Cognitive behavioral therapy, a type of “talk” therapy, may help ease the severity of insomnia, fatigue, and anxiety in people with multiple sclerosis (MS), improving the quality of their sleep, data from a single-site trial suggest. The study “Feasibility and Treatment Effect of Cognitive Behavioral Therapy for Insomnia…

Insomnia, and all that repeat sleepless nights mean, burden a vast majority — 85% — of people with multiple sclerosis (MS), a survey of patients who are part of the Shift.MS social network in the U.K. reports. The online community of more than 30,000 people examines this symptom in…

It is 2 a.m. and I am awake. I sit on the couch with my head in my hands. The leg pain that broke my slumber is now extreme. I have taken my medications, used my topical, and applied heat. All to no avail. Exhaustion meets pain as my eyes…

I do not sleep well. Ever. I have tried a myriad of meditations and medications, yet sleep evades me. It is 2:30 a.m. and infomercials are taking over the airwaves. My knowledge of everything Ginsu knives is overrated. (Pro tip: If you wait until the end they always offer…

Non-pharmacological interventions such as mindfulness and exercise may improve sleep for people with multiple sclerosis (MS) while boosting overall psychological well-being and quality of life, according to a meta-analysis of several studies. While the studies were very different from each other, making it difficult to draw reliable conclusions, the…

Treatment with modafinil, a medication used to reduce excessive sleepiness, and cognitive behavioral therapy (CBT) can both provide clinically meaningful reductions in fatigue in people with multiple sclerosis (MS), a new study reports. Combining modafinil with CBT, a form of talk therapy, wasn’t more effective for MS-related fatigue than…

Most people take for granted the feeling of stability while standing on their feet. My invisible multiple sclerosis (MS) symptom is unsteady gait, one of my biggest struggles, but you likely wouldn’t know it just by looking at me. My unsteady gait is associated with the effect that…

Treatment with modafinil, a stimulant approved in the U.S. for treating certain sleep-related disorders, significantly reduced fatigue and improved overall quality of life when used in clinical trials for people with multiple sclerosis (MS), according to a review of published study data. However, its use was linked to a…

Note: This column describes the author’s own experiences with sleep medications and antidepressants. Not everyone will have the same response to treatment. Consult your doctor before starting or stopping a therapy. Many years ago, it was brought to my attention that I suffer from insomnia and chronic fatigue.

Note: This column describes the author’s own experiences with high-dose steroids to treat multiple sclerosis (MS). Not everyone will have the same response to treatment. Consult your doctor before starting or stopping a therapy. My first experience treating an MS relapse with intravenous steroids was interesting.

Day 29 of 31 This is Mike and Jenn Powell’s story, as a conversation: Jenn and Mike Powell stand with their dog, Skye, in Laguna Beach in November 2023. (Photo by Vicki Shequin) Jenn Powell: My husband, Mike, hates multiple sclerosis (MS). There was a…

The most common real-world side effects linked to dalfampridine — sold as Ampyra and with generics available — are similar to those listed on its prescribing label for multiple sclerosis (MS), according to data from a safety surveillance database. Common side effects included urinary tract infection (UTI), dizziness…

One year of treatment with Lemtrada (alemtuzumab) significantly improved cognitive abilities, particularly with processing speed, and eased depression in people with relapsing forms of multiple sclerosis (MS), a small real-world study reported. Most of the 39 patients (92%) evaluated after that treatment year showed either stable or improved…

An arm of the European Medicines Agency favors the approval of Briumvi (ublituximab) to treat adults with active, relapsing forms of multiple sclerosis (MS) across the European Union (EU). The Committee for Medicinal Products for Human Use (CHMP) opinion is based on data from twin Phase 3 trials,…

Note: This story was updated March 29, 2023, to correct that cognitive function was assessed via questions about memory and three other cognition outcomes. Sleep disorders such as insomnia, sleep apnea, and sleepiness may contribute to self-reported cognitive decline in women with multiple sclerosis (MS), a new study suggests.

Photo courtesy of Cassidy V. Chapman Day 10 of 31 This is Cassidy V. Chapman’s story: I was diagnosed with relapsing-remitting multiple sclerosis in January 2004 at the age of 22, the day before my 23rd birthday. It happened during my first year of law school. Still,…

Want to reduce your multiple sclerosis (MS) fatigue? Maybe we should talk about it. I’m talking about a fatigue treatment called cognitive behavioral therapy (CBT), which usually involves changing a person’s thinking and behavior. By talking with a therapist, sometimes on the phone, a patient develops an…

The new year is bringing a new disease-modifying therapy (DMT) to the multiple sclerosis (MS) arsenal. Shortly after Christmas, the U.S. Food and Drug Administration (FDA) approved Briumvi (ublituximab), which joins a small group of DMTs that aim to halt MS progression by knocking out certain…

The U.S. Food and Drug Administration has approved TG Therapeutics‘ B-cell-depleting therapy ublituximab under the brand name Briumvi for the treatment of adults with relapsing forms of multiple sclerosis (MS), the company announced. The approval covers clinically isolated syndrome, relapsing-remitting MS (RRMS), and active secondary progressive…

Multiple sclerosis (MS) and a good night’s sleep seem to be mutually exclusive. I seriously doubt that anyone with MS will reply in the comments that the disease has blessed them with the best sleep of their lives. Yet I used the word “seem” because when writing about any…

In this installment of our “Expert Voices” series, Multiple Sclerosis News Today asked Alexa Kane to answer some of your questions about how sleep affects multiple sclerosis (MS) and vice versa. Kane is a clinical health psychologist at the Cleveland Clinic Mellen Center for Multiple Sclerosis for Treatment and…

Some prodromal symptoms of multiple sclerosis (MS) — symptoms that are evident before the disease begins in earnest — could help to predict the course of MS, a new study proposes. In particular, its researchers suggest that MS patients with prodromal depression are more likely to be diagnosed…

Worsening disability was associated with worry about COVID-19 in people with multiple sclerosis (MS) living in the U.S. and Italy, a study evaluating the pandemic’s impact has found. In both countries, MS patients with greater psychological disabilities, such as depression, were more likely to have worrying thoughts, while those…

Multiple sclerosis (MS) patients with fatigue have significantly lower levels of amyloid precursor protein (APP) — a molecule involved in nerve cell function — in the cerebrospinal fluid (CSF) relative both to those without this common symptom and healthy people, a study shows. The CSF is the liquid…

“I close my eyes/ Only for a moment then the moment’s gone/ All my dreams pass before my eyes, a curiosity.” — Kansas, “Dust in the Wind”  The dark cloud of fatigue first swept through my mind toward the end of 2018. I was no stranger to physical fatigue,…

“Hey, man, I’m alive. I’m taking each day and night at a time/ I’m feeling like a Monday but someday I’ll be Saturday night.” — Bon Jovi Multiple sclerosis (MS) medications can generally be separated into two categories: disease-modifying therapies (DMTs) and those that help to manage symptoms. While…

In this installment of our “Expert Voices” series, Multiple Sclerosis News Today asked Allen C. Bowling, MD, PhD, to answer some of your questions related to complementary and alternative medicine (CAM) for people with multiple sclerosis (MS). Bowling is an internationally recognized neurologist and integrative medicine pioneer with…

Cognition-targeting exercise, when combined with cognitive behavioral therapy (CBT) — a type of talk therapy — may further ease fatigue and other symptoms in people with multiple sclerosis (MS), a study found. The study, “The added value of cognition-targeted exercise versus symptom-targeted exercise for multiple sclerosis fatigue: A randomized…

Taking the hormone melatonin may increase overall sleep quality in people with multiple sclerosis (MS), a clinical trial found. The compound, available as an over-the-counter dietary supplement, was particularly effective at extending sleep time in patients. Of note, sleep time decreased with age, meaning that “younger participants may have…