remyelination therapy

Adult myelin-making cells display unique marker affecting activity

A specific epigenetic marker, or a chemical modification in DNA that alters gene activity, may explain why adult oligodendrocyte progenitor cells respond differently to therapies aiming to restore myelin than their neonatal counterparts, a study reports. The modification, called a lysine eight acetylation on histone H4, helps to regulate…

PIPE-307 shows potential to repair myelin in MS mouse model

PIPE-307, an experimental oral therapy that’s currently in Phase 2 testing for relapsing-remitting multiple sclerosis (RRMS), was shown to promote myelin repair in a mouse model of multiple sclerosis (MS). The preclinical findings were published in PNAS, in the study “Targeting the muscarinic M1 receptor…

Frequency Names Advisory Board to Guide Remyelination Work for MS

Frequency Therapeutics has established a clinical advisory board, with experts across neuroscience fields, to help guide its small molecule treatment candidate for remyelination inĀ multiple sclerosis (MS) into clinical testing. The company is planning to initiate a first trial of the molecule, designed to boost remyelination ā€” the…

Heart Medication Digoxin Helps With Remyelination in Early Study

Digoxin, an approved medication for certain heart conditions, promoted the repair of myelinĀ ā€” the protective sheath around nerve fibers that is progressively lost in multiple sclerosis ā€” in mouse models of the disease, a study reports. Combining digoxin with an experimental immune-modulating therapy was more effective at promoting myelin…

Need to Know: What Is Remyelination?

Editor’s note: “Need to Know” is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum. This week’s question is inspired by the forum topicĀ “New MS Therapy Company to Focus on Rejuvenating Coating…

This Is What Excites Me About Remyelination Therapy Research

RemyelinationĀ therapies are on the horizon as an innovative multiple sclerosis (MS) treatment, according to my neurologist. These therapies have been on my radar the last few years, but to hear my neurologist say they could soon be a reality makes me hopeful of the possibilities. To offer a…