May 4, 2018 Columns by Ed Tobias Website Shows How Much Money Your Doctor Gets from Big Pharma Biogen, a pharmaceutical company that markets half a dozen MS therapies, is accused of paying doctors to prescribe its medications. A former Biogen employee claimed that the company paid fake consulting and speaking fees to doctors who prescribed Avonex (interferon beta-1a) and Tysabri (natalizumab) in 2009 and 2010.Ā The company…
April 3, 2018 News by Patricia Inacio, PhD Study Receives $1.7M from NIH to Research New Therapeutic Strategies for MS, Others A new project aimed at boosting the development of new therapies for multiple sclerosis (MS) and other demyelinating diseases recently won $1.7 million in funding from the National Institutes of Health (NIH). In the five-year study, a research team at theĀ University at BuffaloĀ (part of the State University…
March 14, 2018 News by Alice MelĆ£o, MSc National MS Society to Award $433,800 to Support 10 Pilot Research Projects The National Multiple Sclerosis Society will award $433,800 to 10 high-risk pilot studies that will quickly evaluate new strategies and interventions and enhance knowledge about multiple sclerosis (MS). According to a press release, the award winners will address different aspects of the disease, including potential treatments for fatigue and loneliness, to improve patients' walking abilities, and a strategy to change gut bacteria effects in MS. The year-long Pilot Research Grant program is a way to support early-stage research projects to quickly test their effectiveness. The MS Society also said that additional projects will be awarded this year. Results of a recent survey of approximately 300 pilot grant recipients revealed the program successfully promotes new ideas and brings new researchers to the MS field. About 90 percent of the respondents agreed that the financial support was very important for their research project. In 85 percent of cases, the grant supported new ideas, and in 56 percent it allowed support for additional grants. These pilot grants allow researchers to obtain preliminary data so they can decide to apply for additional funding, if the project looksĀ promising, or to put the idea to rest.
December 7, 2017 News by Alice MelĆ£o, MSc University of Illinois Researchers Win $300,000 Falk Award to Improve MS Drug Delivery A research team at theĀ University of Illinois College of MedicineĀ has received $300,000 from the Falk Medical Research Trust to develop a novel drug delivery method that could improve the treatment of patients with multiple sclerosis. Established in 1979, the Dr. Ralph and Marian Falk Medical Research Trust - Catalyst Award is granted every year to a dozen U.S. research groups. It provides one year of funding to high-risk, high-reward projects to complete preliminary studies. Catalyst Program winners who achieve their goals can then enroll in the Falk Transformational Awards Program, which offers $1 million for two years to further support the projects. The UIC team, led by Ernesto Bongarzone and Maria Givogri, hope to transform naturally occurring small vesicles released by several cell types into drug targeted delivery vehicles. Cells commonly use these vesicles to communicate with each other. They pack inside the vesicles with many cell products, like proteins and small RNA molecules, then release them into the bloodstream and cerebrospinal fluid. These vesicles can travel to distant places in the body until they find and fuse with their target cell, dumping their cargo. However, the content of vesicles may not always be good, as they have been shown to play a role in spreading cancer, said fellow anatomy and cell biology professor Givogri. "There is much more to learn about how they function in this way,ā she added. The team will use the Catalyst Award to test different methods of vesicles production from mesenchymal stem cells. They will also engineer these vesicles to specifically target oligodendrocytes in the brain and spinal cord. Oligodendrocytes are cells that specialize in producing the nerve cellās protective myelin layer. The efficacy and safety of this new delivery method will be tested in mice. After completing these preliminary studies, the team expects to apply for further funding. The UIC researchers plan to use the vesicles to transport and deliver small RNA molecules, called microRNAs, that can boost myelin production.
September 15, 2017 News by Alice MelĆ£o, MSc Five Research Projects Totaling $38 Million to Compare Effectiveness of MS Treatment Strategies The Patient-Centered Outcomes Research InstituteĀ has awarded $38 million in grants for five projects that compare the effectiveness of different multiple sclerosis treatment strategies. A key aim of the research is to improve knowledge about the therapiesĀ to help doctors and patients choose the healthcare option that best meets patients’ needs.Ā The…
July 27, 2017 News by Joana Fernandes, PhD Kezar Life Sciences Raises $50M to Advance Clinical Testing of Potential MS Treatment Kezar Life Sciences announced that it is planning to move ahead with clinical testing of KZR-616, a potential treatment for multiple sclerosis (MS) and other autoimmune diseases and inflammatory disorders. The company recently concluded a Phase 1 safety study of the treatment, and raised $50 million in investment funding to support its development. KZR-616 is a first-in-class selective immunoproteasome inhibitor, meaning it works by blocking abnormal protein degradation. Cells eliminate proteins by sending them to a specialized cell compartment known as the proteasome. In immune cells, the proteasome is called immunoproteasome, and it regulates several selective inhibitors and participates in the regulation of the immune response associated with inflammatory diseases such as MS, rheumatoid arthritis, Crohn's disease, and lupus. "We are pleased with the results of our healthy volunteer study, and grateful for the support of such an excellent group of investors to finance our upcoming clinical trials," John Fowler, Kezar Life Sciencesā CEO, said in a news release. "The strong demand for this financing reflects growing excitement for the potential of immunoproteasome inhibition in treating autoimmune disorders and recognizes the clear leadership position enjoyed by Kezar." The Phase 1 trial enrolled 82 healthy subjects, who were assigned to receive either KZR-616 or placebo. In total, 61 volunteers were given KZR-616 as single or multiple doses at varying dose levels to identify the optimal dose for both tolerability and proteasome inhibition. Results will be presented at the American College of Rheumatology's Annual Meeting to be held in San Diego in November. "These initial clinical trial results demonstrate that KZR-616 is achieving the desired levels of immunoproteasome inhibition that correlate with anti-inflammatory activity seen in laboratory models,ā said Christopher Kirk, PhD, company president and CSO. āBy selectively targeting the immunoproteasome, we believe we can avoid the toxicities associated with dual proteasome inhibitors like Velcade and Kyprolis." The Series B financing round was led by Cormorant Asset Management and Morningside Venture and raised $50 million to support the development of KZR-616. Kezar announced it has the support of new investors, including Cowen Healthcare Investments, Pappas Ventures, Qiming Venture Partners, and Bay City Capital. "Cormorant is pleased to support Kezar as it enters an exciting series of patient studies, the first ever with a selective immunoproteasome inhibitor," said Bihua Chen, founder of Cormorant Asset Management. "While much work remains, I believe KZR-616 has the potential to be a transformative treatment in autoimmunity."
July 26, 2017 News by Alice MelĆ£o, MSc Wealthy Oilman with Multiple Sclerosis Funds Canadian Studies for Promising MS Therapy Canadian oilman Hank Swartout made a fortune as longtime founder and CEO of Precision Drilling. The Calgary native mortgaged his house to start the company, which by the time he left in 2009 had annual sales of $7 billion. But an early diagnosis of multiple sclerosis (MS) at the age…
May 11, 2017 News by Patricia Silva, PhD National Multiple Sclerosis Society Commits to $17 Million for 43 Research Projects The National Multiple Sclerosis SocietyĀ is pumping $17 million intoĀ 43 research projectsĀ that represent almost half of its $40-million research funding commitment in 2017. Among the projectsĀ are trials evaluating intermittent fasting as a way to harness inflammation and stem cell research. A growing number of studies indicate thatĀ stem cells can slow…
January 26, 2017 Columns by Laura Kolaczkowski Join Me and Advocate for MS One of my sisters called to let me know that CNN was doing live coverage of the Womenās March that was taking place in all 50 U.S. states, as well as many other countries. While we talked, one of the speakers came on and observed that the issues facing…
December 19, 2016 News by Patricia Silva, PhD 9 Research Teams at Virginia Universities Awarded Grants into Studies of Brain Nine research teams at the University of VirginiaĀ and Virginia TechĀ will be awarded grants totalingĀ $550,000 for studies addressing issues related to brain development and brainĀ function in health and disease. Among theĀ university-fundedĀ projects receiving between $50,000 and $70,000 each is research into potentialĀ new treatmentsĀ for multiple sclerosis. āWe are planting seeds that…
November 28, 2016 News by Charles Moore Partnership Receives $1.2M from California Initiative to Advance Precision Medicine for MS Sutter Health, a not-for-profit healthcare network serving more than 100 northern California communities, has been awarded $1.2 million by theĀ California Initiative to Advance Precision MedicineĀ (CIAPM) to support patients living with multiple sclerosis (MS) and help improve how health matters are targeted and treated across the entire state.
November 2, 2016 News by Charles Moore AXIM Advances Clinical Trials for MS Relief with Medical Cannabinoid Chewing Gum AXIM BiotechĀ has closed on a private funding round that will enable itĀ to continue clinical trials for a variety of conditions, including its pharmaceutical candidate MedChew Rx, a patented cannabinoid release chewing gum for treating pain and spasticity in multiple sclerosis (MS). According to a press releaseĀ from SECFilings.com,…
October 28, 2016 News by Patricia Silva, PhD AXIM Moving Ahead with Testing of Cannabinoid Products, Including Chewing Gum for MS Patients AXIM Biotechnologies Ā announced it has secured financing from private sources to continue its testing of medicalĀ cannabinoid products as potential treatments forĀ multiple indications, includingĀ pain and spasticity in people with multiple sclerosis (MS). Specifically, AXIM Ā is testing pharmaceutical delivery systems andĀ active ingredients for itsĀ medical marijuana line. āThis financing provides us with…
October 17, 2016 News by Patricia Silva, PhD National Multiple Sclerosis Society Commits $10.5M to Fund 42 Research Efforts The National Multiple Sclerosis SocietyĀ announced thatĀ is investing more than $10.5 million to support an anticipatedĀ 42 new research projects intoĀ multiple sclerosis (MS), part of its commitmentĀ to scientificĀ efforts aimed atĀ stopping MS, restoring lost function to patients, and, ultimately, ending the disease forever. The dedicated fundingĀ is part of aĀ projected society investment of…
September 14, 2016 News by Patricia Silva, PhD #ECTRIMS2016 – MS Care in Latin America Suffers from Lack of Healthcare Resources In a session titled “Challenges for care and research in MS outside Europe and North America” at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) 2016 CongressĀ Sept. 14-17 in London, researchers from Latin America shared the obstaclesĀ of scientists and multiple sclerosis (MS) patients in the…
September 14, 2016 News by Patricia Silva, PhD #ECTRIMS2016 – MS Care and Research Lagging in Middle East, Experts Say Multiple sclerosis (MS) care and research is lagging behind in the Middle East compared to countries in Europe and North America, according to research presented at the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) 2016 CongressĀ taking placeĀ in London through Sept. 17. Two presentations inĀ a session titled “…
September 6, 2016 News by Patricia Silva, PhD Young MS Researchers Invited to Apply for Marilyn Hilton Award The Conrad N. Hilton FoundationĀ announced thatĀ nominations are now being accepted for the Marilyn Hilton Award for Innovation in Multiple Sclerosis Research.Ā The award aims to stimulate newĀ and potentially groundbreaking research intoĀ progressive multiple sclerosis (MS), Ā and the Foundation expects to distributeĀ to $4 million in grants over five years, supporting the…
May 26, 2016 News by BioNews Staff MS Australia Puts Out an Owner’s Manual for ‘MS Bike’ and Anyone Willing to Take It for a Spin A bicycle specially designed to mimic the symptoms of multiple sclerosis (MS) now has its own owner’s manual, and the group behind the bike’s creation is inviting anyone interested to build their own experience of the spasticity and physical discomforts so well-known to people with the disease. The manual, which…
May 25, 2016 News by InĆŖs Martins, PhD Mitochon Raises $1.6M to Begin Clinical Tests of Mitochondrial Modulators for MS Mitochon PharmaceuticalsĀ announced the completionĀ of a second year of financing, raising a total $1.6 million to advance itsĀ lead compound, MP101, a mitochondrial targeted neuro-protective agent, into clinical testing. The company is developingĀ mitochondrial modulators for patients with neurodegenerative diseases ranging from Alzheimer’s and Parkinson’sĀ toĀ multiple sclerosis (MS). A number of studies have…
April 8, 2016 News by Patricia Silva, PhD National MS Society Invests $25.3M to Support 60 New Research Projects, Train Clinicians TheĀ National Multiple Sclerosis SocietyĀ announced that it has investedĀ $25.3 million to support nearly 60 new research projects aiming to better understand and treatĀ multiple sclerosis (MS), and seven clinical training awards as part of its strategic approach to eventuallyĀ curingĀ MS. This investment is part of the Society’s plan to commit a…
March 17, 2016 News by Margarida Azevedo, MSc MS Research Australia Funds Projects into Targeted Gene Suppression, Drug Delivery Professor Steve Wilton and Dr. Rakesh Veedu from Murdoch Universityās Centre for Comparative GenomicsĀ in Western Australia received project grants of $50,000 and $25,000, respectively, to investigate and develop new methods for the treatment of multiple sclerosis (MS). The grants are part of $1.834 million in research fundingĀ givenĀ by MS…
January 14, 2016 News by Patricia Silva, PhD Simple MS Blood Test Said to Be Able to Diagnose Disease at Symptom Onset IQuity Labs, which specializesĀ in diagnostic tests for autoimmune and other diseases, recently announced that it has received $2 million in seed funding to support the launch of itsĀ test panels, diagnostic tests designed to confirm the presence or absence of disease at the very onset of symptoms. The first to…
December 3, 2015 News by Patricia Silva, PhD MS Society of Canada Helps Fund Pediatric Study of Gut Bacteria The Multiple Sclerosis Society of Canada and the Multiple Sclerosis Scientific Research Foundation recently announced the funding of new research on pediatric multiple sclerosis (MS) and on the role played by the gut microbiome in brain and autoimmune diseases. Although onlyĀ around 5% of all newly diagnosed MS cases…
November 24, 2015 News by Patricia Silva, PhD MS Society Funds 3 New Investigations into Symptom Management TheĀ Multiple Sclerosis Society (MS Society)Ā in the U.K. recently announcedĀ awards targeted towardsĀ new MS research. In total, 16 projects carefully selected by both a panel of experts and patients living with MS will share MS Society 2015 funding grants amounting toĀ Ā£1,979,879. All projects fulfilled the requirements of high scientific…
November 23, 2015 News by Patricia Silva, PhD MS Society Supports 2 Projects Advancing MS Care, Services The United Kingdom basedĀ Multiple Sclerosis Society (MS Society) recently announced Ā£1.98 million in grants toĀ new MS research projects in different disease-related areas. A panel of experts carefully selected 16 projects to be funded through the MS Societyās 2015 grant round, totaling Ā£1,979,879. All selected projects fulfill the requirements of…
November 20, 2015 News by Patricia Silva, PhD MS Society Funds 5 Projects Aiming to Cure the Disease The Multiple Sclerosis Society (MS Society) in the United Kingdom recently announced the investment of Ā£1.98 million in new MS research. After an in-depth, rigorous review process of the 58 applications submitted, 16 projects were awarded funding through the MS Societyās 2015 grant round totaling Ā£1,979,879. All applications…
November 19, 2015 News by Patricia Silva, PhD MS Society Invests in Research into Underlying Causes of Disease The Multiple Sclerosis Society (MS Society) in the United Kingdom recently announced the investment of Ā£1.98 million in new MS research. The 16 projects awarded funding through the MS Societyās 2015 grant round were thoroughly evaluated in a rigorous review process. In total, 58 projects applied forĀ MS Society…
October 13, 2014 News by Patricia Silva, PhD PHARMAC Approves Funding New RRMS Treatments in New Zealand New Zealand-basedĀ Pharmaceutical Management Agency (PHARMAC) has approved the funding of new treatments for multiple sclerosis (MS), which are expected not only to reach more patients, but also be more effective in curtailing the disease’s progressive symptoms. The therapies currently funded are meant for the treatment ofĀ …
October 3, 2014 News by Patricia Silva, PhD National MS Society Pledges $19 Million Dollars to Fund 54 New Studies 54 new multiple sclerosis (MS)Ā research and development initiatives are set to receive substantial funding in order to accelerate new therapies. The National Multiple Sclerosis Society (NMSS) announced that it has pledged $19 million to fund these new MS studies as part of their mission to better manage…
July 18, 2014 News by Patricia Silva, PhD Startup ImStem Raising Funds For Novel Stem-Cell MS Treatment Startup biotech company ImStem BiotechnologyĀ is looking to raise additional funding for their upcoming clinical trials after publishing promising research on a unique stem-cellĀ treatment used on mice withĀ multiple sclerosis. Ā The company has already received previous funding…