Treatment with medrysone, a glucocorticoid approved in the U.S. as a topical treatment for certain inflammatory eye diseases, improved repair of myelin in a mouse model of demyelination, a new study shows. The results suggest medrysone may be a useful treatment for multiple sclerosis (MS), which is…
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Long-term treatment with Ponvory (ponesimod) safely and effectively reduces the rate of relapses, slows disability worsening, and prevents brain volume decline in adults with relapsing-remitting multiple sclerosis (RRMS). That’s according to eight years of data from patients enrolled in a now-completed Phase 2 clinical trial (NCT01006265) and its…
The protective barrier that prevents cells and large molecules from crossing into the central nervous system (CNS) is known to be unusually “leaky” in multiple sclerosis (MS), but targeting a protein called ARF6 can help to stabilize this barrier, a study in mouse models of MS found. Such a treatment…
Treatment with the experimental B-cell depleting therapy ublituximab significantly outperformed Aubagio (teriflunomide) at reducing relapse rates and the number of lesions in people with relapsing forms of multiple sclerosis (MS), according to updated data from the Phase 3 ULTIMATE clinical trials. The two medications had comparable effects…
An experimental oral therapy called TRE-515 significantly reduced disease severity and the growth of the abnormal immune cells that drive multiple sclerosis (MS) in two mouse models of the disease, a study found. Notably, the efficacy of Trethera Corp.’s potential treatment, administered either in a preventive or therapeutic…
How much a country spends on healthcare is associated with the prevalence of multiple sclerosis (MS), with higher spending nations seeing a greater number of MS cases, a study found. MS cases might be underestimated in low-income nations that put less money into the healthcare system, resulting in reduced…
Biosimilar, or “follow-on,” forms of disease-modifying therapies (DMTs) that have been approved in a highly regulated area can be considered as safe and effective as their reference medications, according to multiple sclerosis (MS) experts. A biosimilar is a medication that’s highly similar to an existing biological medication in…
People who had infectious mononucleosis — a contagious disease for which the Epstein-Barr virus (EBV) is the leading cause — had a higher incidence of multiple sclerosis (MS) in the 10 years following diagnosis compared with individuals not diagnosed with the virus, a study found. This link was particularly…
Aquatic exercise therapy can help to ease fatigue and improve balance in people with multiple sclerosis (MS), without notable side effects, according to a review of published studies. These findings have important implications for MS patients, as fatigue is among the main symptoms of the disease and…
A data-driven algorithm may be useful for defining the sometimes unclear transition from relapsing-remitting (RRMS) to secondary progressive (SPMS) forms of multiple sclerosis, a study found. The study, “Towards a validated definition of the clinical transition to secondary progressive multiple sclerosis: A study from the Italian MS Register,”…
The newest recipients of the MS Australia incubator grants will seek novel ways to prevent and treat multiple sclerosis (MS) and explore the prevalence and incidence of the neurodegenerative disorder in different parts of the country. One scientist will use the funding to explore disease risk factors — and…
Women with multiple sclerosis (MS) are not at a higher risk of their babies having growth deficits during pregnancy or after birth than individuals without the disease, a study suggests. Yet, the data showed women with MS are significantly more likely to deliver their babies by cesarean section (C-section)…
Worldwide, about 22 in every 100,000 people live with secondary progressive multiple sclerosis (SPMS), a review study analyzing data across various countries reported. Its researchers found substantial variability in SPMS rates country-by-country, with countries closer to the poles generally reporting higher prevalence than those near the equator. Rates also…
Baclofen, an approved therapy for spasticity in multiple sclerosis (MS) patients, promoted the repair of myelin — the protective sheath around nerve fibers that’s progressively lost in MS — in a mouse model of the disease, a study showed. These findings suggest baclofen — sold as oral tablets,…
The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to Trethera Corporation’s experimental oral therapy TRE-515 for demyelinating optic neuritis, an eye condition that may progress to multiple sclerosis (MS) or occur during the disease course. The first-in-class therapy is expected to lessen the inflammation…
Publicity in national news outlets and an online self-screening questionnaire helped improve recruitment for a clinical trial in secondary progressive multiple sclerosis (SPMS), a new study highlights. “We have described our experience of recruiting participants with SPMS into two large RCTs [randomized clinical trials] in order to identify areas…
The risk of developing multiple sclerosis (MS) is lower in women with a history of pregnancy and is not affected by the use of oral contraceptives, according to a recent meta-analysis of four published studies. However, the four studies, conducted in the U.S. and Iran, showed considerable variability in…
A machine learning approach based on eye scans was employed by researchers to diagnose multiple sclerosis (MS) in children with up to 80% accuracy. Optical coherence tomography (OCT) scans also provided enough data to diagnose other demyelinating diseases with 75% accuracy. OCT is an imaging tool that uses…
Researchers have discovered how interferon-beta, a common treatment for multiple sclerosis (MS), may be effective for people with the disease. Specifically, they found that red blood cells from MS patients have an unusually high ability to bind molecules that contribute to disease-related impairments in neuronal health and myelin repair,…
CNM-Au8, Clene Nanomedicine’s experimental oral therapy, safely and effectively improves vision and neurological function in adults with stable relapsing-remitting multiple sclerosis (RRMS) and disease-related visual impairment. Those are the findings of the VISIONARY-MS Phase 2 clinical trial (NCT03536559), a proof-of-concept study that investigated CNM-Au8 in people with…
Researchers have identified early factors that can affect the trajectory of a patient’s long-term health-related quality of life (HRQoL) after a multiple sclerosis diagnosis. These factors include older age, worse physical impairment, and more severe fatigue at diagnosis, which were predictive of worse long-term physical HRQoL. In addition,…
People with multiple sclerosis (MS) who responded to cognitive rehabilitation showed healthier connections between certain brain regions on functional MRI scans than did MS patients who did not respond to the rehab program, a new study reports. These results indicate that certain brain regions need to be working…
The first symptoms of relapsing-remitting multiple sclerosis (RRMS) have been appearing increasingly later in life, according to a Spanish study covering nearly five decades. From the 1970s through the 2010s, the average age at disease onset rose by more than 10 years in both men and women, its researchers…
In its inaugural issue, a publication from The Gerontological Society of America provides information about recognizing and managing pseudobulbar affect — uncontrolled outbursts of crying or laughing that the authors say are one of the most “underrecognized and undertreated” symptoms of multiple sclerosis (MS) and other neurological conditions. The…
Virtual reality exergames — immersive video games whose play involves physical exercise — may be better than conventional exercise at easing certain symptoms of multiple sclerosis (MS), such as balance and upper limb function, a review of published studies suggested. However, differences among the evaluated studies — in matters…
Men with multiple sclerosis (MS) show differences in health-related behaviors based on how much they value certain masculine ideals, according to a new study that suggests possible negative effects of masculinity in terms of seeking medical care. Results from the study — which specifically focused on white males in…
People with multiple sclerosis (MS) who are on therapies that deplete antibody-producing B-cells can mount an effective T-cell immune response to COVID-19 vaccination, a new study shows. The findings suggest that the vaccines strongly activate other parts of the immune system that are helpful in fighting the virus,…
Robotic-assisted gait training (RAGT) may be the most effective form of physical exercise for improving mobility among people with severe multiple sclerosis (MS), according to a recent review study. Other exercise types, such as conventional walking, treadmill training, and yoga, may also be feasible and effective, however, the researchers…
Pasithea Therapeutics investigational multiple sclerosis vaccine, PAS002, effectively delayed disease onset and reduced disease severity in a mouse model of the neurodegenerative condition, according to data from a preclinical study. The vaccine, which is designed to promote immune tolerance to a specific myelin protein, also reduced the severity…
After a relapse involving optic neuritis, or inflammation in the nerves connecting the eyes and brain, measurements of retinal thinning may predict the likelihood of full recovery from future relapses in people with multiple sclerosis (MS), a study suggests. The measurement could identify subclinical nerve cell damage that remains…