Fatigue is a significant predictor of worse health-related quality of life in adults with relapsing-remitting multiple sclerosis (RRMS), a study reports. High levels of fatigue were significantly linked with worse physical and mental health, including cognitive impairments, depression, and anxiety. The findings suggest…

People with relapsing-remitting multiple sclerosis (RRMS) have elevated levels of the lipocalin 2 (Lcn-2) protein in their stool samples, a marker for intestinal inflammation, compared with healthy controls, a study demonstrated. Among patients, findings also demonstrated those with high fecal Lcn-2 had changes in their gut microbiome, the collection…

Initial treatment with Novantrone (mitoxantrone) can reduce the risk of relapses and worsening disability in people with highly active relapsing-remitting multiple sclerosis (RRMS), according to a 10-year study from France. “Our results support the short-term use of [Novantrone], followed by a maintenance therapy for patients with early highly…

Note: This story was updated Jan. 12, 2022, to note that Ponvory is approved in the U.K. for people with relapsing forms of MS who have active disease, defined by clinical or imaging features. The National Institute for Health and Care Excellence (NICE) has recommended that Ponvory (ponesimod)…

A model that considers changes in brain volume and serum neurofilament (sNfL) levels during the early stages of multiple sclerosis may help clinicians to determine an individual’s likely progression with relapsing forms of MS, a study suggests. “We were able to build reliable, robust models capable of accurate predictions of…

What do a broken-down, out-of-tune piano and multiple sclerosis have in common? Well, they’re both disorderly and confusing, to say the least. But there’s something else — they have the potential to bring about something positive. I learned this from a podcast called “Hidden Brain,” specifically from an…

Grey matter atrophy — its loss —  follows a sequential pattern that expands to involve more regions of the brain over time in all multiple sclerosis (MS) patients, regardless of their disease type, a new study reports. Atrophy progression is also similar between relapsing-remitting multiple sclerosis (RRMS) and primary-progressive multiple sclerosis (PPMS)…