RRMS

A Phase 4 observational study called ENABLE is enrolling adults with relapsing forms of multiple sclerosis (MS) across the U.S. to better understand the safety, tolerability, and efficacy of Briumvi (ublituximab-xiiy) in the real world. At least 500 patients are expected to enter ENABLE (NCT06433752) at some…

I remember the day of my relapsing-remitting multiple sclerosis diagnosis, when I didn’t understand the weight of what I’d been told. I was only 17 years old and didn’t know what questions to ask, what the future held, or what I should’ve felt after hearing those words. Aside from feeling…

People of Asian descent tend to be younger than white people when they first exhibit symptoms of multiple sclerosis (MS), a U.S. study reports. Asians also tended to be younger at the time of their diagnosis. No differences were found in demographics or disease characteristics between Asian patients…

No added benefit was found in increasing the dose of Genentech’s Ocrevus (ocrelizumab) — to two to three times the currently approved 600 mg dose — in slowing disability progression in adults with relapsing multiple sclerosis (MS), according to new data from a Phase 3 clinical study. The…

I knew that starting my college journey in a a different city, less than a year after receiving my relapsing-remitting multiple sclerosis (RRMS) diagnosis, would be challenging because I didn’t fully understand what was happening in my body. Even though my college, the University of Texas at Austin,…

A high dose cholecalciferol, a form of vitamin D, significantly reduced the risk of further disease activity in people with clinically isolated syndrome (CIS), published findings from a Phase 3 trial show. Vitamin D was similarly effective for reducing disease activity among a subgroup of participants who would…

Ross smiles for a photo. (Photos courtesy of Ross) Day 21 of 31 This is Ross’ story: I was diagnosed with relapsing-remitting multiple sclerosis (RRMS) in 2007 when I was a senior in college. I had been very sick with vertigo and gastrointestinal issues for a year…

Nanette Lai locks eyes with her chihuahua Fanny. Lai says mutual gazing between humans and dogs can cause synchronization in areas of the brain. (Photos courtesy of Nanette Lai) Day 12 of 31 This is Nanette Lai’s story: My name is Nanette, and I have lived with relapsing-remitting…

Disability progression independent of relapse activity, or PIRA, in the earliest stages of relapsing-remitting multiple sclerosis (RRMS) is associated with worsening quality of life, a study in Sweden shows. PIRA is a form of sustained disability worsening that occurs in the absence of multiple sclerosis (MS) relapses. While…

Using a simple algorithm to recommend highly effective disease-modifying therapies (DMTs) for people with multiple sclerosis (MS) can help make treatment fairer for all patients, and level inequalities otherwise defined by race or ethnicity, a new study by U.S. researchers suggests. Indeed, use of the algorithm over a…

People with multiple sclerosis (MS) who switch from a high- to a moderate-efficacy disease-modifying therapy (DMT) increase their risk of disease activity, especially younger adults and those having inflammatory disease activity before a switch, a study finds. Knowing these factors “can help guide future studies on deescalation,” researchers…

People with multiple sclerosis (MS) who eat more fish are significantly less likely to see confirmed disability progression and the greater the intake, the lower the progression risk, a study in Sweden finds. The dietary habits of patients were assessed at the time of their diagnosis and disability progression…

Note: This study was updated March 3, 2025, to correct that a ketogenic diet is a low-carbohydrate, high-fat diet. Eating a version of the low-carbohydrate, high-fat ketogenic diet for six months led to an anti-inflammatory shift in immune cell populations among people with stable, relapsing-remitting multiple sclerosis (RRMS)…

A statistical model that takes clinical and demographic factors into account could help guide treatment decisions in people with relapsing-remitting multiple sclerosis (RRMS) who haven’t yet started on a multiple sclerosis (MS) therapy, a study reports. “Our study offers a predictive tool that fulfills an unmet need for…

Using Ocrevus (ocrelizumab) as a first-line treatment for early-stage relapsing forms of multiple sclerosis (MS) is significantly better at delaying disease progression than starting with a less effective drug and switching to Ocrevus later. That’s according to nine years of data from the OPERA I (NCT01247324) and…

Relapsing-remitting multiple sclerosis (RRMS) patients with low educational attainment are more likely to delay the start of disease-modifying therapies (DMTs) after a diagnosis than those with a high educational status, a Danish study suggests. Educational status wasn’t significantly associated with diagnostic delays after the onset of symptoms,…

Navigating the uncertainty of living with relapsing-remitting multiple sclerosis (RRMS) brings a number of challenges, a study shows. That uncertainty is best described as the intangible, difficult to define space between hope — the sense that things might get better or at least not turn out so badly —…

Nearly all adults with relapsing forms of multiple sclerosis (MS) said they are highly satisfied with the Sensoready autoinjector pen to self-administer Kesimpta (ofatumumab), according to a recent U.S. survey. High satisfaction was mainly driven by the reasonable administration time and ease of use, the researchers said. The…

A Phase 2 clinical trial is currently recruiting adults with relapsing types of multiple sclerosis (MS) to investigate Zenas Biopharma’s experimental therapy obexelimab as a weekly subcutaneous, or under-the-skin, injection, the company has announced in a press release. The study, called MoonStone (NCT06564311), is open to…

A three-month course of acupuncture was associated with gains in certain aspects of cognition for people with relapsing-remitting multiple sclerosis (RRMS) in a small clinical trial. The traditional Chinese medicine was also linked to less fatigue, improved sleep, and reductions in certain psychological problems such as depression. The findings…

Stem cell transplant can be considered a viable treatment option for people with relapsing-remitting multiple sclerosis (MS) who are young, early in the disease course, do not have other major health issues, and have failed to respond to available medications, according to a new set of recommendations. The procedure…

TG Therapeutics is working to develop a subcutaneous, or under-the-skin, version of Briumvi (ublituximab-xiiy), its approved therapy for relapsing forms of multiple sclerosis (MS). The company said it plans to start a pivotal clinical program this year which could support an application seeking approval of the…

The beginning of the new year is an opportunity for a fresh start, change, and personal growth. Even before I was diagnosed with relapsing-remitting multiple sclerosis, I struggled deeply to allow myself moments of rest and peace, and that continues today. I’m aware of those struggles, but until now…

Cabaletta Bio is getting set to launch a clinical trial testing its cell therapy resecabtagene autoleucel (rese-cel) in people with relapsing and progressive forms of multiple sclerosis (MS). The company sought permission last year from the U.S. Food and Drug Administration (FDA) to start the study. Once such…

Patient enrollment has been completed ahead of schedule in a Phase 2 clinical trial evaluating Contineum Therapeutics‘ PIPE-307, an oral therapy aiming to restore myelin — a process known as remyelination — in people with relapsing-remitting multiple sclerosis (RRMS), the company announced. The VISTA trial (NCT06083753), launched…

Immunic Therapeutics says it remains “on track” in testing its multiple sclerosis treatment candidate vidofludimus calcium in twin Phase 3 clinical trials with people who have relapsing disease — and in the Phase 2 CALLIPER study involving those with progressive forms of MS. Indeed, in a new company…

Men with multiple sclerosis (MS) who started on high-efficacy disease-modifying therapies (DMTs) experienced significantly fewer relapses than those who started with moderate-efficacy DMTs, according to real-world claims analysis involving more than 10,000 U.S. patients. “No significant difference in relapse was found among females,” researchers wrote. “This observation highlights…

Being born and raised in south-central Texas, I’m no stranger to the heat here that dominates most of the year. But even after 25 years of living in Texas, I don’t think I’m used to it. While some people embrace and enjoy warmer weather, my body rejects it altogether, especially…

I was diagnosed with relapsing-remitting multiple sclerosis at 17 years old, during my senior year of high school. At that time, the diagnosis was the least of my worries because my top priorities were senior year activities and college preparation. The truth, however, was that I didn’t comprehend what…

A large majority of people with relapsing-remitting multiple sclerosis (RRMS) who received Tysabri (natalizumab) in a real-world setting experienced no evidence of disease activity for as long as six years, according to a study from a single center in Hungary. No evidence of disease activity, known as NEDA-3,…