Worsening Disability in Absence of Relapses ‘Underestimated’ in MS
A substantial amount of disability worsening happens independently of relapses in people with multiple sclerosis (MS), including those in…
Articles by Marisa Wexler, MS
Roche and UK University Team Up to Test Floodlight App Effectiveness
Roche is teaming up with the University of Plymouth in the U.K. to help develop Floodlight MS, the company’s…
Immune Reaction to Milk Protein May Explain Dairy’s Link to MS
Immune system reaction to casein, a protein in cow’s milk, can trigger an inflammatory neurological disease in mice that’s similar…
#ACTRIMS2022 – Blood NfL Levels May Help Quantify Relapse Severity
Measuring levels of the neurofilament light chain (NfL) protein in blood may be a way to “quantify” relapse severity and…
#ACTRIMS2022 – Cognitive Training Paired With tDCS Aids Patients
Electrically stimulating the brain while doing at-home cognitive training games can help to prevent a decline in cognition for people…
#ACTRIMS2022 – Tolebrutinib More Potent Than Other BTK Blockers
Tolebrutinib, an investigative inhibitor of Bruton’s tyrosine kinase (BTK) being developed by Sanofi to treat all forms of multiple sclerosis…
#ACTRIMS2022 – Algorithm Predicts Relapse Risk Using EHR Data
Using a two-step machine learning strategy, researchers have developed an algorithm to predict the risk of multiple sclerosis (MS)…
#ACTRIMS2022 – Hormone Therapies May Benefit Menopausal MS Patients
Hormonal changes over time — and especially those around menopause — are often associated with disability worsening in multiple…
#ACTRIMS2022 – Ublituximab Eases Brain Lesions Better Than Aubagio
The experimental medication ublituximab significantly reduces the number of new brain lesions with severe nerve cell degeneration in people…
#ACTRIMS2022 – Cortical Lesions Seen to Predict Disability Worsening
A higher burden of lesions in the brain’s cortex is associated with a greater likelihood of disability worsening in…
#ACTRIMS2022 – Spinal Cord Atrophy Predicts ‘Silent Progression’ in Early MS
A faster rate of atrophy in the spinal cord of people in earlier stages of multiple sclerosis (MS) is likely…
#ACTRIMS2022 – Mavenclad Best at Reducing Relapses: Real-world Data
People with multiple sclerosis (MS) who are treated with Mavenclad (cladribine) are less likely to experience a disease…
#ACTRIMS2022 – Iron Rim Lesions Linked to More Severe Disease
Iron rim lesions, or specific regions of chronic inflammation seen on MRI scans of the brain, are associated with greater…
#ACTRIMS2022 – In New Mouse Model, Evobrutinib Shows Efficacy
Researchers developed a new mouse model that more closely captures a specific type of inflammation characteristic of progressive multiple…
#ACTRIMS2022 – Immune System ‘Reset’ by Stem Cell Transplant
Undergoing a stem cell transplant, a procedure that aims to “reset” a person’s immune system, can reduce relapse rates and…
#ACTRIMS2022 – Blocking Fibulin-2 Protein May Increase Remyelination
A matrix protein called fibulin-2, which is increased in multiple sclerosis (MS) lesions, blocks the activity of oligodendrocytes, the…
#ACTRIMS2022 – Paramagnetic Rim Lesions ‘Highly Specific’ Markers of MS
Paramagnetic rim lesions, a specific form of inflammatory damage to the brain, are rarely found in people with disorders other…
#ACTRIMS2022 – Machine Learning Helps Predict Treatment Response in PPMS
Machine learning — using computer algorithms — can be used to identify people with primary progressive multiple sclerosis (PPMS)…
NfL Blood Test May Help Predict MS Activity, Treatment Response
Levels of a protein called neurofilament light chain (NfL) in the blood can be used to predict the risk of…
Review Highlights Substantial Knowledge Gaps in Women’s Health in MS
There has been a marked increase in the amount of research done regarding women’s health in multiple sclerosis (MS)…
Cognitive Problems May Be Due to Myelin’s Loss on Inhibitory Neurons
Myelin is required for certain inhibitory neurons — which help to suppress abnormal activity in the brain — to work…
Physical Activity, Coping Skills Can Help to Ease Anxiety With MS
Getting more physical activity and having effective ways of coping with multiple sclerosis (MS) could help to ease anxiety…
Bacteria-fighting White Blood Cell ‘Traps’ Tied to T-cell Inflammation
Molecular “traps” made by neutrophils, a type of white blood cell, to fight bacteria may contribute to the excessive inflammatory…
Eating Beans, Vegetables May Reduce MS Risk
Eating a lot of green leafy and other vegetables, beans, nuts and berries seems to significantly lower the likelihood of…
Vumerity Added to NHS of Scotland for People With Active RMMS
Note: An earlier version of this story stated the Scottish Medicines Consortium approved Vumerity for RRMS patients in that…
Clinicians Find Pelvic Health Clinic Helpful for Patient Sexual Health
Doctors and nurses involved in the care of people with multiple sclerosis (MS) at a center in Scotland “highly”…
Patients Who Stop Tysabri for Pregnancy at Higher Risk for Relapse
The majority of multiple sclerosis (MS) patients who stop taking Tysabri (natalizumab) before or when they become pregnant…
Self-injectable Therapies Tied to No Disease in 50% of Patients at 2 Years
More than half of multiple sclerosis (MS) patients treated with self-injectable therapies — namely, glatiramer acetate, marketed as Copaxone,…
Combined Data May Predict Person’s Risk of Advancing From CIS to MS
A novel algorithm that combines genetic, environmental, and clinical data could be useful for predicting whether people with a…
Study: DNA Methylation in T-cells Affected by MS and Its Treatments
Multiple sclerosis (MS) is characterized by changes in methylation — a type of chemical modification in the DNA that…