November 10, 2023 News by Marisa Wexler, MS ATA188 fails to outperform placebo in EMBOLD clinical trial ATA188, an experimental cell therapy targeting the Epstein-Barr virus, failed to outperform a placebo at easing disability levels in people with nonactive progressive forms of multiple sclerosis (MS), according to data from the Phase 2 portion of the EMBOLD clinical trial. The medication also showed no signs of…
October 31, 2022 News by Lindsey Shapiro, PhD #ECTRIMS2022 ā ATA188 Still Easing Disability in Progressive MS Patients The investigational immunotherapy ATA188 continues to ease disability and prevent brain tissue shrinkage in people with progressive forms of multiple sclerosis, according to the data, now reachingĀ up to four years, on patients in an ongoing clinical trial. People who achieved confirmed disability improvement also showedĀ potentialĀ signs of remyelination, or…
July 18, 2022 Columns by Ed Tobias MS News That Caught My Eye Last Week: ATA188 in Progressive MS, Early Symptoms, Yoga, Rituximab EMBOLD Study of ATA188 in Progressive MS Is Given Go-ahead Is this another small step toward an MS cure? AT188 is an experimental therapy designed to kill cells infected with the Epstein-Barr virus (EBV). As you probably know, researchers have found a lot of evidence that EBV is connected…
July 14, 2022 News by Marisa Wexler, MS EMBOLD Study of ATA188 in Progressive MS Is Given Go-ahead An independent committee of experts has recommended that the Phase 2 portion of the EMBOLD clinical trial continue as planned without a sample size adjustment, following an analysis of safety and effectiveness data. The trial is testing Atara Biotherapeutics‘ experimental medication ATA188 in progressive forms of multiple…
May 13, 2022 Columns by Ed Tobias Hunt for EBV Vaccine Gets a Boost From NIH The National Institutes of Health (NIH) is joining the search for a vaccine to attack the Epstein-Barr virus (EBV). This is a big deal for people with multiple sclerosis, because carrying the virus is thought to play a significant role in the development of MS. In fact,…
April 25, 2022 Columns by Ed Tobias MS News That Caught My Eye Last Week: Bone Marrow Infusions, ATA188, Enhanced MRIs, Costs Progressive MS Trial Finds Repeat Bone Marrow Infusion Safe, Feasible Two bone marrow transplant studies are reported in this story. The first, a tiny trial of just six people, assessed the safety of this procedure, which involves harvesting cells from their bone marrow, then infusing them into the bloodstream…
April 19, 2022 News by Marta Figueiredo, PhD Atara Planning Phase 3 Trials of ATA188 in Non-active SPMS, PPMS Atara BiotherapeuticsĀ plans to launch two Phase 3 clinical trials of its investigational immunotherapy ATA188 in people with non-active, progressive forms of multiple sclerosisĀ (MS). Whether efforts for these trials will go forward, however, depends on positive results from an interim analysis of the Phase 2 portion of the…
April 13, 2022 News by Marta Figueiredo, PhD Australia Sets Aside $18M to Support MS Trials, EBV Research The Australian government has announced that a record AU$18 million (about $13.5 million) from the Medical Research Future Fund will be used to support research intoĀ multiple sclerosisĀ (MS) as part of its 2022ā23 budget. Grant opportunities willĀ focus on increasing access to clinical trials and speeding the development of effective…
February 1, 2022 News by Marisa Wexler, MS Atara, Fujifilm Enter Deal to Produce Cell Therapies Atara Biotherapeutics has reached an agreement withĀ Fujifilm Diosynth Biotechnologies for the production of its cell therapy pipeline, including ATA188, an experimental therapy being investigated for the treatment of progressive multiple sclerosis (MS). Under the agreement, Fujifilm will acquire Ataraās T-Cell Operations and Manufacturing (ATOM) facility in Thousand…
January 13, 2022 News by Patricia Inacio, PhD Atara, Imeka Team Up to Bring Advanced Imaging to ATA188 Trial Atara Biotherapeutics has partnered with Imeka to use its proprietary biomarker imaging technology in the ongoing EMBOLD Phase 2 clinical trial, which is investigating ATA188 for the treatment of progressive forms of multiple sclerosis (MS). The imaging technology will be used to determine if Atara’s ATA188…
September 30, 2021 News by Steve Bryson, PhD #ECTRIMS2021 – ATA188 Benefits in SPMS, PPMS Hint at Remyelination An investigational immunotherapy, ATA188Ā showed it could reverse disability and improve exercise capacity in people with progressive forms of multiple sclerosis (MS), Atara Biotherapeutics, its developer, reported in an update on a Phase 1 trial and its long-term extension study. EMBOLD trial findings based on MRI brain imaging…
September 8, 2020 News by Joana Carvalho, PhD #MSVirtual2020 – ATA188 Safe, Early Efficacy Seen in Progressive MS Trial ATA188, Atara Biotherapeuticsā investigative T-cell immunotherapy, is safe, well tolerated, and able to ease disability and improve exercise capacity in patients with progressive forms of multiple sclerosis (MS), according to one-year data from a Phase 1 trial and its long-term extension study. Findings also showed that, after…
June 19, 2020 News by Forest Ray PhD 1st Progressive MS Patient Enrolls in Phase 1b Study of Cell Therapy ATA188 Atara Biotherapeutics has enrolled a first patient in a clinical trialĀ testingĀ ATA188, its off-the-shelf T-cell immunotherapy for people with progressive forms of multiple sclerosis (MS). The Phase 1b trial (NCT03283826) follows promising safety and tolerability results from its open-label Phase 1a part, including a…
May 29, 2020 News by InĆŖs Martins, PhD Cell Therapy ATA188 Safely Easing Disability in Progressive MS, Trial Reports Atara Biotherapeutics‘ cell-based therapy ATA188 is safe and well-tolerated in people with progressive forms of multiple sclerosis (MS), and induces a sustained reduction in disability in a dose-dependent manner, findings from the first part of a Phase 1 clinical trial show. ATA188 had an…
April 7, 2020 News by InĆŖs Martins, PhD Atara Pauses Enrollment in Part 2 of Immunotherapy Trial in PPMS and SPMS InĀ response to theĀ COVID-19 pandemic, Atara Biotherapeutics has temporarily paused patient enrollment in the second and randomized part of its ongoing Phase 1 clinical trial investigating ATA188 in people with progressive forms of multiple sclerosis (MS). People treated in the first, open-label part of this trial, however,…
September 19, 2019 News by Jose Marques Lopes, PhD #ECTRIMS2019 – Cell Immunotherapy ATA188 Showing Safety, Hints of Effectiveness in Progressive MS in Phase 1 Trial People with progressive forms of multiple sclerosis (MS) and past exposure to the Epstein-Barr virus are responding to a potentialĀ immunotherapy known as ATA188, tolerating the treatment well and with signs that suggest effectiveness, early updated data from an ongoing Phase 1 trial show. The research, ā…
May 23, 2019 News by Alberto Molano, PhD Early Safety Data from Phase 1 Study of Immunotherapy in Progressive MS Patients To Be Detailed at EAN Early, positive safety results from a Phase 1 trial testing a potential immunotherapy,Ā ATA188, in people with progressive multiple sclerosisĀ will be detailed at the 5th Congress of the European Academy of Neurology (EAN) late next month, its developer, Atara Biotherapeutics, announced. ATA188 is an investigational and “off-the-shelf”…
November 21, 2018 News by Patricia Inacio, PhD Phase 1 Trial of ATA190 Cell Therapy Shows Promise in Treating Progressive MS Atara Biotherapeuticsā investigational ATA190, a cell therapy that wipes out immune B-cells infected with the Epstein-Barr virus (EBV), led to neurological improvements and reduced symptoms in patients with primary and secondary progressive multiple sclerosis (MS), a Phase 1 trial shows. The trial results were published in the Journal…
June 19, 2018 News by Patricia Inacio, PhD Atara Biotherapeutics Study Links Epstein-Barr Virus Infection with MS Analysis of post-mortem brain samples from multiple sclerosis (MS) patients and healthy individuals (without neurologic disease) showed that while signs of Epstein-Barr virus (EBV) infection are present in both groups of brains, EBV-positive immune cells were more prevalent and densely populated in the MS brain. The study reporting those findings,…
January 12, 2018 News by Patricia Silva, PhD Atara to Extend Phase 1 Trial of Potential Immunotherapy for All MS Forms to US Patients Atara Biotherapeutics has received a green light to enroll U.S. patients into a Phase 1 trial of ATA188 for progressive or relapsing-remitting multiple sclerosis (MS). The study was initially launched in Australia, but with the U.S. Food and Drug Administration (FDA) having cleared the companyās application, the trial…
October 24, 2017 News by Iqra Mumal, MSc Atara Biotherapeutics Starts Phase 1 Clinical Trial of Its MS Immunotherapy ATA188 Atara BiotherapeuticsĀ has startedĀ a Phase 1 clinical trial to assess ATA188’s safety and potential to treat progressive or relapsing-remitting multiple sclerosis. ATA188 is the companyās next-generation T-cell immunotherapy. It targets Epstein-Barr virus antigens that play an important role in the development of MS. An antigen is a molecule capable of…
August 14, 2017 News by Patricia Inacio, PhD Phase 1 Trial Recruitment Complete for Ataraās ATA188 T-cell Immunotherapy for Progressive MS Atara BiotherapeuticsĀ recently published anĀ updateĀ ofĀ the companyās quarterly financial results and operational highlights, including the advancement ofĀ itsĀ T-cell based immunotherapy strategies for multiple sclerosis (MS) and cancer. One of the investigational therapies featured in the report is ATA188, a potential treatment for MS.
April 24, 2017 News by Patricia Silva, PhD ATA188, Which Kills B-Cells Targeting Epstein-Barr Virus, Shows Promise as MS Treatment An investigational treatmentĀ called ATA188 that wipes out B-cells targeting the Epstein-Barr virus (EBV) has shown promise as a multiple sclerosis treatment, a Phase 1 clinical trial involving a small patient group indicates. The trial, conducted in Australia, covered six people with primary or secondary progressive MS. B-cells are a…