October 27, 2017 News by Patricia Silva, PhD #MSParis2017 ā Real-world Data Leading Way to Personalized Treatment, Biogen Says in Interview Personalized medicine is the future of multiple sclerosis treatment, and research now taking place to collect and analyze data and pinpoint biomarkers will help make possible approaches that ā one day ā will put MS into “complete remission” patient by patient, said Richard Rudick, vice president of Development Sciences at…
October 27, 2017 News by Alice MelĆ£o, MSc #MSParis2017 ā Inhibiting Protein in Brain Cells Can Rejuvenate Protective Nerve Cell Coating, Study Shows Inhibiting a protein found at high levels in immune cells located in the brain can rejuvenate myelin, the protective coating around nerve cells, according to a multiple sclerosis study in mice. Blocking the protein, known as the colony-stimulating factor 1 receptor, or CSF1R, can also prevent the immune cells from…
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 – Researchers Disagree on Feasibility of Using Disease-modifying Therapies in RIS Patients Radiologically isolated syndrome (RIS) is a rare and relatively recent condition in which people have multiple sclerosis (MS)-like brain and spinal cord lesions without showing disease activity. But since the establishment of the RIS diagnosis, researchers have not reached an agreement on whether these patients should receive MS disease-modifying therapies.
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 ā Mavenclad Is ‘Smart’ Therapy for Active Relapsing MS, Researcher Says MavencladĀ (cladribine tablets), an oral therapy byĀ MerckĀ that’s approved to treat people with active relapsing multiple sclerosis in much of Europe, is a “smart therapy” that is showing real and long-term benefit after a short treatment course, said Gavin Giovannoni, chair of neurology atĀ Barts and The London School of Medicine…
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 – Tysabri Did Improve Walking and Hand Function in Failed SPMS Trial, Researchers Say While Tysabri (natalizumab) failed to slow worsening disability in people with secondary progressive multiple sclerosis (SPMS) in a Phase 3 trial, researchers now suggest that the treatment did improve walking and arm function in people with advanced disability. Researchers presented new analyses of data from the ASCEND trial (…
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 ā MedDayās High-Dose Biotin, MD1003, Improves Disability in Progressive MS Patients MD1003, a high-dose biotinĀ developed by MedDay, slowed or prevented further disease progression among progressive multiple sclerosis (MS) patients in a Phase 3 clinical trial, researchers announced at the Oct. 25ā28 7th Joint ECTRIMS-ACTRIMS Meeting in Paris, France. The effects of the treatment were seen to be upheld over…
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 – Siponimod Leads to Dramatic Drop in MS Lesions, Phase 3 Trial Shows Novartis’Ā SiponimodĀ led to a dramatic drop in the number of inflammation patches in the brains and spinal cords of secondary progressive multiple sclerosis patients, according to a Phase 3 clinical trial. Robert Fox of the Cleveland Clinic’sĀ Mellen Center for Treatment and Research in Multiple SclerosisĀ presented the findings…
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 – Lemtrada and Tysabri More Efficient Than Older Injectables in Preventing SPMS Onset, Study Finds Sanofi Genzyme‘s Lemtrada (alemtuzumab) and Biogen’s Tysabri (natalizumab) are more effective in preventing conversion to secondary progressive multiple sclerosis (SPMS) compared to older injectable drugs, researchers from the University of Cambridge in the U.K. reported at the 7th Joint ECTRIMS-ACTRIMS MeetingĀ Oct. 25-28 in Paris. The…
October 26, 2017 News by Alice MelĆ£o, MSc #MSParis2017 ā Intellectual Enrichment Strategies May Improve Cognitive, Socio-Professional Outcomes of Pediatric-Onset MS Using strategies to promote intellectual enrichment among patients with pediatric-onset multiple sclerosis could be essential to achieving better cognitive, social, and professional performances during adult life, according to researchers at theĀ University of FlorenceĀ in Italy. The finding was theĀ subject of an oral presentation titled, āCognitive reserve is…
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 – Study Links Depression to Increased Disability in Women with MS AĀ University of British ColumbiaĀ study found a link between depression and increased disability in women with multiple sclerosis. Dr.Ā Kyla McKay said the studyĀ of more than 1,200 patients found no link between anxiety or bipolar disorder and increased disability, however. She presented theĀ findings at the 7th Joint ECTRIMS-ACTRIMS Meeting in…
October 26, 2017 News by Patricia Silva, PhD #MSParis2017 – Types of Brain and Spinal Cord Lesions Help Determine if MS Develops, Study Reports The types of brain and spinal cord inflammation patches that occur in a precursor condition to multiple sclerosis help determine whether a person develops MS in the next 15 years, a British neurologist reported today. Wallace J. Brownlee of the University College London Institute of NeurologyĀ made the observation in…
October 25, 2017 News by Patricia Silva, PhD #MSParis2017 – Researchers Suggest Propionic Acid Could Be Used as Add-on Treatment in MS Propionic acid supplements alter the composition and behavior of immune cells in multiple sclerosis (MS) patients ā likely by changing the composition of gut bacteria, according to Alexander Duscha from Ruhr University BochumĀ in Bochum, Germany. The finding, presented Wednesday at the 7th Joint ECTRIMS-ACTRIMS MeetingĀ running in Paris…
October 25, 2017 News by Patricia Silva, PhD #MSParis2017 – MOG-associated Demyelination Can Be Treated with Steroids, but Maintenance Is Required People with aĀ demyelinating disease associated withĀ antibodies against a myelin oligodendrocyte glycoprotein (MOG), most often develop episodes of optic neuritis (inflammation of the optic nerve) that can be treated with corticosteroids, according to data presented today at theĀ 7th Joint ECTRIMS-ACTRIMS MeetingĀ from Oct. 25-28 in Paris. MOG antibody-associated demyelination is a…
October 25, 2017 News by Patricia Silva, PhD #MSParis2017 – As MS Rises Worldwide, Differences Remain Evident Among Regions The numbers of people being diagnosed with multiple sclerosis is rising worldwide, though distinct differences in factors thought to drive this rise are evident among regions, according to MS data represented by researchers on patients inĀ Asia, Latin America, and the Australia-New Zealand. The data was part of theĀ session āPrevalence and…
October 25, 2017 News by Patricia Silva, PhD #MSParis2017 ā New Trial of Opicinumab, an Anti-LINGO Antibody, in MS Builds on Lessons Learned, Biogen Says Opicinumab, an investigative treatment aiming to promote remyelination in relapsing multiple sclerosis (MS) patients, will be tested in a new clinical trial ā Ā having failed at an earlier effort, but having shown promise enough in particular patients to be worth a closer look. In fact, the new AFFINITY study “is…
October 23, 2017 Columns by Ed Tobias MS News That Caught My Eye Last Week: Mavenclad, Tecfidera, Ublituximab, Ocrevus The giant ECTRIMS/ACTRIMS MS conference begins in Paris on Wednesday, Oct. 25, and this column focuses on several of the presentations on which Multiple Sclerosis News Today will be reporting during the week. #MSParis2017 ā Mavenclad Reduces Relapses, Prevents New Lesions in Many RRMS Patients, Presentations Will…
October 23, 2017 News by Patricia Silva, PhD #MSParis2017 – Biogen to Focus on Real-world Data from Range of Efforts to Understand MS In its work on multiple sclerosis (MS),Ā Biogen has adopted a comprehensive approach that ranges from Ā drug development to the exploration of real-world data and digital markers of disease. The company will showcase these efforts at the 7th Joint ECTRIMS-ACTRIMS Meeting in Paris on October 25ā28. Among its more than 80 presentations at the meeting are updates from its collaboration with Verily and Brigham and Womenās Hospital on using digital sensors that gather data on MS patients between physician visits. Biogen will also share data on the possibility of using such biomarkers to help neurologists in diagnosing and following MS patients āĀ offering information that could potentially help them in making treatment decisions given the variability of the disease in MS patients. The company is also involved in a collaboration with 10 MS centers that aims to generate data collected during routine care. The MS PATHS study includes data from physical examinations, magnetic resonance imaging (MRI) scans, and biological samples. A third and similar project ā the Big Multiple Sclerosis Data (BMSD) Network ā Ā is merging data from five MS registries, holding prospective information on nearly 140,000 patients. Taken together, these large collections of high-quality, real-world data will help researchers better understand the disease, and so, increase the potential of new treatment discoveries, Biogen says. The company is also working to discover and develop biomarkers that are not digital that may also advance the understanding of MS and its treatment. One such marker is neurofilament light, which signals damage to neuronal axons. Biogen will share data on how this marker changes over time in MS patients. Among presentations focusing on treatment development, Biogen will highlight new efforts with opicinumab . The treatment āĀ intended to repair damage by triggering remyelination āĀ failed to reach it primary goal in the Phase 2 SYNERGY trial earlier this year. Still, Ā data indicated that some trial participants did respond to the treatment. At ECTRIMS, Biogen will present an analysis of the SYNERGY data that identifies factors ā including specific MRI features ā that may be linked to a treatment response. Ā
October 23, 2017 News by Patricia Silva, PhD #MSParis2017 – Sanofi to Present Long-term Data on Lemtrada and Aubagio Use New data on how Lemtrada and Aubagio perform in a real-world setting will be the focus of Sanofi Genzyme when the company showcases its research at the upcoming 7th Joint ECTRIMS-ACTRIMS Meeting in Paris this week. Researchers will also share information about the safety of a new investigational therapy, GLD52 (GZ402668), currently in a Phase 1 safety study. The TOPAZ study is one of the main data sources for the upcoming presentations. The study, which follows relapsing MS patients who participated in the CARE MS-I and CARE MS-II extension study , is a rich source of information on long-term outcomes. Researchers will share various aspects of disease outcomes and magnetic resonance imaging (MRI) data from patients followed up to seven years, with some presentations focusing solely on those who switched from treatment with interferon beta-1a. Among the Lemtrada highlights are findings demonstrating that Lemtrada does not appear to trigger birth defects. Another presentation compared Lemtrada to Genentechās Ocrevus using a model that evaluated both the cost and effectiveness of the two drugs. The analysis suggests that Lemtrada more effectively treated relapsing MS and was also linked to lower costs over a 20-year period. Aubagio studies also focused on long-term patient data, including in people with progressive forms of relapsing MS. Data from the Phase 3 TEMSO , TOWER , and the TEMSO extension showed that Aubagio stabilized disability progression in these patients over nearly a decade. Other presentations homed in on Aubagioās ability to slow brain tissue loss and improve cognitive outcomes. Finally, Sanofi Genzyme shared initial data on its investigational antibody GLD52. The treatment is an updated form of Lemtrada, which scientists believe gives rise to fewer and milder infusion-related reactions. Data from the Phase 1 study , so far indicated that this might indeed be the case, as no severe reactions occurred in the 44 progressive MS patients in the trial. For a complete list of Sanofi Genzyme's presentations at the meeting, visit this link.
October 20, 2017 News by Patricia Silva, PhD #MSParis2017 – Mavenclad Reduces Relapses, Prevents New Lesions in Many RRMS Patients, Presentations Will Show Mavenclad reduced multiple sclerosis relapses by 79 percent and prevented the development of additional inflammatory lesions in 84 percent of patients with high disease activity, according to presentations Merck KGaAĀ will make in Paris next week. The company willĀ share a host of new data at theĀ 7th Joint ECTRIMS-ACTRIMS…
October 20, 2017 News by Patricia Silva, PhD #MSParis2017 – Alkermes to Give Updates on ALKS 8700 Studies at ECTRIMS-ACTRIMS Meeting Alkermes will showcase its work in developing a treatment that harnesses the effect of Tecfidera (dimethyl fumarate) for relapsing multiple sclerosis (MS), while lowering the risk of stomach problems at the 7th Joint ECTRIMS-ACTRIMS Meeting this month in Paris. The investigational drug, ALKS 8700, uses the same mechanism of action as Tecfidera. By building the molecule in a different way, however, the company expects it will show better tolerability. Once in the body, dimethyl fumarate turns into monomethyl fumarate (MMF), the molecule that actually impacts MS disease processes. But before giving rise to MMF,Ā dimethyl can cause side effects in users, particularly gastrointestinal. In fact, stomach problem were what causedĀ people in Tecfidera Phase 3 trials to stop the treatment. Alkermes uses a so-called prodrug approach to try to overcome this problem. By attaching a different compound to MMF āĀ which breaks away from the molecule once in the body ā Ā it is possible to deliver MMF with lesser gastrointestinal side effects, Phase 1 study data indicate. At the meeting, the company will present two posters on two clinical trials exploring ALKS 8700 in patients with relapsing-remitting MS. The first presentation, will describe a Phase 3 trial that aims to compare ALKS 8700 to Tecfidera in about 420 patients. The trial is primarily concerned with the drugās safety, and will measure the occurrence and impact of gastrointestinal side effects in the two treatment groups. The presentation will only include descriptions of patients characteristics and study design, as outcomes are yet to be analyzed. Patients who complete the Phase 3 trial will be eligible to continue in an ongoing open-label, long-term safety study, called EVOLVE-MS-1, covered in the companyās second presentation. By March 3, 2017, the study had enrolled 543 patients. In addition to describing patient characteristics, researchers will present the rates of discontinuation caused by gastrointestinal adverse events within one month of starting the treatment.
October 19, 2017 News by Patricia Silva, PhD #MSParis2017 – TG Therapeuticsā Ublituximab Depletes Harmful B-cells and Lowers MRI Lesions, Trial Shows TG TherapeuticsāĀ ublituximab nearly eradicated a type of immune B-cell believed to be involved in multiple sclerosis,Ā according to a Phase 2 clinical trial. The result was that none of the patients had a relapse during the first six months of the trial, which is continuing, researchers said. In addition,Ā ublituximabĀ reduced the brain and spinal cord lesions of the relapsing MS patients involved in the trial and prevented new ones from forming. The company will present the interim trial results in threeĀ poster presentations at theĀ 7th Joint ECTRIMS-ACTRIMS Meeting in Paris, Oct. 25-28. Meanwhile, researchers will continue to study the effectiveness of ublituximab, a B-cell-depleting antibody, versus a placebo, for another six months. The trial is being held at several U.S. medical facilities. Participants receive two initial infusions of ublituximab or a placebo on day 1 and 15 during the first 28 days. After this initial period, those in the placebo-group are also given ublituximab and followed for 52 weeks. A key trial finding was thatĀ over the initial 24 weeks of the trial, the treatment nearly wiped out a type of B-cell known as CD20 that scientists believe is involved in the development of MS. Only 1 percent of the B-cells remained after a month. While helpful immune T-cell numbers dropped slightly after the first ublituximab infusion, they bounced back quickly. Researchers also reported a reduction in patients' magnetic resonance imaging (MRI) lesions, with no new inflammatory lesions appearing during the six months. So far, none of the trial participants has had a serious adverse event. Most of the adverse events were mild or moderate and related to the infusions. The trial also demonstrated that speeding up infusions did not increase infusion-related reactions.Ā The speed-up results indicated thatĀ ā if proven effective and safe ā ublituximab will be more convenient for patients than B-cell-depleting drugs that require infusions stretching over several hours.
October 18, 2017 News by Patricia Silva, PhD #MSParis2017 – Progressive MS Research Among ECTRIMS Highlights, National MS Society Says The 7th Joint ECTRIMS-ACTRIMS Meeting, taking place in Paris this month, is one of the largest scientific conferences focused solely on multiple sclerosis (MS), and the National Multiple Sclerosis Society will be among the many interested parties attending. To get a feeling for meeting highlights and presentations the…
October 17, 2017 Columns by Ed Tobias MSParis2017 Will Look at New MS Diagnosis Criteria, and a Lot More The year’s largest gathering of multiple sclerosis “minds” starts on Oct. 25 in Paris. More than 8,000 neurologists, researchers and others who specialize in treating and curing MS will be attending MSParis2017. It’s a joint meeting of the European and the Americas Committee for Research in Multiple Sclerosis…
October 17, 2017 News by Patricia Silva, PhD #MSParis2017 – Genentech to Share Host of New Ocrevus Data at ECTRIMS-ACTRIMS Meeting GenentechĀ will present a host of new information on its multiple sclerosis treatmentĀ OcrevusĀ and lessons its scientists have learned about the disease at the 7th Joint ECTRIMS-ACTRIMS Meeting in Paris, Oct. 25ā28. The presentations will offer new insights into the therapy's mechanisms, safety and effectivenessĀ in people with the primary progressive and relapsing forms of MS. They will also look at new ways to track MS, including additional biomarker possibilities. MS experts say the joint meeting of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) is one of the largest global congregations of scientists working on the disease. The information Genentech plans to present will demonstrate "the commitment of our scientists and research partners to advance understanding of MS progression through ongoing analyses of the Ocrevus Phase 3 clinical trials,ā Dr. Sandra Horning, the company's chief medical officer and head of its Global Product Development arm, said in a press release. Genentech, which is part of the Roche group, said the 18 presentations will represent the largest body of evidence ever presented on Ocrevus. The discussions will reinforce the therapy's favorable benefit-risk profile, Genentech added. Two presentations will cover new ways that doctors can look for signsĀ of disease activity that can lead to disability. One yardstick is calledĀ progression independent of relapse activity, or PIRA. AnotherĀ is tracking slowly evolving lesions. Genentech researchers came up with the approaches when they analyzed a subgroup of patients in the OPERA I and OPERA II Phase 3 clincal trials, whose aim was to evaluate Ocrevus as a treatment for relapsing MS. The patients' disease progressed even though they had no relapses, researchers said. The team will also discuss how Ocrevus affected these patients' disease. Another presentation will cover long-term follow-up data from an extension of the ORATORIO Phase 3 clinical trial (NCT01194570), which dealt with Ocrevus' ability to treat primary progressive MS. It will Ā look at how well Ocrevus slowed the progression of patients' disability. Updated information on Ocrevusā safety āĀ based on open-label extension studies āĀ will be another component of the presentations. So far, researchers have detected no new safety issues. Genentech will also discuss a new way of using conventional magnetic resonance imaging (MRI) to identify and track slowly evolving lesions. The company's scientists think that tracking the lesions may be a good way to measure chronic disease activity. This would contrast with tracking ordinary MS lesions, which are biomarkers of acute ā as opposed to chronic ā disease activity. In addition to "two new potential markers of underlying disease activity and their impact on disease progression, we hope to bring new tools to the MS community to better understand and manage the disease,ā Horning said. One tool, which Genentech has begun testing in clinical trials, is gathering patient information with sensors connected to a smartphone. Researchers are comparing the information obtained in the FLOODLIGHT study with what physicians record during patient visits. The research team believes the FLOODLIGHT method may beĀ be able to detect subtle changesĀ better. This could make it a better predictor of disease activity and long-term patient outcomes. In addition to the presentations, Genentech will sponsor two symposia at the meeting that will discuss how MS progresses, features of the chronic version of the disease, and the link between inflammation and the progression of MS. The U.S. Food and Drug AdministrationĀ approved Ocrevus in March 2017. Ā
October 11, 2017 News by Patricia Silva, PhD Oryzon to Present Data on Potential Anti-neurodegenerative Therapy at MSParis2017 Spain’sĀ Oryzon GenomicsĀ will offer new data on the preclinical efficacy of ORY-2001, an epigenetic modulator it is developing to treat Ā multiple sclerosis (MS). Its presentation is set for Oct. 26 at MSParis2017, the joint international meeting of the European and Americas Committees for Treatment and Research in Multiple Sclerosis…
October 4, 2017 News by Charles Moore #MSParis2017 – ECTRIMS-ACTRIMS Congress on Latest Research, Treatments Starts Oct. 25 The 7th Joint ECTRIMS-ACTRIMS Meeting, the worldās largest annual international conference devoted to basic and clinical research in multiple sclerosis, will run from Oct. 25 to 28 in Paris ā the city of Jean-Martin Charcot, the “Father of Neurology,” who provided the first detailed description of multiple sclerosis (MS)…
September 7, 2017 News by Jose Marques Lopes, PhD #MSParis2017 – Gilenya Reduces Relapses in Children and Adolescents with MS, Novartis Trial Shows Gilenya decreased relapses in children and adolescents with multiple sclerosis in the phase 3 PARADIGMS trial, according to the therapy's developer, Novartis. The Swiss company will present the trial's results at the 7th Joint ECTRIMS-ACTRIMS meeting, set for Oct. 25-28 in Paris. The study addressed the safety and efficacy of an oral, once-daily dose of Gilenya in 215 MS patients aged 10 to 17. Participants received 0.5 mg or 0.25 mg of Gilenya, according to their body weight, and results were compared with those of intramuscular Avonex (interferon beta-1a given once weekly). The trial ā conducted at 87 sites in 25 countries ā was designed in partnership with the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the International Pediatric Multiple Sclerosis Study Group. Gilenya led to a "clinically meaningful decrease in the number of relapses" over a period of up to two years, compared to Avonex, according to the trial. The safety results of Gilenya matched those observed in previous trials, with adverse events more likely among the Avonex group. Importantly, the PARADIGMS trial is the first-ever randomized, controlled Phase 3 study of a disease-modifying therapy in pediatric MS. No treatment is currently available for children and adolescents with MS. Novartis will now complete a thorough evaluation of the results and later submit Gilenya for approval by regulatory agencies. It will also extend the study to a five-year period.
September 5, 2017 News by Patricia Silva, PhD #MSParis2017 – TG Therapeutics to Discuss Ublituximab’s Effectiveness at ECTRIMSāACTRIMS Meeting in Paris TG Therapeutics will discuss ublituximab's ability to deplete B-cells linked to multiple sclerosis and to reduce inflammatory brain lesions at the 7th Joint ECTRIMSāACTRIMS Meeting in Paris next month. The three presentations will cover preliminary results of a Phase 2 clinical trial of ublituximab's safety and effectiveness as a treatment for relapsing forms of MS, the company said in a press release. The conference will be Oct. 25-28. Dr. Amy E. Lovett-Racke of Ohio State University will discuss ublituximab's ability to decrease B-cells associated with MS after six months of treatment. Ublituximab is an antibody that targets B-cells carrying the CD20 protein on their cell surfaces. These cells are thought to play a role in MS development. Dr. Matilde Inglese of the Icahn School of Medicine at Mount Sinai in New York will discuss ublituximab's ability to decrease study participants' inflammatory brain lesions. And Dr. Edward Fox of Central Texas Neurology Consultants, the trial's principal investigator, will do a poster-session presentation on the study's patient characteristics and preliminary results as a whole, including safety. The ongoing Phase 2 trial is still recruiting patients with relapsing forms of MS. Researchers are randomly assigning participants to receive intravenous infusions of either ublituximab or a placebo. One of the studyās primary goals is to see how well ublituximab depletes B-cells 28 days after the start of treatment. Another primary goal is to see how safe the therapy is, with the measurement being treatment-related adverse events that patients experience over six months. Ublituximabās ability to reduce relapses will be a secondary measure of the trial. Researchers will assess it after 48 weeks of treatment. Fox, who is the director of the Multiple Sclerosis Clinic of Central Texas, and a clinical assistant professor at the University of Texas Medical Branch in Round Rock, made a ublituximab presentation at the 3rd Congress of the European Academy of Neurology in June. It revealed that the therapy nearly depleted B-cells only four weeks after treatment started. Earlier data suggests that ublituximab can be administered in only one hour. Ocrevus, the only approved MS therapy that targets B-cells with CD20, requires 3 1/2 hours. Although the Phase 2 trial is continuing, the data generated so far supports plans for two Phase 3 trials, TG Therapeutics said. They will randomize patients to receive either ublituximab or Aubagio. The trials, which the company hopes to start by the end of September, will be conducted under a Special Protocol Assessment agreement with the U.S. Food and Drug Administration. It allows the FDA to evaluate the design and population size of a trial a company intends to use to seek a drug's regulatory approval. The FDA has refused to approve therapies whose trial design it believed to be flawed. Obtaining a design sign-off before a trial improves the chance of a treatment being approved if it meets the study's objectives.
September 1, 2017 News by Patricia Silva, PhD #MSParis2017 – MediciNova to Share Results of Ibudilast Trial in Progressive MS at October Summit MediciNova will present data from its clinical trial of ibudilast (MN-166) in progressive multiple sclerosis (MS) at the upcoming 7th Joint ECTRIMS – ACTRIMS Meeting in Paris. The European and American Committees for Treatment and Research in Multiple Sclerosis (ECTRIMS and ACTRIMS) selected the presentation “…