News

Fatigue is a common symptom among people living with multiple sclerosis (MS), and has a significant negative impact on physical and psychological function, as well as quality of life, a U.K. study reported. Citing the study as the “largest study on fatigue in MS from U.K.,”  researchers emphasized that…

Long-term treatment with Zeposia (ozanimod) stabilizes or even improves cognitive function in adults with relapsing forms of multiple sclerosis (MS), particularly among those with greater brain volumes. That’s according to five years of data from the completed SUNBEAM Phase 3 clinical trial (NCT02294058) and the ongoing…

The Phase 3 RELEASE MSS1 clinical trial testing nabiximols oral spray failed to meet its primary goal of easing leg spasticity in patients with multiple sclerosis (MS), according to Jazz Pharmaceuticals, the company currently developing the nabiximols clinical program. Enrolling 68 MS patients,…

OM1 has created an artificial intelligence (AI)-based algorithm to estimate scores on the expanded disability status scale (EDSS), an established method for evaluating disability and disease progression in people with multiple sclerosis (MS). The algorithm, using a method called machine learning, was trained to estimate EDSS scores…

Ublituximab, an investigational antibody-based treatment for multiple sclerosis (MS), was efficacious across most patient subgroups, and led to marked improvements in disability and quality of life over nearly two years. This is according to new exploratory analyses from the identical Phase 3 ULTIMATE I and II trials, which evaluated…

People with relapsing forms of multiple sclerosis (MS) who were continuously on Kesimpta (ofatumumab) for up to four years were about four times more likely to have no evidence of disease activity than those initially on Aubagio (teriflunomide), according to updated data from the ASCLEPIOS and ALITHIOS…

A short course of high-dose methylprednisolone was associated with signs of mild liver injury in nearly 3% of multiple sclerosis patients given this treatment, according to a study in Iran. Notably, a history of alcohol abuse and hyperlipidemia — higher-than-normal blood levels of fatty molecules such as cholesterol — were…

Proteins called tenascins block the regeneration of myelin by modulating the activity of oligodendrocytes, myelin-making cells of the central nervous system, a study in mouse models indicates. “Our research results open up new therapeutic approaches for the treatment of demyelinating diseases such as multiple sclerosis,” Juliane Bauch, a researcher at Ruhr-University…

Black Americans with multiple sclerosis (MS) have a higher chance of having uncontrolled high blood pressure (hypertension), despite being more likely to receive anti-hypertensive medication than white patients, a large study found. Further studies are needed to confirm these findings and…

The National Institute for Health and Care Excellence (NICE) in England has updated its guidelines for the diagnosis and management of adults with multiple sclerosis (MS). Called Multiple sclerosis in adults: management, the new guidelines update and replace the 2014 recommendations and are meant to be followed by…

Biogen has secured a new patent in Europe covering the use of its oral therapy Tecfidera (dimethyl fumarate) for multiple sclerosis (MS) through 2028, the company announced. Granted by the European Patent Office, patent EP2653873 covers the composition and use of dimethyl fumarate at a dose of 480…

Autologous hematopoietic stem cell transplant (aHSCT) has shown some promise as a treatment option for highly active relapsing-remitting multiple sclerosis (RRMS), but more clinical evidence is needed to support its use, a team of researchers in the U.K. suggest. “Uncertainty remains as to how aHSCT compares with current…

The risk of erectile dysfunction was about three times greater in men with multiple sclerosis (MS) compared with healthy men, according to a recent meta-analysis of published studies. It was identified in nearly half of the 2,760 adult male patients in these studies, highlighting the importance of diagnosing…

The Multiple Sclerosis Society of Canada has opened MS Bike, an annual cycling event to raise awareness and funds for research and services that make the difference for the more than 90,000 Canadians living with multiple sclerosis (MS). Conducted in an entirely virtual format due to COVID-19 in 2020…

Alcohol intake is not significantly associated with an increased risk of developing multiple sclerosis (MS), but specifically drinking beer may elevate the risk, according to a recent meta-analysis. The association, however, was limited by a small number of included studies. “Further large-scale prospective studies should be conducted to verify…

Unusual growth in an immune cell class called myeloid cells is evident in the bone marrow of people with multiple sclerosis (MS), and these cells likely contribute to the inflammation that drives the disease, according to a new study. Experiments in mice suggest that myelin-reactive T-cells can migrate to the bone…

Cionic‘s leg-worn Neural Sleeve, recently authorized in the U.S. to aid walking in people with multiple sclerosis (MS) and other conditions that impair mobility, reduced foot drop in a small clinical trial. Patients in the trial also reported marked reductions in pain and mental health problems, according to…

Cresence AS has sold its epidermal growth factor (EGF) platform comprising investigational therapies for multiple sclerosis (MS) and other neurodegenerative diseases to Bioasis Technologies. Under the terms of the agreement, Bioasis will own all intellectual property related to the EGF platform. In exchange, it will issue…

Treatment with the experimental immune-modulating therapy vidofludimus calcium reduced disease activity on MRI scans in adults with relapsing-remitting multiple sclerosis (RRMS), data from the Phase 2 EMPhASIS clinical trial shows. Top-line results from EMPhASIS were reported by the therapy’s developer Immunic Therapeutics in 2020. Researchers at…

Innovative Trials has selected the MS Society UK as its charity partner for the next year, and intends to raise at least £3,000 (about $3,600) to support multiple sclerosis (MS) research and the society’s quest for a world without MS. Innovative Trials works with pharmaceutical companies and…

A new tool called signal detection theory (SDT) found a relationship between subjective cognitive fatigue, often experienced by people with multiple sclerosis (MS), and the activation of certain brain regions, a study reported. Although the relationship was found in both patients and healthy controls after cognitive fatigue was…

Treatment with foralumab nasal spray resulted in marked clinical improvements after three months in the second secondary progressive multiple sclerosis (SPMS) patient treated under a single-patient access program. The findings were generally consistent with those seen in the first SPMS patient and supported a decision by the U.S. Food…

The U.S. Food and Drug Administration has given Ekso Bionics clearance to market its wearable robotic exoskeleton to aid in rehabilitation programs to improve gait and mobility in people with multiple sclerosis (MS). Dubbed EksoNR, the device had been approved by the regulatory agency for stroke and spinal…

Higher numbers of immune cells circulating in the bloodstream may mean a greater likelihood of developing multiple sclerosis (MS), according to a study based on a large pool of genetic data in people of European ancestry. One particular type of immune cell, called natural killer (NK) cells, was linked…

Dysport (abobotulinumtoxinA), a form of purified botulinum toxin, has received a positive opinion in Europe for managing urinary incontinence in adults with neurogenic detrusor overactivity (NDO), or overactive bladder. The opinion is specifically for those who experience bladder issues due to multiple sclerosis (MS) or spinal cord…

Find Therapeutics and SATT Conectus have joined forces to develop a promising therapy for multiple sclerosis (MS) and optic neuritis based on a new class of compounds that shows the potential to regenerate myelin. Myelin is the fatty protective sheath around nerve fibers that’s progressively lost…

The overall risk of death is about 75% higher for people with multiple sclerosis (MS) than in the general population, according to a new study. “The association was independent of demographic, socioeconomic variables, lifestyle factors, baseline diabetes, cardiovascular disease, chronic respiratory disease, and cancer status,” researchers wrote. The study,…

Erin Stevenson’s doctor laughed when she asked him 13 years ago if the vertigo she felt while training for a first 100-mile bike ride could be related to her mother’s multiple sclerosis (MS). MS isn’t a genetic disease, but Stevenson managed to persuade the doctor to schedule a brain…

Treatment with Evusheld (tixagevimab co-packaged with cilgavimab) after COVID-19 vaccination significantly boosted the levels of antibodies against the virus among people with multiple sclerosis (MS) who were taking B-cell targeted therapies, a small study showed. “This is important as it provides a different strategy for protection against…

Treatment with the approved multiple sclerosis (MS) therapy dimethyl fumarate (DMF) did not affect the function of the thyroid gland, an organ that secretes hormones to regulate metabolism, a medical records study concluded. Screening for thyroid problems is not needed for people with MS considered for DMF therapy, the…