March 26, 2024 News by Marisa Wexler, MS Advancing age affects Tregs’ ability to promote myelin repair: Study While regulatory T-cells (Tregs) are able to promote remyelination ā the repair of the myelin sheath that’s damaged in multiple sclerosis (MS) ā this ability declines significantly with age, a new study shows. Based on the findings, researchers have identified molecular targets that may boost the myelin-repairing features…
October 2, 2023 News by Marisa Wexler, MS Viral protein blocks myelin repair, activates inflammation in models The expression of a viral protein known as W-Env leads to the inflammatory activation of brain cells and impairs myelin repair in mouse models of multiple sclerosis (MS), a study reports. “Our study shows that the presence of W-Env in the brains of MS patients appears to generate a…
September 8, 2023 News by Marisa Wexler, MS Study finds new molecular mechanism involved in myelin repair A protein called Daam2 helps to regulate the activity of cells in the brain that make myelin, the fatty covering around nerve fibers that’s damaged in multiple sclerosis (MS), a new study shows. By uncovering how that protein functions in the brain to boost myelin repair, researchers have discovered…
September 5, 2023 News by Margarida Maia, PhD MS Australia awards incubator grants to four research projects Four researchers working in multiple sclerosis (MS) were awarded incubator grants in MS Australiaās latest funding round, which theyāll use to kickstart projects designed to better understand the progressive neurodegenerative disease. Worth a total of AU$92,565, or roughly $60,000, this round of incubator grants provides seed funding…
August 28, 2023 News by Marisa Wexler, MS Sugar molecule found to promote myelin repair in cell model Treatment with polysialic acid, a sugar molecule naturally made in the body, may be a promising approach to boost myelin repair in people with multiple sclerosis (MS), according to a new study in lab-grown brain samples. Findings show that the molecule increased myelin repair, or remyelination, in the cell…
June 22, 2023 News by Marisa Wexler, MS Pregnancy hormone estriol promotes myelin repair in MS mice Treatment with estriol, a hormone that’s produced during pregnancy, reduced disease severity and promoted myelin repair in the cortex ā a key brain region affected in multiple sclerosis (MS) ā in a mouse model of the disease. Those are the main findings of the study, āNeuroprotection in cerebral…
June 16, 2023 News by Steve Bryson, PhD MRI method detects myelin repair with over-the-counter antihistamine The over-the-counter antihistamine clemastine has demonstrated an ability to repair myelin, the protective coating on nerve fibers that’s damaged in multiple sclerosis (MS), according to an analysis of MRI data from the ReBUILD clinical trial. The changes in myelin were examined with a noninvasive MRI method that more…
October 27, 2022 News by Lindsey Shapiro, PhD #ECTRIMS2022 ā Poor Myelin Repair Offers Clues in Disease Progression Remyelination, or regeneration of the myelin sheath that’s progressively damaged and lost in multiple sclerosis (MS), may be less effective for those who develop MS later in life, new research suggests. People with late-onset MS (LOMS) whose disease appears after age 50 have significantly fewer oligodendrocytes ā the…
September 30, 2022 News by Marisa Wexler, MS Quick MRI Method May Reliably Detect Myelin Repair in People A quick MRI-based method called SyMRI may be useful in future clinical trials to test experimental myelin-repairing therapies in diseases like multiple sclerosis (MS), a new study shows. The study, “Quantification of individual remyelination during short-term disease course by synthetic magnetic resonance imaging,” was published inĀ Brain…
August 31, 2022 News by Marisa Wexler, MS Approved Corticosteroid Medrysone Prompts Myelin Repair in Mice Treatment with medrysone, a glucocorticoid approved in the U.S. as a topical treatment for certain inflammatory eye diseases, improved repair of myelin in a mouse model of demyelination, a new study shows. The results suggest medrysone may be a useful treatment for multiple sclerosis (MS), which is…
August 22, 2022 News by Marta Figueiredo, PhD MS Spasticity Therapy Baclofen Helps to Repair Myelin: Early Study Baclofen, an approved therapy for spasticity in multiple sclerosis (MS) patients, promoted the repair of myelin ā the protective sheath around nerve fibers that’s progressively lost in MS ā in a mouse model of the disease, a study showed. These findings suggest baclofen ā sold as oral tablets,…
August 18, 2022 News by Marta Figueiredo, PhD Study Uncovers How Interferon-beta May Be Helping to Treat MS Researchers have discovered how interferon-beta, a common treatment for multiple sclerosis (MS), may be effective for people with the disease. Specifically, they found that red blood cells from MS patients have an unusually high ability to bind molecules that contribute to disease-related impairments in neuronal health and myelin repair,…
July 25, 2022 News by Marisa Wexler, MS Heart Medication Digoxin Helps With Remyelination in Early Study Digoxin, an approved medication for certain heart conditions, promoted the repair of myelinĀ ā the protective sheath around nerve fibers that is progressively lost in multiple sclerosis ā in mouse models of the disease, a study reports. Combining digoxin with an experimental immune-modulating therapy was more effective at promoting myelin…
July 21, 2022 News by Marisa Wexler, MS Semi-synthetic Compound Promotes Myelin Repair in MS Mice A man-made molecule derived from a naturally occurring amino acid was able to promote the repair of the myelin sheathĀ ā a fatty coating around nerve fibers that is damaged in multiple sclerosisĀ ā in a mouse model of the disease, a new study reports. “These findings suggest that ……
June 14, 2022 News by Marta Figueiredo, PhD Find Therapeutics, SATT Conectus Team to Develop New MS Therapy Find Therapeutics and SATT Conectus have joined forces to develop a promising therapy for multiple sclerosis (MS) and optic neuritis based on a new class of compounds that shows the potential to regenerate myelin. Myelin is the fatty protective sheath around nerve fibers that’s progressively lost…
May 11, 2022 News by Marisa Wexler, MS Treatment With XPro1595 Promotes Remyelination in Mouse Model The experimental therapy XPro1595 was found to promote remyelination ā the repair of the myelin sheath ā in a mouse model of myelin loss, new data show. Myelin, the fatty covering that helps nerve fibers send electrical signals, is damaged by the immune system inĀ …
March 30, 2022 News by Marta Figueiredo, PhD National MS Society Details Steps to Achieving Pathways to Cures The National Multiple Sclerosis Society (NMSS) has detailed its Pathways to Cures Roadmap and potential ways of addressing gaps and advancing each of the pathways, with a final goal of finding a cure for multiple sclerosis (MS) in all its forms. Details were in the report, ā…
March 29, 2022 News by Lindsey Shapiro, PhD Trial Cleared for PIPE-307, Potential RRMS Myelin Restoration Therapy The U.S. Food and Drug Administration (FDA) has cleared a Phase 1b/2a trial of PIPE-307, Pipeline Therapeutics‘ investigational myelin-restoring treatment, in people with relapsing-remitting multiple sclerosis (RRMS). The trial will enroll about 45 RRMS patients from multiple U.S. sites who will be randomized to receive either three months…
March 14, 2022 News by Margarida Maia, PhD PIPE-307, Aiming to Restore Myelin, Found Safe in Phase 1 Trial PIPE-307, an investigational myelin-restoring medication being developed by Pipeline Therapeutics for the treatment of multiple sclerosis (MS), appears to be safe and well tolerated in healthy adults. The results are from a Phase 1 clinical trial (NCT04725175) that evaluated the safety and tolerability of PIPE-307 in 70…
February 18, 2022 Columns by John Connor The Supplements of Mice and Men Roll up, roll up, for all the fun of the fare! I swallow an awful lot of supplements. Have I also swallowed the barkers’ patter? I donāt think so. But Iām more than aware that if something works on mice, then the chances of it working on me are likely…
February 16, 2022 News by Steve Bryson, PhD Newly Created Cells Better at Repairing Myelin in Preclinical Study Therapeutics designed to produce new oligodendrocytes ā the cells responsible for the protective myelin sheath that is damaged in multiple sclerosis (MS) ā might be the most effective approach for disorders such as MS, according to a study conducted in a fish model. That’s because oligodendrocytes that survive being…
February 9, 2022 by BioNews Staff Expert Voices: Current state of MS treatments and cure research In this installment of our āExpert Voicesā series, Multiple Sclerosis News Today asked Tim Coetzee, PhD, some of your questions related to the current state of multiple sclerosis (MS) treatment and cure research. Coetzee serves as the National MS Societyās chief advocacy, services, and science officer. In this capacity, he…
October 4, 2021 News by Marisa Wexler, MS Study Finds Myc Gene Can Boost Efficiency of Myelin-repairing Cells Increasing the activity of a gene called Myc can make oligodendrocyte precursor cells, or the cells that repair myelin, more efficient ā “ground-breaking research” that could have implications for advancing MS treatments, according to a new study by Cambridge researchers. The study, “Myc determines the functional age…
September 27, 2021 News by Marisa Wexler, MS Mesenchymal Stem Cells Show Promise in Preclinical Studies of MS The therapeutic administration of mesenchymal stem cells can improve functional abilities and promote the restoration of lost myelin in rodent models of multiple sclerosis (MS), according to a new analysis of published studies. The findings highlight the potential of these stem cells, but also point to a need for…
August 30, 2021 Columns by Ed Tobias MS News That Caught My Eye Last Week: Ocrevus, Myelin Repair, Early MS Problems, Black MS Experience Summit Ocrevus Reduces MS Relapse Risk, But Linked to More Hospitalizations As you can see from the first two paragraphs of this story, these hospitalizations occurred most frequently in older people with MS. Yet, as these researchers point out, the criteria for selecting the people who participated in Ocrevus’ clinical…
August 27, 2021 News by Marta Figueiredo, PhD Way Seen to Counter Blood-clotting Molecule That Blocks Myelin Repair Blocking a particular receptor protein of the BMP signaling pathway effectively promoted the maturation of myelin-producing cells and myelin repair in two mouse models of multiple sclerosis (MS), a study showed. Notably, these benefits, observed even after disease onset, took place in the presence of fibrinogen, a blood clotting…
June 21, 2021 Columns by Ed Tobias MS News That Caught My Eye Last Week: Myelin Repair, Early DMT Use, Online Physical Therapy, At-home Exercise Scientists Discover Enzyme Needed for Activating Myelin Repair Here’s encouraging news for those interested in remyelination ā and who isn’t interested in repairing our frayed MS nerves? Yes, it’s only a mouse study, but maybe it’s the starting point for finding a way to use a particular enzyme to…
June 14, 2021 News by Steve Bryson, PhD Scientists Discover Enzyme Needed for Activating Myelin Repair The enzyme TET1, which is progressively lost with age, is essential to activate genes needed to repair myelin ā the sheath around nerve cells that is damaged in people with multiple sclerosis (MS) ā a study in mice has found. The…
April 2, 2021 News by Marta Figueiredo, PhD Protecting Myelin-producing Cells From Inflammation May Be Key to Treating MS Prolonging a cellular defense mechanism shown to restore myelin ā the protective sheath around nerve cell fibers that is lost in multiple sclerosis (MS) ā may be key to treating the neurodegenerative disease, a study in MS mouse models suggests. That defense mechanism, called integrated stress response (ISR), helps…
February 23, 2021 News by Diana Campelo Delgado MS Society in UK Commits to Raising $5.2M for Research The MS Society in the U.K. is hoping to raise Ā£3.7 million ($5.2 million) to fund research aimed at developing new treatments for multiple sclerosis (MS). The funds will support research at the Societyās Centers of Excellence in Edinburgh and CambridgeĀ over five years. āOur top priority…