The U.S. Food and Drug Administration’s approval of Kesimpta (ofatumumab) this month is a pretty big deal. Kesimpta is a once-a-month injectable disease-modifying therapy. There’s nothing else like it, because Kesimpta targets B-cells in the immune system. Until now, only infusions, such as Ocrevus (ocrelizumab) and Lemtrada (alemtuzumab), have done that. After a first injection, Kesimpta can be self-administered. It seems to me that the efficacy of a B-cell attacking medication combined with the ease of self-injection should be a winner. Would you agree?
According to Novartis, Kesimpta is the first approved MS therapy targeting B-cells that can be taken at home via an under-the-skin (subcutaneous) injection, using an autoinjector pen, once a month. The medication is expected to be available to patients in the U.S. in early September.
Many of us had chickenpox as a child, and some have been inoculated against it, creating immunity. But here’s a report of one man who, after being treated for his MS with Ocrevus (ocrelizumab), lost his immunity to the virus that causes chickenpox and shingles. While this is just a single case study, you might want to ask your neurologist about it if you’re being treated with Ocrevus or are considering that therapy.
A recent court ruling that invalidated the patent protecting Tecfidera (dimethyl fumarate) has cleared the way for Mylan to begin distributing a generic version of that DMT. Without the ruling against Tecfidera’s manufacturer, Biogen, a generic wasn’t likely to become available before the patent’s expiration in 2028. Biogen says it intends to appeal the ruling, but Mylan has begun marketing its generic version anyway.
The generic, now approved by the U.S. Food and Drug Administration (FDA), is the first generic of any MS treatment available in an oral solid — capsule or tablet — form in the U.S.
Urinary tract infections frequently are a problem for people with MS, due to the difficulty many of us have urinating or emptying our bladder completely. So, it seems common sense to think that treatments to improve URIs are needed. If you had any doubt, here’s a study that backs up that conclusion.
Urinary tract infections are a common cause of hospitalization among people with multiple sclerosis (MS), especially older patients with progressive disease, and more attention should be given to their bladder, catheter, and general physical care, a U.K. study reported.
These infections are often linked to an emergency hospital admission, and carry a risk of death as well as higher costs to the healthcare system, its researchers wrote.
Have you browsed through our MS News Today Forums yet? I’m co-moderator there, and I hope you’ll give us a click to join the conversation.
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Note: Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The opinions expressed in this column are not those of Multiple Sclerosis News Today or its parent company, BioNews, and are intended to spark discussion about issues pertaining to multiple sclerosis.
Diagnosed with MS at age 32 in 1980, Ed has written the “MS Wire” column for Multiple Sclerosis News Today since August 2016. He presents timely information on MS, blended with personal experiences. Before retiring from full-time work in 2012, Tobias spent more than four decades in broadcast and on-line newsrooms as a manager, reporter, and radio news anchor. He’s won several national broadcast awards. As an MS patient communicator, Ed consults with healthcare and social media companies. He’s the author of “We’re Not Drunk, We Have MS: A tool kit for people living with multiple sclerosis.” Ed and his wife split time between the Washington, D.C. suburbs and Florida’s Gulf Coast.
Diagnosed with MS at age 32 in 1980, Ed has written the “MS Wire” column for Multiple Sclerosis News Today since August 2016. He presents timely information on MS, blended with personal experiences. Before retiring from full-time work in 2012, Tobias spent more than four decades in broadcast and on-line newsrooms as a manager, reporter, and radio news anchor. He’s won several national broadcast awards. As an MS patient communicator, Ed consults with healthcare and social media companies. He’s the author of “We’re Not Drunk, We Have MS: A tool kit for people living with multiple sclerosis.” Ed and his wife split time between the Washington, D.C. suburbs and Florida’s Gulf Coast.
I’m sorry that Ocrevus isn’t working as well for you as it had been. Have you and your neurologist discussed Lemtrada? It’s not approved for PPMS but it seems to be a highly effective DMT.
I have p.pm.s..been on ocrevus infusion for 3yrs.is loosingits effectivness .need something different soon.
Hi David,
I’m sorry that Ocrevus isn’t working as well for you as it had been. Have you and your neurologist discussed Lemtrada? It’s not approved for PPMS but it seems to be a highly effective DMT.
Ed
Is there any medication for Transverse Myelitis.
Hi Kelly,
Here’s some info that may help: https://www.mayoclinic.org/diseases-conditions/transverse-myelitis/diagnosis-treatment/drc-20354730
Ed