February 23, 2024 News by Margarida Maia, PhD Most MS patients stay relapse-free 6 years after stem cell transplant About 4 in 5 people with relapsing-remitting multiple sclerosis (RRMS) who receive a stem cell transplant remain free of relapses for at least six years, and this may translate into being able to get back to work, a small study from Norway suggests. The study, āAutologous hematopoietic…
December 23, 2022 News by Steve Bryson, PhD Stem Cell Transplant More Effective for SPMS Than Medications: Study A stem cell transplant more effectively slowed disability worsening in people with active secondary progressive multiple sclerosis (SPMS) than anti-inflammatory treatments and disease-modifying therapies (DMTs), a study has found. More transplant recipients also experienced clinical improvements that were sustained after three and five years. After 10 years,…
November 16, 2022 News by Marisa Wexler, MS How Stem Cell Transplant Can āResetā Immune System in MS: Study Following an autologous hematopoietic stem cell transplant (aHSCT) in people with multiple sclerosis (MS), the population of ānaĆÆveā T-cells ā components of the immune system that enable the body to fight off new, unrecognized infections ā is completely renewed but some memory T-cells, which are responsible for rapid responses…
October 4, 2022 News by Marisa Wexler, MS Stem Cell Transplant May Halt Nerve Fiber Damage in RRMS: Study Autologous hematopoietic stem cell transplant (aHSCT) reduces markers of nerve fiber and myelin damage in people with relapsing-remitting MS (RRMS), according to a small study done in Sweden. “We investigated if therapeutic intervention with aHSCT could halt the injurious process leading to tissue damage in MS,” researchers wrote.
August 31, 2022 News by Lindsey Shapiro, PhD Stem Cell Transplant in MS: Patients Support, but Neurologists Hesitant People who underwent a hematopoietic stem cell transplant (HSCT), many of them patients with multiple sclerosis (MS), were supportive of the treatment despite its high costs ā and hesitancy and opposition from their neurologists ā a survey study showed. Most surveyed HSCT recipients ā about 85% ā believed…
February 25, 2022 News by Marisa Wexler, MS #ACTRIMS2022 ā Immune System ‘Reset’ by Stem Cell Transplant Undergoing a stem cell transplant, a procedure that aims to “reset” a person’s immune system, can reduce relapse rates and ease disability in people with multiple sclerosis (MS), new data show. The findings suggest that such a transplant ā fully, autologous hematopoietic stem cell transplantation or aHSCT ā is…
October 21, 2021 News by Marta Figueiredo, PhD National MS Society Supports Stem Cell Transplant for Select, Aggressive RRMS The National Multiple Sclerosis Society supports the use of a patient-derived bone marrow transplant to treat people with very aggressive relapsing-remitting multiple sclerosis (RRMS) who responded poorly to disease-modifying therapies (DMTs). This position is in line with a recent set of society recommendationsĀ on how and in…
October 15, 2021 News by Marta Figueiredo, PhD #ECTRIMS2021 ā Stem Cell Transplant May Better Treat SPMS Than DMTs Editorās note: TheĀ Multiple Sclerosis News Today team is providing in-depth coverage of the virtual 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Oct. 13ā15. GoĀ here to see the latest stories from the conference.
June 11, 2021 News by Patricia Inacio, PhD Stem Cell Transplant Trial Enrolls First Patient in Minnesota A clinical trial investigating patient-derived stem cell transplants for the treatment of people with severe relapsing forms of multiple sclerosis (MS) has enrolled a patient in Minnesota. The patient was enrolled at the University of Minnesota Medical School, one of two trial sitesĀ in the state. An additional 18…
December 10, 2020 News by Diana Campelo Delgado Stem Cell Transplant Reduces Relapses and Disability in RRMS, Study Suggests Autologous hematopoietic stem cell transplant (AHSCT) induces a reduction in relapse rate and physical disability in patients with relapsing-remitting multiple sclerosis (RRMS) who respond inadequately to other treatments, a small study suggests. The study, āSelective cognitive dysfunction and physical disability improvement after autologous hematopoietic stem cell transplantation…
November 10, 2020 News by Marta Figueiredo, PhD Stem Cell Transplant More Effective Than Lemtrada in Treating RRMS, Study Suggests An autologous hematopoietic stem cell transplantĀ (AHSCT) is more effective than LemtradaĀ (alemtuzumab) at achieving no evidence of disease activity and preventing relapses in people with relapsing-remitting multiple sclerosisĀ (RRMS), a real-life study in Sweden reported. Adverse events (side effects) were more frequent with AHSCT over the first three…
January 16, 2020 News by Ana Pena PhD Magenta Therapeutics to Advance Safer Immune Reset Therapy for MS Stem Cell Transplant in 2020 Magenta Therapeutics will continue to advance its investigational conditioning therapyĀ CD45-ADC for patients with autoimmune diseases undergoing stem cell transplants, the company highlighted in a progress report. CD45-ADC is a therapy designed to remove disease-causing immune cells in a safer way when preparing patients for a stem…
September 16, 2019 Columns by Ed Tobias MS News that Caught My Eye Last Week: Stem Cell Transplants, Remyelination Agent, Tecfidera Study, Plasma Exchange and Tysabri-linked PML It’s been a big week for interesting stories, as the annual meeting of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) has just concluded. The conference offered much to engage healthcare professionals and researchers, but the following are some presentations that appealed to me as a multiple…
August 20, 2019 News by Ana Pena PhD Exploring Early Treatment Strategies for RRMS: An Interview with Neurologist Daniel Ontaneda When it comes to initial treatment selection for relapsing-remitting multiple sclerosis (RRMS), there is one question that has yet to be answered: Is it better to start with potentially safer moderately effective disease-modifying treatments (DMTs) or to hit the disease immediately with a high-efficacy DMT that may be…
September 12, 2017 News by Patricia Silva, PhD Swedish Study Suggests Stem Cell Transplants as Possible Treatment for Aggressive RRMS Autologous hematopoietic stem cell transplants for relapsing-remitting multiple sclerosis (RRMS) are superior to currently approved disease-modifying drugs,Ā according to a Swedish studyĀ published in the Journal of Neurology, Neurosurgery & Psychiatry. In addition, says the review, the procedure’s safety profile has improved in the last decade, and is now just…
August 15, 2016 News by Patricia Silva, PhD New Pre-HSCT Treatment May Make Stem Cell Transplants a Safer Option for MS Patients Scientists at Stanford University School of Medicine have developed a method for stem cell transplants that may doĀ away with the need for prior systematic treatment with chemotherapy or radiotherapy. If successful, stem cell transplants could be an option for patients with multiple sclerosis (MS), an option nowĀ limited by the…
June 6, 2016 Columns by admin Stem Cell Transplants – an Exciting MS Therapy Development Stem cell treatment of MS, whichĀ came under the spotlight at last weekās 16th Annual Meeting of the Consortium of Multiple Sclerosis Centers (CMSC) when Dr. Mark Freedman discussed the procedure, is an exciting area within the development of therapies. Dr. Freedman, professor of medicine (neurology) at the…
January 2, 2015 News by Charles Moore Three Years After Stem Cell Transplant Therapy Most MS Patient Subjects Still In Remission A new study published online before print in the journal JAMA Neurology reports that three years on, most members of a small subject group of patients with active relapsing-remitting (RR) multiple sclerosis (MS) who had received an experimental high-dose immunosuppressive therapy (HDIT) followed by a transplant of their own…
August 8, 2014 News by Patricia Silva, PhD NUC Reports Promising Results of Stem Cell Transplants in MS Patients A new stem cell transplantĀ therapy may offer patients with multiple sclerosis (MS) an alternative treatment option. According to a recent report on KCBDĀ by Kasie Davis, researchers are pointing to the success of an MS patient namedĀ Dan Tiel, who had been reduced to living in a wheelchair due to…