News

Neubie, a neuromuscular electrical stimulation device developed by NeuFit, led to measurable improvements in function and strength in the six multiple sclerosis (MS) patients who participated in a three-day physical therapy bootcamp, the company announced in a press release. The Neubie device is part of the NeuFit…

Donations to the Multiple Sclerosis Society of Canada will double in value for this year’s Giving Tuesday on Nov. 30, meaning each donation will provide three times the support for Canadians with multiple sclerosis (MS) . An anonymous donor will double match each donation made on Giving Tuesday,…

Mynd Diagnostics is launching a clinical study to test the ability of a blood biomarker, which the company coined Mynd anti-inflammatory peptide (MAP), to help in the diagnosis and monitoring of multiple sclerosis (MS). Starting in the first quarter of 2022, the company will collect blood samples from diagnosed patients…

Immunic Therapeutics has enrolled the first participant in its Phase 3 ENSURE clinical trial program, which is testing the company’s investigational treatment IMU-838 (vidofludimus calcium) in people with relapsing-remitting multiple sclerosis (RRMS). “Enrollment of the first patient in ENSURE … marks an important inflection point for Immunic as we…

ImStem Biotechnology announced that the first patient in its Phase 1 clinical trial for IMS001, an investigational treatment for multiple sclerosis (MS), has been dosed at the Shepherd Center in Atlanta. The trial (NCT04956744) is recruiting participants with an MS diagnosis ages 18 to 65. More information…

Patients with autoimmune diseases, including multiple sclerosis (MS), are uncertain about how to protect themselves against COVID-19, especially with regards to booster shots of the vaccine. According to a national survey by the nonprofit Alliance for Patient Access, these patients are confused due to conflicting information from the…

Inconsistently switching between hands for most common manual activities — or naturally choosing the left rather than the right hand — may be associated with more severe multiple sclerosis (MS), either in the form of younger age at diagnosis or progressive type, particularly in women, a small study suggests. These…

Side effects upon receiving the COVID-19 vaccine in people with multiple sclerosis (MS) are similar to those reported in the general population, and patients on certain disease-modifying therapies are less likely to have vaccine reactions, a survey-based study found. The findings provide “a reassuring picture” for those who feel hesitant about…

Patients with relapsing multiple sclerosis (MS) treated with subcutaneous cladribine saw limited disease progression over a follow-up period of up to 20 years, especially with increased cumulative dosing, according to a recent study. Subcutaneous (SC) cladribine is administered as an under-the-skin injection. It is a formulation different from…

The Multiple Sclerosis Society of Canada is urging that all provinces and territories in Canada offer COVID-19 booster vaccines to at-risk populations, including people who are moderately to severely immunocompromised and multiple sclerosis (MS) patients. In letters sent earlier this month, in collaboration with 11 other health charities, the…

Cholesterol made by neurons is crucial for repairing long-term damage to the myelin sheath, the fatty coating around nerve fibers that is damaged in multiple sclerosis (MS), according to a new report based on experiments done on mice. The finding suggests that increasing neuronal cholesterol synthesis may be helpful…

The development of Delpor‘s DLP-208 implant for the treatment of moderate-to-severe spasticity, a symptom that commonly affects people with multiple sclerosis (MS), has been boosted by a National Institutes of Health (NIH) grant. The $2.5 million grant will help the company advance DLP-208 into clinical testing, which…

Long-term use of a high-dose nutritional supplement containing specific antioxidant vitamins and omega-3 and omega-6 fatty acids may boost walking performance and other measures of functional capacity in people with relapsing-remitting multiple sclerosis (RRMS), a new study found. The study, “The Effects of Specific Omega-3 and…

The oral medication Vumerity (diroximel fumarate) has been approved by the European Commission to treat adults with relapsing-remitting multiple sclerosis (RRMS). “This approval is a significant step forward in improving treatment adherence for people living with relapsing MS, which can make a meaningful difference on treatment…

The number of lesions affecting the cerebellum — a brain region responsible for coordinating voluntary movements and motor skills such as balance, coordination, and posture — predicts manual dexterity getting worse in people with relapsing-remitting multiple sclerosis (RRMS), according to a retrospective analysis. The study, “Cerebellar pathology and…

Most relapsing-remitting multiple sclerosis (RRMS) patients switching to Ocrevus (ocrelizumab) following suboptimal responses to other disease-modifying therapies (DMTs) show no evidence of disease activity, according to final two-year data from the European-based CASTING Phase 3b trial. These clinical benefits, which entail no relapses or disease progression and no…

People in a Neural Sleeve gait study were reported to show an “average improvement” of 143% in foot drop, a common symptom of multiple sclerosis (MS) and other conditions that hinder mobility, its developer, Cionic, reports. The wearable “bionic” device — which analyzes, predicts,…

Having at least one pregnancy may lower disability scores in women with multiple sclerosis (MS), but breastfeeding for longer than six months may worsen damage to the brain, an observational study in patients has found. Findings support the need for careful pregnancy planning, counseling, and treatment management to ensure…

Sanofi Genzyme has extended its collaboration with Koneksa to bring digital measures into its Phase 3 trials of tolebrutinib, an investigational therapy for relapsing and progressive forms of multiple sclerosis (MS). Through this joint effort, Koneksa’s digital biomarkers were applied to clinical trials of Parkinson’s…

The Scottish Medicines Consortium (SMC) has recommended that Ponvory (ponesimod) be offered through the National Health Service (NHS) Scotland to people with active, relapsing forms of multiple sclerosis (MS). The decision means that the oral therapy will be available at low or no cost to patients with clinically isolated syndrome (CIS),…

The Multiple Sclerosis Society of Canada (MSSC) has partnered with the National Multiple Sclerosis Society (NMSS) to support a Canadian-led study investigating the earliest predictors of multiple sclerosis (MS) during the so-called prodromal period across diverse groups. A prodrome is a set of signs or symptoms that…

Measuring levels of the protein serum neurofilament light chain (NfL) can help to identify people with relapsing-remitting multiple sclerosis (RRMS) at higher risk of relapse-free disability progression or conversion to secondary-progressive disease, according to a study from Germany. The study, “NfL predicts relapse-free progression in a longitudinal…

Patients’ underestimation of their own disease and the cost and side effects of disease-modifying therapies (DMTs) are among the main causes of delayed treatment initiation and non-adherence in multiple sclerosis (MS) patients, according to a report from OptimizeRx. These findings help uncover areas for improvement, which the health…

The multiple sclerosis (MS) treatment Tecfidera (dimethyl fumarate) triggers immune cell death by interacting with a protein called Keap-1, a new study reveals. The study, “Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera,” was published in Nature Communications. Tecfidera is widely…

Ocrevus (ocrelizumab) continues to be the most commonly prescribed therapy for progressive forms of multiple sclerosis (MS), including primary progressive MS (PPMS) and secondary progressive MS (SPMS), according to an analysis from the market intelligence firm Spherix Global Insights. However, other therapies are “gaining traction” among…

It’s been a decade since the opening of the UK MS Register, which sought to gain a better understanding of how multiple sclerosis (MS) affects patients’ everyday lives, with a goal, according to its website, toward fueling campaigns for “fair, relevant policy and improved health care.” Now, the…

Among people with nervous system damage indicative of multiple sclerosis (MS), but who don’t yet have the disease — a condition known as radiologically isolated syndrome or RIS — the risk of progressing to full-fledged MS is higher for those who are younger, have spinal cord lesions, and have…

Using robotic devices during gait training can improve walking abilities in people with multiple sclerosis (MS), particularly among those with severe disability, a review of 17 studies has found. However, the benefits lasted only a few months, suggesting that patients need regular training to maintain the improvements. The study,…

A single dose of NVG-291, a potential nerve repair therapy for multiple sclerosis (MS), was safe and well-tolerated among healthy volunteers in a Phase 1 safety trial, and was found to have favorable pharmacological properties, new data show. Given the positive results thus far, a safety committee supervising…

Extracellular vesicles or EVs — tiny sacs of material excreted by cells — that have been coated with protein receptors were found to safely reduce disease progression in a mouse model of multiple sclerosis (MS). Researchers at the Karolinska Institutet, in Sweden, coated these vesicles with receptors that block pro-inflammatory…