blood brain barrier

June 17, 2019June 17, 2019

Human Blood-brain Barrier in a Chip, Created in the Lab, May Help Design New Therapies, Study Shows

News

By tweaking stem cells in a laboratory, researchers were able to generate a model of the human blood-brain barrier (BBB) in a chip. The BBB is a highly selective ... Read more

March 5, 2019March 5, 2019

#ACTRIMS2019 – Bacterial Epsilon Toxin Found in MS Patients Triggers MS Disease Features in Rodents

News

The levels of epsilon toxin are increased in multiple sclerosis (MS) patients, and its presence in laboratory rodents replicated some aspects of disease activity, according to data presented at the ... Read more

December 17, 2018December 17, 2018

Inactivation of S1PR2 Protein Shows Therapeutic Potential in MS Mouse Model, Study Reports

News

Inactivation of S1PR2, a cell surface protein, helps improve clinical disability and reduce demyelination in a mouse model of experimental autoimmune encephalitis (EAE), a condition similar to multiple sclerosis (MS) ... Read more

November 27, 2018December 4, 2018

Homotaurine Compound May Be New Class of Treatment for MS, Mouse Study Suggests

News

Homotaurine, a compound proven safe for humans in long-term clinical trials, has eased autoimmune responses, brain inflammation, and multiple sclerosis-like symptoms in a mouse model of the disease, a ... Read more

October 22, 2018October 22, 2018

Antibody Targeting Clotting Factor Seen to Lessen Inflammation, Nerve Cell Damage in MS Model

News

An antibody that blocks a blood-clotting factor from leaking into the brain was seen to lessen neuroinflammation and nerve cell damage in mouse models of multiple sclerosis (MS) and ... Read more

June 6, 2018June 6, 2018

#CMSC2018 — Inhibiting Oxidative Stress Enzyme Promotes Resealing of Blood-Brain Barrier in MS Mouse Model

News

Inhibiting an oxidative stress enzyme called myeloperoxidase protects the blood-brain barrier in a mouse model of multiple sclerosis (MS), limiting the migration of immune cells and halting their attack ... Read more

March 13, 2018March 13, 2018

High Levels of Protein Can Disrupt Blood-Brain Barrier in MS, Study Finds

News

High levels of a protein called calnexin in the brain may disrupt the blood-brain barrier of patients with multiple sclerosis, a Canadian study suggests. The finding could lead to ... Read more

March 8, 2018March 15, 2018

Increase in Blood-Brain Barrier Protein May Protect Against MS, Study Finds

News

One way the body may protect itself from nerve cell inflammation is to have cells in the blood-brain barrier increase their production of a protein that keeps immune cells ... Read more

November 28, 2017November 30, 2017

Immune Cells Use 2 Entry Points to Overcome Blood-brain Barrier and Attack Myelin in MS Mice

News

Immune cells that destroy myelin in multiple sclerosis access the brain and spinal cord via two different routes, a new mouse study shows. This suggests that therapies which target ... Read more

November 8, 2017November 8, 2017

Blocking CXCR7 Receptor of Mature Monocytes Could Be New Therapeutic Strategy in MS

News

The CXCR7 receptor present on mature monocytes — a type of white blood cell — may be a therapeutic target to alleviate the inflammation seen in multiple sclerosis (MS) and ... Read more

August 23, 2017August 24, 2017

Nortis Awarded $688K Grant from NIH to Develop ‘Living’ Model of Blood-Brain Barrier for Research

News

Nortis, a Seattle-based biotech company, has received a $688,000 grant by the National Institutes of Health to create a living, 3-D model of the human blood-brain barrier that will ... Read more

March 20, 2017March 20, 2017

EBI2 Receptor Facilitates T-cell Invasion of Brain in MS, Animal Study Shows

News

Scientists have identified a receptor that promotes the influx of damaging immune T-cells into the brain of a mouse model of human multiple sclerosis (MS). The study, “EBI2 is ... Read more

February 9, 2017February 8, 2017

How the Blood Brain Barrier May Thwart MS Progression

Columns, Faith of the Mustard Seed - a Column by Debi Wilson

Lately, I have been reading more and more about the potential connection between the blood brain barrier and multiple sclerosis. I have been researching the blood brain barrier (BBB) ... Read more

December 2, 2016December 19, 2016

Fat Bubbles and Ultrasound May Offer Way of Getting MS Therapies Directly to Brain

News

A new ways of delivering drug therapies directly to the brain, overcoming the limitation imposed by the blood-brain barrier (a permeable barrier that protects the brain), has been discovered. The ... Read more

September 16, 2016September 16, 2016

#ECTRIMS2016 – Protein Seen as New Target in Preventing Brain Inflammation in MS

News

Researchers found that blocking a protein, known as integrin alpha 8, may work to prevent inflammation in the central nervous system of patients with multiple sclerosis (MS). The results were revealed in an ... Read more

July 22, 2016July 22, 2016

Antibody Created in Lab Treats MS in Mice by Preventing Immune Cells from Piercing Blood-Brain Barrier

News

Building on work began in stroke studies and applying it to multiple sclerosis, researchers in France report that an antibody they developed kept the blood-brain barrier intact in cellular ... Read more

November 4, 2015November 5, 2015

New Multiple Sclerosis Study Reveals Protein’s Role in Disease Activation

News

In a new study entitled “Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation,” a team of scientists discovered the mechanism by which autoreactive T cells ... Read more

October 7, 2015October 7, 2015

Good Cholesterol Helps Prevent Brain Lesion Formation in Multiple Sclerosis

News

A number of studies have previously suggested a negative effect of high cholesterol levels on the development of brain lesions in patients with multiple sclerosis (MS), however, little is ... Read more

September 2, 2015September 2, 2015

Obstructive Sleep Apnea Found To Contribute to Blood–Brain Barrier Breakdown Experienced By MS Patients

Multiple Sclerosis News, News

In a recent study published in the Journal of Neuroimaging, a team of researchers from the UCLA have reported the first evidence that obstructive sleep apnea contributes to a ... Read more

May 21, 2015May 21, 2015

New Potential Therapeutic Strategy to Halt Disease Progression in Multiple Sclerosis Developed

News

A new study recently published in the journal Annals of Neurology revealed a potential new therapeutic strategy to halt multiple sclerosis (MS) disease progression. The study is entitled “Melanoma ... Read more