Phase 3 Tolebrutinib Trials Pause US Enrollment Over Safety Concerns
The U.S. Food and Drug Administration (FDA) has placed a partial clinical hold on Phase 3 trials testing the investigational…
Articles by Lindsey Shapiro, PhD
UK Study: Fatigue Often Influences Quality of Life in MS
Fatigue is a common symptom among people living with multiple sclerosis (MS), and has a significant negative impact on…
Nabiximols Fails to Meet Trial Goal of Easing Leg Spasticity
The Phase 3 RELEASE MSS1 clinical trial testing nabiximols oral spray failed to meet its primary goal of easing…
OM1 Develops Algorithm to Estimate EDSS Scores
OM1 has created an artificial intelligence (AI)-based algorithm to estimate scores on the expanded disability status scale (EDSS),…
Ublituximab’s Therapeutic Benefit Revealed in ULTIMATE Trials Analyses
Ublituximab, an investigational antibody-based treatment for multiple sclerosis (MS), was efficacious across most patient subgroups, and led to marked…
Alcohol Use, Cholesterol Tied to Liver Injury With Pulse Steroid Therapy
A short course of high-dose methylprednisolone was associated with signs of mild liver injury in nearly 3% of multiple…
aHSCT, Stem Cell Therapy for RRMS, Troubled by Unknowns, Paper Says
Autologous hematopoietic stem cell transplant (aHSCT) has shown some promise as a treatment option for highly active relapsing-remitting…
Erectile Dysfunction Can Affect Most Men With MS, Analysis Suggests
The risk of erectile dysfunction was about three times greater in men with multiple sclerosis (MS) compared with healthy…
MS Bike, Canadian Society’s Annual Fundraiser, Returns to Live Rides
The Multiple Sclerosis Society of Canada has opened MS Bike, an annual cycling event to raise awareness and funds for…
Beer Consumption May Be Linked to MS Risk: Meta-analysis
Alcohol intake is not significantly associated with an increased risk of developing multiple sclerosis (MS), but specifically drinking beer…
Bioasis Purchases EGF Therapy Platform for MS, Other Diseases
Cresence AS has sold its epidermal growth factor (EGF) platform comprising investigational therapies for multiple sclerosis (MS)…
Ekso’s Wearable Exoskeleton Cleared by FDA for Walking Rehab Use
The U.S. Food and Drug Administration has given Ekso Bionics clearance to market its wearable robotic exoskeleton to aid…
Evusheld Boosts Antibodies Against COVID-19 in Vaccinated Patients
Treatment with Evusheld (tixagevimab co-packaged with cilgavimab) after COVID-19 vaccination significantly boosted the levels of antibodies against the virus…
Blocking Kidney Protein Prevents Progression in MS Mouse Model
A protein called nephronectin mediates autoimmunity in a mouse model of multiple sclerosis (MS), and blocking this protein was…
Blood Test to Monitor MS Activity Supports Optimal Care, Octave Says
A blood biomarker test developed by Octave can effectively monitor overall disease activity in people with multiple sclerosis…
Fibroblast Cell Therapy Shows Early Promise in MS Patients
A single infusion of FibroBiologics‘ investigational cell therapy, CYMS101, was able to inhibit disease activity in a mouse…
$3.9M Grant Awarded to Study Effects of Low-glycemic Diet
The U.S. Department of Defense (DOD) has awarded $3.9 million to fund clinical research to test the impact of a…
Fecal Transplants Show Safety, Potential to Enrich Gut in Small Trial
Repeated fecal transplants from healthy donors were safe and well-tolerated in a small group of people with relapsing-remitting multiple…
Exergaming Shows ‘Superior’ Efficacy at Easing MS Symptoms in Trial
A five-week, high-intensity video game-based exercise program called exergaming outperformed other forms of exercise at easing symptoms and improving life…
Consistency in DMT Use ‘Low’ in US, Influenced by Side Effects, Insurance
Persistent use of a single disease-modifying therapy (DMT) over a three-year period was low among people with relapsing forms…
Genetic Indicators of High BMI in Childhood Linked to Higher MS Risk
Genetic variants that contribute to a high body mass index (BMI) during childhood are associated with an increased risk of developing…
Low-impact Aquatic Exercise a Good Alternative, but Access Is a Barrier
Aquatic exercise is used less often by people with multiple sclerosis (MS) than land-based exercise, but it’s generally well…
Gilenya, Tysabri Show Superiority at Preventing Relapses in Children
Gilenya (fingolimod) and Tysabri (natalizumab) were more effective at lowering relapse rates in children with multiple sclerosis…
NervGen Cleared to Enroll Final Group in Trial of NVG-291
NervGen Pharma has received approval to enroll a third and final group of healthy volunteers in the multiple ascending…
Disease Severity, Brain Changes Linked to Cognitive Decline
Disease severity, brain volume loss, and brain lesions are able to predict later cognitive declines in people with relapsing-remitting…
Phase 3 Trial to Assess Benefits of Group Resilience Training Program
A Phase 3 trial will test the ability of a group resilience training program, called READY, to promote quality of…
MS May Influence Timely Cancer Screenings, Diagnosis: Study
Breast cancer is less likely to be detected through a routine cancer screening for women with multiple sclerosis (MS), while…
Prevalence of MS Among Black People ‘Under-recognized’: Study
Rates of multiple sclerosis (MS) were similar among Black and white people, but significantly lower in Hispanics and Asians…
Maresin-1 Molecule Eases Inflammation, Symptoms in Mouse Model
Administering the maresin-1 molecule — a natural anti-inflammatory in the body — in a mouse model of multiple sclerosis…
PoNS Device for MS-associated Gait Problems Now Available in US
The portable neuromodulation stimulator (PoNS) device, which improves walking abilities in people with multiple sclerosis (MS), is now…