light (NfL), a protein marker of neuronal damage, appear to capture some aspects of patient‐perceived physical and functional abilities with multiple sclerosis (MS), as well as their utilization of select healthcare services, a real-world study suggests. Its researchers, however, stress that more work is needed before NfL levels…
January 21, 2021 News by Marisa Wexler, MS Levels of Fatty Acid Low in MS Patients, Likely Affecting Immune System Oleic acid, a type of fatty acid, is important for the function of immune cells that are dysregulated in multiple sclerosis (MS), an early study shows. A diet rich in oleic acid may potentially be beneficial for these patients, although researchers emphasized the need for more studies. The study,…
January 20, 2021 News by Marisa Wexler, MS Clene Awaits US Patent Covering Gold Nanocrystals’ Use in Treating MS Clene Nanomedicine has been notified it will be given a U.S. patent, as requested, covering an invention using the company’s already patented gold nanocrystals for the treatment of multiple sclerosis (MS). A Notice of Allowance was received by the company. These notices are issued by the U.S. Patent…
January 12, 2021 News by Marisa Wexler, MS Helius Provides More Information to FDA About PoNS Device Helius Medical Technologies has submitted its response to the U.S. Food and Drug Administration (FDA)’s request for more information about the company’s application for de novo classification and clearance of its portable neuromodulation stimulator (PoNS) device to help treat walking difficulties in people…
January 8, 2021 News by Marisa Wexler, MS Target Tissues of Immune Attacks Too Often Ignored in Research, Study Says To fully understand autoimmune diseases like multiple sclerosis (MS), it is necessary to study not just the immune system, but also the tissue that the immune system is attacking, a study suggests. “We must move away from the present ‘immune-centric-only’ view of autoimmune diseases,” Decio Eizirik, MD, PhD, study…
January 6, 2021 News by Marisa Wexler, MS MSAA Hosting 8th Webinar on COVID-19 and MS The Multiple Sclerosis Association of America (MSAA) is hosting a webinar in which experts will discuss the COVID-19 pandemic and its impact on multiple sclerosis (MS). The webinar, “What You Need to Know About COVID-19 and MS: Program 8,” will take place at 8 p.m.
December 15, 2020 News by Marisa Wexler, MS Study Seeks to Better Understand How MS Affects Memory A new research project will seek to better understand the biological processes that drive memory problems in people with multiple sclerosis (MS), as a better understanding of these processes may open new avenues for intervention. The four-year study is titled “Neuroimaging of Hippocampally Mediated Memory Dysfunction in…
November 25, 2020 News by Marisa Wexler, MS Tablet-based Video Game Could Help Measure Cognitive Impairment in MS, Study Shows People with multiple sclerosis (MS) may have cognitive defects that cannot be detected using conventional paper-and-pen tests but that can be assessed with computer-based tests, a new study shows. The findings also indicate that people with MS may be more susceptible to cognitive impairment when the brain has to address increased…
November 23, 2020 News by Marisa Wexler, MS ChariotMS to Test Mavenclad in SPMS, PPMS Patients With Little Ability to Walk An upcoming Phase 2 clinical trial, called ChariotMS, will test whether Mavenclad (cladribine) can slow a worsening of hand and arm function in people with progressive multiple sclerosis (MS) and very limited walking abilities. Patients reliant on wheelchairs or aids to walk even short distances generally have…